View in EDS

Is obsessive–compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective.

Saved in:
Bibliographic Details
Title: Is obsessive–compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective.
Authors: Bienvenu, O. J., Samuels, J. F., Wuyek, L. A., Liang, K.-Y., Wang, Y., Grados, M. A., Cullen, B. A., Riddle, M. A., Greenberg, B. D., Rasmussen, S. A., Fyer, A. J., Pinto, A., Rauch, S. L., Pauls, D. L., McCracken, J. T., Piacentini, J., Murphy, D. L., Knowles, J. A., Nestadt, G.
Source: Psychological Medicine. Jan2012, Vol. 42 Issue 1, p1-13. 13p.
Subjects: Chi-squared test, Comparative studies, Epidemiology, Fisher exact test, Interviewing, Research methodology, Classification of mental disorders, Obsessive-compulsive disorder, Personality disorders, Research funding, Comorbidity, Logistic regression analysis, Data analysis, Anxiety disorders, Disease prevalence, Genetics
Abstract: BackgroundExperts have proposed removing obsessive–compulsive disorder (OCD) from the anxiety disorders section and grouping it with putatively related conditions in DSM-5. The current study uses co-morbidity and familiality data to inform these issues.MethodCase family data from the OCD Collaborative Genetics Study (382 OCD-affected probands and 974 of their first-degree relatives) were compared with control family data from the Johns Hopkins OCD Family Study (73 non-OCD-affected probands and 233 of their first-degree relatives).ResultsAnxiety disorders (especially agoraphobia and generalized anxiety disorder), cluster C personality disorders (especially obsessive–compulsive and avoidant), tic disorders, somatoform disorders (hypochondriasis and body dysmorphic disorder), grooming disorders (especially trichotillomania and pathological skin picking) and mood disorders (especially unipolar depressive disorders) were more common in case than control probands; however, the prevalences of eating disorders (anorexia and bulimia nervosa), other impulse-control disorders (pathological gambling, pyromania, kleptomania) and substance dependence (alcohol or drug) did not differ between the groups. The same general pattern was evident in relatives of case versus control probands. Results in relatives did not differ markedly when adjusted for demographic variables and proband diagnosis of the same disorder, though the strength of associations was lower when adjusted for OCD in relatives. Nevertheless, several anxiety, depressive and putative OCD-related conditions remained significantly more common in case than control relatives when adjusting for all of these variables simultaneously.ConclusionsOn the basis of co-morbidity and familiality, OCD appears related both to anxiety disorders and to some conditions currently classified in other sections of DSM-IV. [ABSTRACT FROM PUBLISHER]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 67512523
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Is obsessive–compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Bienvenu%2C+O%2E+J%2E%22">Bienvenu, O. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Samuels%2C+J%2E+F%2E%22">Samuels, J. F.</searchLink><br /><searchLink fieldCode="AR" term="%22Wuyek%2C+L%2E+A%2E%22">Wuyek, L. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Liang%2C+K%2E-Y%2E%22">Liang, K.-Y.</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+Y%2E%22">Wang, Y.</searchLink><br /><searchLink fieldCode="AR" term="%22Grados%2C+M%2E+A%2E%22">Grados, M. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Cullen%2C+B%2E+A%2E%22">Cullen, B. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Riddle%2C+M%2E+A%2E%22">Riddle, M. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Greenberg%2C+B%2E+D%2E%22">Greenberg, B. D.</searchLink><br /><searchLink fieldCode="AR" term="%22Rasmussen%2C+S%2E+A%2E%22">Rasmussen, S. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Fyer%2C+A%2E+J%2E%22">Fyer, A. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Pinto%2C+A%2E%22">Pinto, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Rauch%2C+S%2E+L%2E%22">Rauch, S. L.</searchLink><br /><searchLink fieldCode="AR" term="%22Pauls%2C+D%2E+L%2E%22">Pauls, D. L.</searchLink><br /><searchLink fieldCode="AR" term="%22McCracken%2C+J%2E+T%2E%22">McCracken, J. T.</searchLink><br /><searchLink fieldCode="AR" term="%22Piacentini%2C+J%2E%22">Piacentini, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Murphy%2C+D%2E+L%2E%22">Murphy, D. L.</searchLink><br /><searchLink fieldCode="AR" term="%22Knowles%2C+J%2E+A%2E%22">Knowles, J. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Nestadt%2C+G%2E%22">Nestadt, G.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Jan2012, Vol. 42 Issue 1, p1-13. 13p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Chi-squared+test%22">Chi-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Epidemiology%22">Epidemiology</searchLink><br /><searchLink fieldCode="DE" term="%22Fisher+exact+test%22">Fisher exact test</searchLink><br /><searchLink fieldCode="DE" term="%22Interviewing%22">Interviewing</searchLink><br /><searchLink fieldCode="DE" term="%22Research+methodology%22">Research methodology</searchLink><br /><searchLink fieldCode="DE" term="%22Classification+of+mental+disorders%22">Classification of mental disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Obsessive-compulsive+disorder%22">Obsessive-compulsive disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Personality+disorders%22">Personality disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Comorbidity%22">Comorbidity</searchLink><br /><searchLink fieldCode="DE" term="%22Logistic+regression+analysis%22">Logistic regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis%22">Data analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety+disorders%22">Anxiety disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+prevalence%22">Disease prevalence</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: BackgroundExperts have proposed removing obsessive–compulsive disorder (OCD) from the anxiety disorders section and grouping it with putatively related conditions in DSM-5. The current study uses co-morbidity and familiality data to inform these issues.MethodCase family data from the OCD Collaborative Genetics Study (382 OCD-affected probands and 974 of their first-degree relatives) were compared with control family data from the Johns Hopkins OCD Family Study (73 non-OCD-affected probands and 233 of their first-degree relatives).ResultsAnxiety disorders (especially agoraphobia and generalized anxiety disorder), cluster C personality disorders (especially obsessive–compulsive and avoidant), tic disorders, somatoform disorders (hypochondriasis and body dysmorphic disorder), grooming disorders (especially trichotillomania and pathological skin picking) and mood disorders (especially unipolar depressive disorders) were more common in case than control probands; however, the prevalences of eating disorders (anorexia and bulimia nervosa), other impulse-control disorders (pathological gambling, pyromania, kleptomania) and substance dependence (alcohol or drug) did not differ between the groups. The same general pattern was evident in relatives of case versus control probands. Results in relatives did not differ markedly when adjusted for demographic variables and proband diagnosis of the same disorder, though the strength of associations was lower when adjusted for OCD in relatives. Nevertheless, several anxiety, depressive and putative OCD-related conditions remained significantly more common in case than control relatives when adjusting for all of these variables simultaneously.ConclusionsOn the basis of co-morbidity and familiality, OCD appears related both to anxiety disorders and to some conditions currently classified in other sections of DSM-IV. [ABSTRACT FROM PUBLISHER]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=67512523
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1017/S0033291711000742
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 13
        StartPage: 1
    Subjects:
      – SubjectFull: Chi-squared test
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Epidemiology
        Type: general
      – SubjectFull: Fisher exact test
        Type: general
      – SubjectFull: Interviewing
        Type: general
      – SubjectFull: Research methodology
        Type: general
      – SubjectFull: Classification of mental disorders
        Type: general
      – SubjectFull: Obsessive-compulsive disorder
        Type: general
      – SubjectFull: Personality disorders
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Comorbidity
        Type: general
      – SubjectFull: Logistic regression analysis
        Type: general
      – SubjectFull: Data analysis
        Type: general
      – SubjectFull: Anxiety disorders
        Type: general
      – SubjectFull: Disease prevalence
        Type: general
      – SubjectFull: Genetics
        Type: general
    Titles:
      – TitleFull: Is obsessive–compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Bienvenu, O. J.
      – PersonEntity:
          Name:
            NameFull: Samuels, J. F.
      – PersonEntity:
          Name:
            NameFull: Wuyek, L. A.
      – PersonEntity:
          Name:
            NameFull: Liang, K.-Y.
      – PersonEntity:
          Name:
            NameFull: Wang, Y.
      – PersonEntity:
          Name:
            NameFull: Grados, M. A.
      – PersonEntity:
          Name:
            NameFull: Cullen, B. A.
      – PersonEntity:
          Name:
            NameFull: Riddle, M. A.
      – PersonEntity:
          Name:
            NameFull: Greenberg, B. D.
      – PersonEntity:
          Name:
            NameFull: Rasmussen, S. A.
      – PersonEntity:
          Name:
            NameFull: Fyer, A. J.
      – PersonEntity:
          Name:
            NameFull: Pinto, A.
      – PersonEntity:
          Name:
            NameFull: Rauch, S. L.
      – PersonEntity:
          Name:
            NameFull: Pauls, D. L.
      – PersonEntity:
          Name:
            NameFull: McCracken, J. T.
      – PersonEntity:
          Name:
            NameFull: Piacentini, J.
      – PersonEntity:
          Name:
            NameFull: Murphy, D. L.
      – PersonEntity:
          Name:
            NameFull: Knowles, J. A.
      – PersonEntity:
          Name:
            NameFull: Nestadt, G.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Text: Jan2012
              Type: published
              Y: 2012
          Identifiers:
            – Type: issn-print
              Value: 00332917
          Numbering:
            – Type: volume
              Value: 42
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Psychological Medicine
              Type: main
ResultId 1