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Specificity of the Tuberculin Skin Test and the T-SPOT. TB Assay Among Students in a Low–Tuberculosis Incidence Setting.

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Title: Specificity of the Tuberculin Skin Test and the T-SPOT. TB Assay Among Students in a Low–Tuberculosis Incidence Setting.
Authors: Talbot, ElizabethA. (AUTHOR), Harland, Dawn (AUTHOR), Wieland-Alter, Wendy (AUTHOR), Burrer, Sherry (AUTHOR), Adams, LisaV. (AUTHOR)
Source: Journal of American College Health. Jan2012, Vol. 60 Issue 1, p94-96. 3p. 1 Chart.
Subjects: Biological assay, Blood testing, Services for college students, Comparative studies, Confidence intervals, Cost effectiveness, Interferons, Questionnaires, Research funding, Risk assessment, Skin tests, Statistics, Tuberculin test, Health of college students
Abstract: Objective: Interferon-γ release assays (IGRAs) are an important tool for detecting latent Mycobacterium tuberculosis infection (LTBI). Insufficient data exist about IGRA specificity in college health centers, most of which screen students for LTBI using the tuberculin skin test (TST). Participants: Students at a low–TB incidence college health center. Methods: TST and T-SPOT.TB were performed on prospectively recruited students. TB exposure risk was assessed using a questionnaire: Those at low risk were assumed to not have LTBI in order to calculate test specificity. Results: Of 184 students enrolled, 143 had results available for both TST and T-SPOT.TB. Agreement of the tests was 97% (kappa statistic 0.717; 95% confidence interval, 0.399–1.00). Among 124 low-risk students, specificity for TST and T-SPOT.TB were 98.4% and 100%, respectively. Conclusions: T-SPOT.TB specificity was high among low-risk students. Additional studies such as cost-effectiveness analyses using T-SPOT.TB as a single or confirmatory test to TST are needed to contribute to LTBI screening policy decisions. [ABSTRACT FROM PUBLISHER]
Copyright of Journal of American College Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Specificity of the Tuberculin Skin Test and the T-SPOT. TB Assay Among Students in a Low–Tuberculosis Incidence Setting.
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  Data: <searchLink fieldCode="AR" term="%22Talbot%2C+ElizabethA%2E%22">Talbot, ElizabethA.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Harland%2C+Dawn%22">Harland, Dawn</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wieland-Alter%2C+Wendy%22">Wieland-Alter, Wendy</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burrer%2C+Sherry%22">Burrer, Sherry</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Adams%2C+LisaV%2E%22">Adams, LisaV.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="DE" term="%22Biological+assay%22">Biological assay</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+testing%22">Blood testing</searchLink><br /><searchLink fieldCode="DE" term="%22Services+for+college+students%22">Services for college students</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Cost+effectiveness%22">Cost effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Interferons%22">Interferons</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Skin+tests%22">Skin tests</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Tuberculin+test%22">Tuberculin test</searchLink><br /><searchLink fieldCode="DE" term="%22Health+of+college+students%22">Health of college students</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: Interferon-γ release assays (IGRAs) are an important tool for detecting latent Mycobacterium tuberculosis infection (LTBI). Insufficient data exist about IGRA specificity in college health centers, most of which screen students for LTBI using the tuberculin skin test (TST). Participants: Students at a low–TB incidence college health center. Methods: TST and T-SPOT.TB were performed on prospectively recruited students. TB exposure risk was assessed using a questionnaire: Those at low risk were assumed to not have LTBI in order to calculate test specificity. Results: Of 184 students enrolled, 143 had results available for both TST and T-SPOT.TB. Agreement of the tests was 97% (kappa statistic 0.717; 95% confidence interval, 0.399–1.00). Among 124 low-risk students, specificity for TST and T-SPOT.TB were 98.4% and 100%, respectively. Conclusions: T-SPOT.TB specificity was high among low-risk students. Additional studies such as cost-effectiveness analyses using T-SPOT.TB as a single or confirmatory test to TST are needed to contribute to LTBI screening policy decisions. [ABSTRACT FROM PUBLISHER]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of American College Health is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/07448481.2011.580029
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 3
        StartPage: 94
    Subjects:
      – SubjectFull: Biological assay
        Type: general
      – SubjectFull: Blood testing
        Type: general
      – SubjectFull: Services for college students
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Cost effectiveness
        Type: general
      – SubjectFull: Interferons
        Type: general
      – SubjectFull: Questionnaires
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Skin tests
        Type: general
      – SubjectFull: Statistics
        Type: general
      – SubjectFull: Tuberculin test
        Type: general
      – SubjectFull: Health of college students
        Type: general
    Titles:
      – TitleFull: Specificity of the Tuberculin Skin Test and the T-SPOT. TB Assay Among Students in a Low–Tuberculosis Incidence Setting.
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            NameFull: Talbot, ElizabethA.
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              Text: Jan2012
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              Y: 2012
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