Resting leukocyte telomerase activity is elevated in major depression and predicts treatment response.
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| Title: | Resting leukocyte telomerase activity is elevated in major depression and predicts treatment response. |
|---|---|
| Authors: | Wolkowitz, O M, Mellon, S H, Epel, E S, Lin, J, Reus, V I, Rosser, R, Burke, H, Compagnone, M, Nelson, J C, Dhabhar, F S, Blackburn, E H |
| Source: | Molecular Psychiatry. Feb2012, Vol. 17 Issue 2, p164-172. 9p. 1 Chart, 4 Graphs. |
| Subjects: | Telomerase, Leukocytes, Therapeutics, Mental depression, Antidepressants, Treatment effectiveness |
| Abstract: | Telomeres are DNA-protein complexes that cap linear DNA strands, protecting DNA from damage. When telomeres critically shorten, cells become susceptible to senescence and apoptosis. Telomerase, a cellular ribonucleoprotein enzyme, rebuilds the length of telomeres and promotes cellular viability. Leukocyte telomeres are reportedly shortened in major depression, but telomerase activity in depression has not been previously reported. Further, there are no published reports of the effects of antidepressants on telomerase activity or on the relationship between telomerase activity and antidepressant response. Peripheral blood mononuclear cell (PBMC) telomerase activity was assessed in 20 medication-free depressed individuals and 18 controls. In total, 16 of the depressed individuals were then treated with sertraline in an open-label manner for 8 weeks, and PBMC telomerase activity was reassessed in 15 of these individuals after treatment. Pre- and post-treatment symptom severity was rated with the Hamilton Depression Rating Scale. All analyses were corrected for age and sex. Pre-treatment telomerase activity was significantly elevated in the depressed individuals compared with the controls (P=0.007) and was directly correlated with depression ratings (P<0.05) across all subjects. In the depressed group, individuals with relatively lower pre-treatment telomerase activity and with relatively greater increase in telomerase activity during treatment, showed superior antidepressant responses (P<0.05 and P<0.005, respectively). This is the first report characterizing telomerase activity in depressed individuals. PBMC telomerase activity might reflect a novel aspect of depressive pathophysiology and might represent a novel biomarker of antidepressant responsiveness. [ABSTRACT FROM AUTHOR] |
| Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 70478526 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Resting leukocyte telomerase activity is elevated in major depression and predicts treatment response. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Wolkowitz%2C+O+M%22">Wolkowitz, O M</searchLink><br /><searchLink fieldCode="AR" term="%22Mellon%2C+S+H%22">Mellon, S H</searchLink><br /><searchLink fieldCode="AR" term="%22Epel%2C+E+S%22">Epel, E S</searchLink><br /><searchLink fieldCode="AR" term="%22Lin%2C+J%22">Lin, J</searchLink><br /><searchLink fieldCode="AR" term="%22Reus%2C+V+I%22">Reus, V I</searchLink><br /><searchLink fieldCode="AR" term="%22Rosser%2C+R%22">Rosser, R</searchLink><br /><searchLink fieldCode="AR" term="%22Burke%2C+H%22">Burke, H</searchLink><br /><searchLink fieldCode="AR" term="%22Compagnone%2C+M%22">Compagnone, M</searchLink><br /><searchLink fieldCode="AR" term="%22Nelson%2C+J+C%22">Nelson, J C</searchLink><br /><searchLink fieldCode="AR" term="%22Dhabhar%2C+F+S%22">Dhabhar, F S</searchLink><br /><searchLink fieldCode="AR" term="%22Blackburn%2C+E+H%22">Blackburn, E H</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Molecular+Psychiatry%22">Molecular Psychiatry</searchLink>. Feb2012, Vol. 17 Issue 2, p164-172. 9p. 1 Chart, 4 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Telomerase%22">Telomerase</searchLink><br /><searchLink fieldCode="DE" term="%22Leukocytes%22">Leukocytes</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Telomeres are DNA-protein complexes that cap linear DNA strands, protecting DNA from damage. When telomeres critically shorten, cells become susceptible to senescence and apoptosis. Telomerase, a cellular ribonucleoprotein enzyme, rebuilds the length of telomeres and promotes cellular viability. Leukocyte telomeres are reportedly shortened in major depression, but telomerase activity in depression has not been previously reported. Further, there are no published reports of the effects of antidepressants on telomerase activity or on the relationship between telomerase activity and antidepressant response. Peripheral blood mononuclear cell (PBMC) telomerase activity was assessed in 20 medication-free depressed individuals and 18 controls. In total, 16 of the depressed individuals were then treated with sertraline in an open-label manner for 8 weeks, and PBMC telomerase activity was reassessed in 15 of these individuals after treatment. Pre- and post-treatment symptom severity was rated with the Hamilton Depression Rating Scale. All analyses were corrected for age and sex. Pre-treatment telomerase activity was significantly elevated in the depressed individuals compared with the controls (P=0.007) and was directly correlated with depression ratings (P<0.05) across all subjects. In the depressed group, individuals with relatively lower pre-treatment telomerase activity and with relatively greater increase in telomerase activity during treatment, showed superior antidepressant responses (P<0.05 and P<0.005, respectively). This is the first report characterizing telomerase activity in depressed individuals. PBMC telomerase activity might reflect a novel aspect of depressive pathophysiology and might represent a novel biomarker of antidepressant responsiveness. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/mp.2010.133 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 164 Subjects: – SubjectFull: Telomerase Type: general – SubjectFull: Leukocytes Type: general – SubjectFull: Therapeutics Type: general – SubjectFull: Mental depression Type: general – SubjectFull: Antidepressants Type: general – SubjectFull: Treatment effectiveness Type: general Titles: – TitleFull: Resting leukocyte telomerase activity is elevated in major depression and predicts treatment response. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wolkowitz, O M – PersonEntity: Name: NameFull: Mellon, S H – PersonEntity: Name: NameFull: Epel, E S – PersonEntity: Name: NameFull: Lin, J – PersonEntity: Name: NameFull: Reus, V I – PersonEntity: Name: NameFull: Rosser, R – PersonEntity: Name: NameFull: Burke, H – PersonEntity: Name: NameFull: Compagnone, M – PersonEntity: Name: NameFull: Nelson, J C – PersonEntity: Name: NameFull: Dhabhar, F S – PersonEntity: Name: NameFull: Blackburn, E H IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2012 Type: published Y: 2012 Identifiers: – Type: issn-print Value: 13594184 Numbering: – Type: volume Value: 17 – Type: issue Value: 2 Titles: – TitleFull: Molecular Psychiatry Type: main |
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