Effects of intralaminar thalamic nuclei lesion on glutamic acid decarboxylase (GAD65 and GAD67) and cytochrome oxidase subunit I mRNA expression in the basal ganglia of the rat.
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| Title: | Effects of intralaminar thalamic nuclei lesion on glutamic acid decarboxylase (GAD65 and GAD67) and cytochrome oxidase subunit I mRNA expression in the basal ganglia of the rat. |
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| Authors: | Bacci, Jean‐Jacques (AUTHOR), Kerkerian‐Le Goff, Lydia (AUTHOR), Salin, Pascal (AUTHOR) |
| Source: | European Journal of Neuroscience. Jun2002, Vol. 15 Issue 12, p1918-1928. 11p. 2 Charts. |
| Subjects: | Thalamus, Precancerous conditions, Glutamate decarboxylase, Cytochrome oxidase, Basal ganglia |
| Abstract: | This study investigated the influence of thalamic inputs on neuronal metabolic activity in the rat basal ganglia. By means of in situ hybridization histochemistry, we examined the consequences of ibotenate-induced unilateral lesion of intralaminar thalamic nuclei on mRNA expression of cytochrome oxidase subunit-I (CoI) in the striatum and the subthalamic nucleus (STN) and of the two isoforms of glutamate decarboxylase (GAD65 and GAD67) in the striatum, globus pallidus (GP), entopeduncular nucleus (EP) and substantia nigra pars reticulata (SNr). In the striatum, GAD67 mRNA expression decreased selectively in the rostral part of the structure at 5 and 12 days postlesion (≈ -30%), whereas, GAD65 mRNA levels was downregulated only in the caudal striatum at 12 days (-29%). In both the striatum and STN, CoI mRNA expression decreased ipsilaterally at 5 and bilaterally at 12 days. In GP, GAD67 and GAD65 mRNA expression decreased ipsilaterally at 5 (-20% and -26%) and 12 days (-23% and 36%). In EP, selective bilateral decreases in GAD67 mRNA expression were found at 5 and 12 days (-50% and -40%). Conversely, in SNr, only GAD65 mRNA expression was reduced bilaterally at both time points. These data show that the thalamus exerts a widespread excitatory influence on the basal ganglia network that cannot be accounted for solely by its known direct connections. Given the recent data showing that intralaminar thalamic nuclei are a major nondopaminergic site of neurodegeneration in Parkinson's disease, these results may have a critical bearing on understanding the cellular basis of basal ganglia dysfunction in parkinsonism. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 6928703 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effects of intralaminar thalamic nuclei lesion on glutamic acid decarboxylase (GAD65 and GAD67) and cytochrome oxidase subunit I mRNA expression in the basal ganglia of the rat. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Bacci%2C+Jean‐Jacques%22">Bacci, Jean‐Jacques</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kerkerian‐Le+Goff%2C+Lydia%22">Kerkerian‐Le Goff, Lydia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Salin%2C+Pascal%22">Salin, Pascal</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Jun2002, Vol. 15 Issue 12, p1918-1928. 11p. 2 Charts. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Thalamus%22">Thalamus</searchLink><br /><searchLink fieldCode="DE" term="%22Precancerous+conditions%22">Precancerous conditions</searchLink><br /><searchLink fieldCode="DE" term="%22Glutamate+decarboxylase%22">Glutamate decarboxylase</searchLink><br /><searchLink fieldCode="DE" term="%22Cytochrome+oxidase%22">Cytochrome oxidase</searchLink><br /><searchLink fieldCode="DE" term="%22Basal+ganglia%22">Basal ganglia</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: This study investigated the influence of thalamic inputs on neuronal metabolic activity in the rat basal ganglia. By means of in situ hybridization histochemistry, we examined the consequences of ibotenate-induced unilateral lesion of intralaminar thalamic nuclei on mRNA expression of cytochrome oxidase subunit-I (CoI) in the striatum and the subthalamic nucleus (STN) and of the two isoforms of glutamate decarboxylase (GAD65 and GAD67) in the striatum, globus pallidus (GP), entopeduncular nucleus (EP) and substantia nigra pars reticulata (SNr). In the striatum, GAD67 mRNA expression decreased selectively in the rostral part of the structure at 5 and 12 days postlesion (≈ -30%), whereas, GAD65 mRNA levels was downregulated only in the caudal striatum at 12 days (-29%). In both the striatum and STN, CoI mRNA expression decreased ipsilaterally at 5 and bilaterally at 12 days. In GP, GAD67 and GAD65 mRNA expression decreased ipsilaterally at 5 (-20% and -26%) and 12 days (-23% and 36%). In EP, selective bilateral decreases in GAD67 mRNA expression were found at 5 and 12 days (-50% and -40%). Conversely, in SNr, only GAD65 mRNA expression was reduced bilaterally at both time points. These data show that the thalamus exerts a widespread excitatory influence on the basal ganglia network that cannot be accounted for solely by its known direct connections. Given the recent data showing that intralaminar thalamic nuclei are a major nondopaminergic site of neurodegeneration in Parkinson's disease, these results may have a critical bearing on understanding the cellular basis of basal ganglia dysfunction in parkinsonism. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1046/j.1460-9568.2002.02039.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1918 Subjects: – SubjectFull: Thalamus Type: general – SubjectFull: Precancerous conditions Type: general – SubjectFull: Glutamate decarboxylase Type: general – SubjectFull: Cytochrome oxidase Type: general – SubjectFull: Basal ganglia Type: general Titles: – TitleFull: Effects of intralaminar thalamic nuclei lesion on glutamic acid decarboxylase (GAD65 and GAD67) and cytochrome oxidase subunit I mRNA expression in the basal ganglia of the rat. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bacci, Jean‐Jacques – PersonEntity: Name: NameFull: Kerkerian‐Le Goff, Lydia – PersonEntity: Name: NameFull: Salin, Pascal IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 06 Text: Jun2002 Type: published Y: 2002 Identifiers: – Type: issn-print Value: 0953816X Numbering: – Type: volume Value: 15 – Type: issue Value: 12 Titles: – TitleFull: European Journal of Neuroscience Type: main |
| ResultId | 1 |
