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Midazolam-induced Amnesia Reduces Memory for Details and Affects the ERP Correlates of Recollection and Familiarity.

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Title: Midazolam-induced Amnesia Reduces Memory for Details and Affects the ERP Correlates of Recollection and Familiarity.
Authors: Nyhus, Erika, Curran, Tim
Source: Journal of Cognitive Neuroscience. Feb2012, Vol. 24 Issue 2, p416-427. 12p.
Subjects: Midazolam, Amnesia, Memory loss, Recollection (Psychology), Familiarity (Psychology), Evoked potentials (Electrophysiology)
Abstract: Dual process models suggest that recognition memory is supported by familiarity and recollection processes. Previous research administering amnesic drugs and measuring ERPs during recognition memory have provided evidence for separable neural correlates of familiarity and recollection. This study examined the effect of midazolam-induced amnesia on memory for details and the proposed ERP correlates of recognition. Midazolam or saline was administered while subjects studied oriented pictures of common objects. ERPs were recorded during a recognition test 1 day later. Subjects' discrimination of old and new pictures as well as orientation discrimination was worse when they were given midazolam instead of saline. As predicted, the parietal old/new effect was decreased with the administration of midazolam. However, weaker effects on FN400 old/new effects were also observed. These results provide converging pharmacological and electrophysiological evidence that midazolam primarily affects recollection as indexed by parietal ERP old/new effects and memory for orientation, while also exerting some weaker effects on familiarity as indexed by FN400 old/new effects. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Cognitive Neuroscience is the property of MIT Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Midazolam-induced Amnesia Reduces Memory for Details and Affects the ERP Correlates of Recollection and Familiarity.
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  Data: <searchLink fieldCode="AR" term="%22Nyhus%2C+Erika%22">Nyhus, Erika</searchLink><br /><searchLink fieldCode="AR" term="%22Curran%2C+Tim%22">Curran, Tim</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Cognitive+Neuroscience%22">Journal of Cognitive Neuroscience</searchLink>. Feb2012, Vol. 24 Issue 2, p416-427. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Midazolam%22">Midazolam</searchLink><br /><searchLink fieldCode="DE" term="%22Amnesia%22">Amnesia</searchLink><br /><searchLink fieldCode="DE" term="%22Memory+loss%22">Memory loss</searchLink><br /><searchLink fieldCode="DE" term="%22Recollection+%28Psychology%29%22">Recollection (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Familiarity+%28Psychology%29%22">Familiarity (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Evoked+potentials+%28Electrophysiology%29%22">Evoked potentials (Electrophysiology)</searchLink>
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  Data: Dual process models suggest that recognition memory is supported by familiarity and recollection processes. Previous research administering amnesic drugs and measuring ERPs during recognition memory have provided evidence for separable neural correlates of familiarity and recollection. This study examined the effect of midazolam-induced amnesia on memory for details and the proposed ERP correlates of recognition. Midazolam or saline was administered while subjects studied oriented pictures of common objects. ERPs were recorded during a recognition test 1 day later. Subjects' discrimination of old and new pictures as well as orientation discrimination was worse when they were given midazolam instead of saline. As predicted, the parietal old/new effect was decreased with the administration of midazolam. However, weaker effects on FN400 old/new effects were also observed. These results provide converging pharmacological and electrophysiological evidence that midazolam primarily affects recollection as indexed by parietal ERP old/new effects and memory for orientation, while also exerting some weaker effects on familiarity as indexed by FN400 old/new effects. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Cognitive Neuroscience is the property of MIT Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1162/jocn_a_00154
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      – SubjectFull: Midazolam
        Type: general
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      – SubjectFull: Memory loss
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      – SubjectFull: Recollection (Psychology)
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      – SubjectFull: Familiarity (Psychology)
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              Text: Feb2012
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