Neural correlates of the attention network test in schizophrenia.
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| Title: | Neural correlates of the attention network test in schizophrenia. |
|---|---|
| Authors: | Backes, Volker, Kellermann, Thilo, Voss, Bianca, Krämer, Jörn, Depner, Conny, Schneider, Frank, Habel, Ute |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Nov2011, Vol. 261, p155-160. 6p. |
| Subjects: | Attention, Schizophrenia, Cognitive ability, Neurology, Orienting reflex, Magnetic resonance imaging, Behavior disorders |
| Abstract: | Attentional deficits are prominent in schizophrenia, affecting nearly all cognitive functions. Human attention comprises three essential components: alerting, orienting and executive control. For the assessment of these functions, the attention network test (ANT) has been proposed and used in healthy controls and patients. In schizophrenia, the ANT has revealed behavioral deficits; however, the corresponding neural correlates have not been examined. In the present study, neural correlates of attention were investigated in 17 schizophrenia patients and 17 healthy controls using the ANT with fMRI. Behavioral deficits emerged in the alertness system with a reduced efficiency for temporal cues. In fMRI, changes were observed for all three domains-alerting, orienting and conflict-and revealed hyper- as well as hypoactivation in patients. Affected regions during alerting comprised a broad fronto-temporo-parieto-occipito-cerebellar network, while differences during orienting mainly tapped fronto-parietal regions and during conflict processing a thalamo-frontal-temporal occipital network including the postcentral regions. In general, hyperactivations were positively correlated with more severe psychopathologial symptoms. [ABSTRACT FROM AUTHOR] |
| Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 66951848 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Neural correlates of the attention network test in schizophrenia. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Backes%2C+Volker%22">Backes, Volker</searchLink><br /><searchLink fieldCode="AR" term="%22Kellermann%2C+Thilo%22">Kellermann, Thilo</searchLink><br /><searchLink fieldCode="AR" term="%22Voss%2C+Bianca%22">Voss, Bianca</searchLink><br /><searchLink fieldCode="AR" term="%22Krämer%2C+Jörn%22">Krämer, Jörn</searchLink><br /><searchLink fieldCode="AR" term="%22Depner%2C+Conny%22">Depner, Conny</searchLink><br /><searchLink fieldCode="AR" term="%22Schneider%2C+Frank%22">Schneider, Frank</searchLink><br /><searchLink fieldCode="AR" term="%22Habel%2C+Ute%22">Habel, Ute</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Nov2011, Vol. 261, p155-160. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Attention%22">Attention</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+ability%22">Cognitive ability</searchLink><br /><searchLink fieldCode="DE" term="%22Neurology%22">Neurology</searchLink><br /><searchLink fieldCode="DE" term="%22Orienting+reflex%22">Orienting reflex</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Behavior+disorders%22">Behavior disorders</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Attentional deficits are prominent in schizophrenia, affecting nearly all cognitive functions. Human attention comprises three essential components: alerting, orienting and executive control. For the assessment of these functions, the attention network test (ANT) has been proposed and used in healthy controls and patients. In schizophrenia, the ANT has revealed behavioral deficits; however, the corresponding neural correlates have not been examined. In the present study, neural correlates of attention were investigated in 17 schizophrenia patients and 17 healthy controls using the ANT with fMRI. Behavioral deficits emerged in the alertness system with a reduced efficiency for temporal cues. In fMRI, changes were observed for all three domains-alerting, orienting and conflict-and revealed hyper- as well as hypoactivation in patients. Affected regions during alerting comprised a broad fronto-temporo-parieto-occipito-cerebellar network, while differences during orienting mainly tapped fronto-parietal regions and during conflict processing a thalamo-frontal-temporal occipital network including the postcentral regions. In general, hyperactivations were positively correlated with more severe psychopathologial symptoms. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00406-011-0264-9 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 155 Subjects: – SubjectFull: Attention Type: general – SubjectFull: Schizophrenia Type: general – SubjectFull: Cognitive ability Type: general – SubjectFull: Neurology Type: general – SubjectFull: Orienting reflex Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Behavior disorders Type: general Titles: – TitleFull: Neural correlates of the attention network test in schizophrenia. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Backes, Volker – PersonEntity: Name: NameFull: Kellermann, Thilo – PersonEntity: Name: NameFull: Voss, Bianca – PersonEntity: Name: NameFull: Krämer, Jörn – PersonEntity: Name: NameFull: Depner, Conny – PersonEntity: Name: NameFull: Schneider, Frank – PersonEntity: Name: NameFull: Habel, Ute IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 10 Text: Nov2011 Type: published Y: 2011 Identifiers: – Type: issn-print Value: 09401334 Numbering: – Type: volume Value: 261 Titles: – TitleFull: European Archives of Psychiatry & Clinical Neuroscience Type: main |
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