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Sex differences in sleep after a single oral morning dose of olanzapine in healthy volunteers.

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Title: Sex differences in sleep after a single oral morning dose of olanzapine in healthy volunteers.
Authors: Giménez, Sandra, Romero, Sergio, Gich, Ignasi, Clos, Susana, Grasa, Eva, Rosa-María, Antonijoan, Barbanoj, Manuel-José
Source: Human Psychopharmacology: Clinical & Experimental. Oct2011, Vol. 26 Issue 7, p498-507. 10p.
Subjects: Polysomnography, Sleep disorder diagnosis, Sex differences (Biology), Schizophrenia, Olanzapine, Drug side effects
Abstract: Objective Polysomnography abnormalities are frequent in schizophrenia and have been correlated with clinical variables. Because women with schizophrenia present a general better clinical outcome than men, we aimed to determine whether sex differences in antipsychotic-induced effects on sleep could contribute to this difference. Methods Single oral morning doses of olanzapine (5 mg) were administered to 10 men and 10 women. Sleep variables were evaluated using traditional polysomnography Rechstschaffen and Kales criteria and all-night sleep electroencephalogram spectral analysis. Drug plasma concentrations were also measured. Results Significant sex-by-drug interactions were obtained in slow-wave sleep. After olanzapine, women showed an increase in slow-wave sleep, whereas men showed a decrease. We did not observe sex differences in olanzapine-induced hypnotic effects. Neither did we find any significant differences in pharmacokinetic parameters between sexes. Significant sex effects were observed in deep sleep, with women showing longer periods than men. Conclusion Our results showed significant pharmacodynamic differences in olanzapine sleep effects between men and women. Further studies in clinical populations are needed to assess if these sex-based differences suggest that optimal treatment and doses should differ between men and women. Copyright © 2011 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Sex differences in sleep after a single oral morning dose of olanzapine in healthy volunteers.
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  Data: <searchLink fieldCode="AR" term="%22Giménez%2C+Sandra%22">Giménez, Sandra</searchLink><br /><searchLink fieldCode="AR" term="%22Romero%2C+Sergio%22">Romero, Sergio</searchLink><br /><searchLink fieldCode="AR" term="%22Gich%2C+Ignasi%22">Gich, Ignasi</searchLink><br /><searchLink fieldCode="AR" term="%22Clos%2C+Susana%22">Clos, Susana</searchLink><br /><searchLink fieldCode="AR" term="%22Grasa%2C+Eva%22">Grasa, Eva</searchLink><br /><searchLink fieldCode="AR" term="%22Rosa-María%2C+Antonijoan%22">Rosa-María, Antonijoan</searchLink><br /><searchLink fieldCode="AR" term="%22Barbanoj%2C+Manuel-José%22">Barbanoj, Manuel-José</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Human+Psychopharmacology%3A+Clinical+%26+Experimental%22">Human Psychopharmacology: Clinical & Experimental</searchLink>. Oct2011, Vol. 26 Issue 7, p498-507. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Polysomnography%22">Polysomnography</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep+disorder+diagnosis%22">Sleep disorder diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Sex+differences+%28Biology%29%22">Sex differences (Biology)</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Olanzapine%22">Olanzapine</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+side+effects%22">Drug side effects</searchLink>
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  Data: Objective Polysomnography abnormalities are frequent in schizophrenia and have been correlated with clinical variables. Because women with schizophrenia present a general better clinical outcome than men, we aimed to determine whether sex differences in antipsychotic-induced effects on sleep could contribute to this difference. Methods Single oral morning doses of olanzapine (5 mg) were administered to 10 men and 10 women. Sleep variables were evaluated using traditional polysomnography Rechstschaffen and Kales criteria and all-night sleep electroencephalogram spectral analysis. Drug plasma concentrations were also measured. Results Significant sex-by-drug interactions were obtained in slow-wave sleep. After olanzapine, women showed an increase in slow-wave sleep, whereas men showed a decrease. We did not observe sex differences in olanzapine-induced hypnotic effects. Neither did we find any significant differences in pharmacokinetic parameters between sexes. Significant sex effects were observed in deep sleep, with women showing longer periods than men. Conclusion Our results showed significant pharmacodynamic differences in olanzapine sleep effects between men and women. Further studies in clinical populations are needed to assess if these sex-based differences suggest that optimal treatment and doses should differ between men and women. Copyright © 2011 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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