Epilepsy: fractures and the role of cumulative antiepileptic drug load.
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| Title: | Epilepsy: fractures and the role of cumulative antiepileptic drug load. |
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| Authors: | Beerhorst, K., Schouwenaars, F. M., Tan, I. Y., Aldenkamp, A. P. |
| Source: | Acta Neurologica Scandinavica. Jan2012, Vol. 125 Issue 1, p54-59. 6p. |
| Subjects: | Epilepsy, Bone fractures, Anticonvulsants, Bone density, Metabolic bone disorders, Osteoporosis, Diphosphonates |
| Abstract: | Beerhorst K, Schouwenaars FM, Tan IY, Aldenkamp AP. Epilepsy: fractures and the role of cumulative antiepileptic drug load. Acta Neurol Scand: 2012: 125: 54-59. © 2011 John Wiley & Sons A/S. Background- An association between antiepileptic drugs (AEDs), low bone mineral density (BMD), fractures, and abnormalities in bone metabolism has been suggested for a longer period, although conclusive evidence has not been reported. We aimed at studying patient characteristics in a high-risk population. Methods - All adult patients from a residential unit of a tertiary epilepsy center who were diagnosed with osteoporosis and consequently treated with a bisphosphonate at that moment were included. Correlations between reported fractures and patient characteristics were explored. Results - Of the total population of 261 adult patients, 54 patients were included resulting in a high prevalence rate of 21% osteoporosis in this population. The number of fractures correlated significantly with ambulatory status ( r = −0.269, P = 0.05), drug load ( r = 0.286, P = 0.04), and current number of AEDs ( r = 0.283, P = 0.04). Correlations could not be provided for individual drugs in our population as only a minority was on monotherapy and even less patients had always been on monotherapy of the same antiepileptic drug. Linear regression analysis showed that cumulative drug load (defined by a surrogate parameter: the total duration of epilepsy multiplied by the number of AEDs) was the dominant factor explaining the occurrence of fractures. Conclusion - In this high-risk population, we obtained a positive and strong correlation between the occurrence of fractures in a diagnosed population with osteoporosis and the cumulative drug load of AEDs. This effect seems general, independent of the type of AEDs that were used. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 69870754 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Epilepsy: fractures and the role of cumulative antiepileptic drug load. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Beerhorst%2C+K%2E%22">Beerhorst, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Schouwenaars%2C+F%2E+M%2E%22">Schouwenaars, F. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Tan%2C+I%2E+Y%2E%22">Tan, I. Y.</searchLink><br /><searchLink fieldCode="AR" term="%22Aldenkamp%2C+A%2E+P%2E%22">Aldenkamp, A. P.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. Jan2012, Vol. 125 Issue 1, p54-59. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Epilepsy%22">Epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+fractures%22">Bone fractures</searchLink><br /><searchLink fieldCode="DE" term="%22Anticonvulsants%22">Anticonvulsants</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+density%22">Bone density</searchLink><br /><searchLink fieldCode="DE" term="%22Metabolic+bone+disorders%22">Metabolic bone disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Osteoporosis%22">Osteoporosis</searchLink><br /><searchLink fieldCode="DE" term="%22Diphosphonates%22">Diphosphonates</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Beerhorst K, Schouwenaars FM, Tan IY, Aldenkamp AP. Epilepsy: fractures and the role of cumulative antiepileptic drug load. Acta Neurol Scand: 2012: 125: 54-59. © 2011 John Wiley & Sons A/S. Background- An association between antiepileptic drugs (AEDs), low bone mineral density (BMD), fractures, and abnormalities in bone metabolism has been suggested for a longer period, although conclusive evidence has not been reported. We aimed at studying patient characteristics in a high-risk population. Methods - All adult patients from a residential unit of a tertiary epilepsy center who were diagnosed with osteoporosis and consequently treated with a bisphosphonate at that moment were included. Correlations between reported fractures and patient characteristics were explored. Results - Of the total population of 261 adult patients, 54 patients were included resulting in a high prevalence rate of 21% osteoporosis in this population. The number of fractures correlated significantly with ambulatory status ( r = −0.269, P = 0.05), drug load ( r = 0.286, P = 0.04), and current number of AEDs ( r = 0.283, P = 0.04). Correlations could not be provided for individual drugs in our population as only a minority was on monotherapy and even less patients had always been on monotherapy of the same antiepileptic drug. Linear regression analysis showed that cumulative drug load (defined by a surrogate parameter: the total duration of epilepsy multiplied by the number of AEDs) was the dominant factor explaining the occurrence of fractures. Conclusion - In this high-risk population, we obtained a positive and strong correlation between the occurrence of fractures in a diagnosed population with osteoporosis and the cumulative drug load of AEDs. This effect seems general, independent of the type of AEDs that were used. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/j.1600-0404.2011.01509.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 54 Subjects: – SubjectFull: Epilepsy Type: general – SubjectFull: Bone fractures Type: general – SubjectFull: Anticonvulsants Type: general – SubjectFull: Bone density Type: general – SubjectFull: Metabolic bone disorders Type: general – SubjectFull: Osteoporosis Type: general – SubjectFull: Diphosphonates Type: general Titles: – TitleFull: Epilepsy: fractures and the role of cumulative antiepileptic drug load. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Beerhorst, K. – PersonEntity: Name: NameFull: Schouwenaars, F. M. – PersonEntity: Name: NameFull: Tan, I. Y. – PersonEntity: Name: NameFull: Aldenkamp, A. P. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2012 Type: published Y: 2012 Identifiers: – Type: issn-print Value: 00016314 Numbering: – Type: volume Value: 125 – Type: issue Value: 1 Titles: – TitleFull: Acta Neurologica Scandinavica Type: main |
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