Enoxaparin vs heparin for prevention of deep-vein thrombosis in acute ischaemic stroke: a randomized, double-blind study.
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| Title: | Enoxaparin vs heparin for prevention of deep-vein thrombosis in acute ischaemic stroke: a randomized, double-blind study. |
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| Authors: | Hillbom, M, Erilä, T, Sotaniemi, K, Tatlisumak, T, Sarna, S, Kaste, M |
| Source: | Acta Neurologica Scandinavica. Aug2002, Vol. 106 Issue 2, p84-92. 9p. |
| Subjects: | Venous thrombosis prevention, Heparin, Cerebrovascular disease |
| Abstract: | Objectives – To compare the efficacy, safety, and overall risk–benefit profile of enoxaparin and unfractionated heparin (UFH) prophylaxis of venous thromboembolic complications in patients with acute ischaemic stroke. Methods – Patients with ischaemic stroke resulting in lower-limb paralysis lasting for at least 24 h and necessitating bedrest, were randomized within 48 h of the onset of stroke, and treated with enoxaparin (40 mg subcutaneously once daily) or UFH (5000 IU subcutaneously thrice daily) for 10 ± 2 days. Main outcome measures were deep-vein thrombosis, pulmonary embolism (PE), death from any cause, intracranial haemorrhage including haemorrhagic infarction, or any other major bleeding. Results – Outcome events occurred within 3 months of stroke in 40/106 patients treated with enoxaparin (37.7%) and 52/106 patients treated with UFH (49.1%, P =0.127). Fewer patients treated with enoxaparin (14, 13.2%) than with UFH (20, 18.9%) had evidence of haemorrhagic transformation of ischaemic stroke. Conclusions – Enoxaparin administered subcutaneously once daily was as safe and effective as subcutaneous UFH given thrice daily in the prevention of thromboembolic events in patients with lower limb paralysis caused by acute ischaemic stroke. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 6894840 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Enoxaparin vs heparin for prevention of deep-vein thrombosis in acute ischaemic stroke: a randomized, double-blind study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Hillbom%2C+M%22">Hillbom, M</searchLink><br /><searchLink fieldCode="AR" term="%22Erilä%2C+T%22">Erilä, T</searchLink><br /><searchLink fieldCode="AR" term="%22Sotaniemi%2C+K%22">Sotaniemi, K</searchLink><br /><searchLink fieldCode="AR" term="%22Tatlisumak%2C+T%22">Tatlisumak, T</searchLink><br /><searchLink fieldCode="AR" term="%22Sarna%2C+S%22">Sarna, S</searchLink><br /><searchLink fieldCode="AR" term="%22Kaste%2C+M%22">Kaste, M</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. Aug2002, Vol. 106 Issue 2, p84-92. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Venous+thrombosis+prevention%22">Venous thrombosis prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Heparin%22">Heparin</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebrovascular+disease%22">Cerebrovascular disease</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objectives – To compare the efficacy, safety, and overall risk–benefit profile of enoxaparin and unfractionated heparin (UFH) prophylaxis of venous thromboembolic complications in patients with acute ischaemic stroke. Methods – Patients with ischaemic stroke resulting in lower-limb paralysis lasting for at least 24 h and necessitating bedrest, were randomized within 48 h of the onset of stroke, and treated with enoxaparin (40 mg subcutaneously once daily) or UFH (5000 IU subcutaneously thrice daily) for 10 ± 2 days. Main outcome measures were deep-vein thrombosis, pulmonary embolism (PE), death from any cause, intracranial haemorrhage including haemorrhagic infarction, or any other major bleeding. Results – Outcome events occurred within 3 months of stroke in 40/106 patients treated with enoxaparin (37.7%) and 52/106 patients treated with UFH (49.1%, P =0.127). Fewer patients treated with enoxaparin (14, 13.2%) than with UFH (20, 18.9%) had evidence of haemorrhagic transformation of ischaemic stroke. Conclusions – Enoxaparin administered subcutaneously once daily was as safe and effective as subcutaneous UFH given thrice daily in the prevention of thromboembolic events in patients with lower limb paralysis caused by acute ischaemic stroke. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1034/j.1600-0404.2002.01215.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 84 Subjects: – SubjectFull: Venous thrombosis prevention Type: general – SubjectFull: Heparin Type: general – SubjectFull: Cerebrovascular disease Type: general Titles: – TitleFull: Enoxaparin vs heparin for prevention of deep-vein thrombosis in acute ischaemic stroke: a randomized, double-blind study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hillbom, M – PersonEntity: Name: NameFull: Erilä, T – PersonEntity: Name: NameFull: Sotaniemi, K – PersonEntity: Name: NameFull: Tatlisumak, T – PersonEntity: Name: NameFull: Sarna, S – PersonEntity: Name: NameFull: Kaste, M IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2002 Type: published Y: 2002 Identifiers: – Type: issn-print Value: 00016314 Numbering: – Type: volume Value: 106 – Type: issue Value: 2 Titles: – TitleFull: Acta Neurologica Scandinavica Type: main |
| ResultId | 1 |
