EFFECT OF AN ORAL OSMOTIC AGENT ON VENTRICULAR FLUID PRESSURE OF HYDROCEPHALIC CHILDREN.
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| Title: | EFFECT OF AN ORAL OSMOTIC AGENT ON VENTRICULAR FLUID PRESSURE OF HYDROCEPHALIC CHILDREN. |
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| Authors: | Hayden, Patricia W., Foltz, Eldon L., Shurtleff, David |
| Source: | Pediatrics. May68, Vol. 41 Issue 5, p955. 13p. |
| Subjects: | Hydrocephalus in children, Juvenile diseases |
| Abstract: | To quantitatively measure the effect of oral isosorbide on ventricular fluid pressure in hydrocephalic children, a method for continuous direct pressure recording with a closed isometric system was utilized. A baseline pressure pattern could be established for each patient, and the effect of drug could be observed with follow-through for reestablishment of baseline pressure after the last done of drug. Fourteen hydrocephalic children have been given oral isosorbide in doses varying from 1 to 3 gm per kilogram. Significant (average 50%) reduction in ventricular fluid pressure was measured in 13 of the 14 children following a single dose of isosorbide. Rebound pressure greater than baseline was measured in 5 of the 10 children given multiple doses of isosorbide. No toxic side effects were observed during the single dose studies. Clinically significant dehydration and hypernatremia began to occur after 72 hours of continuous drug administration. Serum-CSF gradient curves for drug level and osmolarity are included to show the correlation of these gradients to the ventricular fluid pressure. Pressure curves comparing the effects of intravenous urea, intravenous mannitol, and oral acetazolamide show the quantitative differences in pressure response which can be observed when the pressures are being recorded continuously with a closed system. [ABSTRACT FROM AUTHOR] |
| Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 6728013 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: EFFECT OF AN ORAL OSMOTIC AGENT ON VENTRICULAR FLUID PRESSURE OF HYDROCEPHALIC CHILDREN. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Hayden%2C+Patricia+W%2E%22">Hayden, Patricia W.</searchLink><br /><searchLink fieldCode="AR" term="%22Foltz%2C+Eldon+L%2E%22">Foltz, Eldon L.</searchLink><br /><searchLink fieldCode="AR" term="%22Shurtleff%2C+David%22">Shurtleff, David</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. May68, Vol. 41 Issue 5, p955. 13p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Hydrocephalus+in+children%22">Hydrocephalus in children</searchLink><br /><searchLink fieldCode="DE" term="%22Juvenile+diseases%22">Juvenile diseases</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: To quantitatively measure the effect of oral isosorbide on ventricular fluid pressure in hydrocephalic children, a method for continuous direct pressure recording with a closed isometric system was utilized. A baseline pressure pattern could be established for each patient, and the effect of drug could be observed with follow-through for reestablishment of baseline pressure after the last done of drug. Fourteen hydrocephalic children have been given oral isosorbide in doses varying from 1 to 3 gm per kilogram. Significant (average 50%) reduction in ventricular fluid pressure was measured in 13 of the 14 children following a single dose of isosorbide. Rebound pressure greater than baseline was measured in 5 of the 10 children given multiple doses of isosorbide. No toxic side effects were observed during the single dose studies. Clinically significant dehydration and hypernatremia began to occur after 72 hours of continuous drug administration. Serum-CSF gradient curves for drug level and osmolarity are included to show the correlation of these gradients to the ventricular fluid pressure. Pressure curves comparing the effects of intravenous urea, intravenous mannitol, and oral acetazolamide show the quantitative differences in pressure response which can be observed when the pressures are being recorded continuously with a closed system. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1542/peds.41.5.955 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 955 Subjects: – SubjectFull: Hydrocephalus in children Type: general – SubjectFull: Juvenile diseases Type: general Titles: – TitleFull: EFFECT OF AN ORAL OSMOTIC AGENT ON VENTRICULAR FLUID PRESSURE OF HYDROCEPHALIC CHILDREN. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hayden, Patricia W. – PersonEntity: Name: NameFull: Foltz, Eldon L. – PersonEntity: Name: NameFull: Shurtleff, David IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May68 Type: published Y: 1968 Identifiers: – Type: issn-print Value: 00314005 Numbering: – Type: volume Value: 41 – Type: issue Value: 5 Titles: – TitleFull: Pediatrics Type: main |
| ResultId | 1 |
