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SHORT COMMUNICATION Novelty enhances retrieval: molecular mechanisms involved in rat hippocampus.

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Title: SHORT COMMUNICATION Novelty enhances retrieval: molecular mechanisms involved in rat hippocampus.
Authors: Izquierdo, L. A. (AUTHOR), Viola, H. (AUTHOR), Barros, D. M. (AUTHOR), Alonso, M. (AUTHOR), Vianna, M. R. M. (AUTHOR), Furman, M. (AUTHOR), Levi de Stein, M. (AUTHOR), Szapiro, G. (AUTHOR), Rodrigues, C. (AUTHOR), Choi, H. (AUTHOR), Medina, J. H. (AUTHOR), Izquierdo, I. (AUTHOR)
Source: European Journal of Neuroscience. Apr2001, Vol. 13 Issue 7, p1464-1467. 4p. 1 Map.
Subjects: Neurosciences, Protein kinases, Memory, Acclimatization
Abstract: Rats exposed to a novel environment just prior to or 1-2 h, but not 4 or 6 h, before retention testing exhibited an enhanced retrieval of a one-trial inhibitory avoidance training. The bilateral intrahippocampal infusion of PD098059, an inhibitor of mitogenactivated protein kinase (MAPK), the specific upstream activator of p42 and p44 MAPKs, given 10 min before the exposure to the novel environment, blocked the enhancing effect of novelty on memory retrieval. In addition, prenovelty infusion of DL-2amino-5-phosphonovalerate (APV), an antagonist of glutamate NMDA receptors, produced similar effects. The exposure to the novel environment is associated with an activation of p42 and p44 MAPKs and an increase in the phosphorylation state of the transcription factor cAMP response element binding protein (CREB). No changes were observed in cAMP-dependent protein kinase (PKA) activity or in α-CAMKII activation. Taken together, our results indicate that novelty activates hippocampal MAPKs, which are necessary, along with glutamate NMDA receptors, for the enhancing effect of novelty on retrieval. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: SHORT COMMUNICATION Novelty enhances retrieval: molecular mechanisms involved in rat hippocampus.
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  Data: <searchLink fieldCode="AR" term="%22Izquierdo%2C+L%2E+A%2E%22">Izquierdo, L. A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Viola%2C+H%2E%22">Viola, H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barros%2C+D%2E+M%2E%22">Barros, D. M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Alonso%2C+M%2E%22">Alonso, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vianna%2C+M%2E+R%2E+M%2E%22">Vianna, M. R. M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Furman%2C+M%2E%22">Furman, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Levi+de+Stein%2C+M%2E%22">Levi de Stein, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Szapiro%2C+G%2E%22">Szapiro, G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rodrigues%2C+C%2E%22">Rodrigues, C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Choi%2C+H%2E%22">Choi, H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Medina%2C+J%2E+H%2E%22">Medina, J. H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Izquierdo%2C+I%2E%22">Izquierdo, I.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Apr2001, Vol. 13 Issue 7, p1464-1467. 4p. 1 Map.
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  Data: <searchLink fieldCode="DE" term="%22Neurosciences%22">Neurosciences</searchLink><br /><searchLink fieldCode="DE" term="%22Protein+kinases%22">Protein kinases</searchLink><br /><searchLink fieldCode="DE" term="%22Memory%22">Memory</searchLink><br /><searchLink fieldCode="DE" term="%22Acclimatization%22">Acclimatization</searchLink>
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  Data: Rats exposed to a novel environment just prior to or 1-2 h, but not 4 or 6 h, before retention testing exhibited an enhanced retrieval of a one-trial inhibitory avoidance training. The bilateral intrahippocampal infusion of PD098059, an inhibitor of mitogenactivated protein kinase (MAPK), the specific upstream activator of p42 and p44 MAPKs, given 10 min before the exposure to the novel environment, blocked the enhancing effect of novelty on memory retrieval. In addition, prenovelty infusion of DL-2amino-5-phosphonovalerate (APV), an antagonist of glutamate NMDA receptors, produced similar effects. The exposure to the novel environment is associated with an activation of p42 and p44 MAPKs and an increase in the phosphorylation state of the transcription factor cAMP response element binding protein (CREB). No changes were observed in cAMP-dependent protein kinase (PKA) activity or in α-CAMKII activation. Taken together, our results indicate that novelty activates hippocampal MAPKs, which are necessary, along with glutamate NMDA receptors, for the enhancing effect of novelty on retrieval. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1046/j.0953-816x.2001.01530.x
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      – SubjectFull: Protein kinases
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      – SubjectFull: Acclimatization
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              Text: Apr2001
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