Amphetamine induced dopamine release increases anxiety in individuals recovered from anorexia nervosa.
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| Title: | Amphetamine induced dopamine release increases anxiety in individuals recovered from anorexia nervosa. |
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| Authors: | Bailer, Ursula F. (AUTHOR), Narendran, Rajesh (AUTHOR), Frankle, W. Gordon (AUTHOR), Himes, Michael L. (AUTHOR), Duvvuri, Vikas (AUTHOR), Mathis, Chester A. (AUTHOR), Kaye, Walter H. (AUTHOR) |
| Source: | International Journal of Eating Disorders. Mar2012, Vol. 45 Issue 2, p263-271. 9p. 2 Charts, 2 Graphs. |
| Subjects: | Amphetamines, Analysis of variance, Anorexia nervosa, Anxiety, Comparative studies, Dopamine, Research funding, Self-evaluation, Statistical hypothesis testing, T-test (Statistics), Positron emission tomography, Effect sizes (Statistics), Body mass index, Visual analog scale, Continuing education units, Repeated measures design, Pharmacodynamics |
| Abstract: | Objective: Genetic, pharmacologic, and physiological data suggest that individuals with anorexia nervosa (AN) have altered striatal dopamine (DA) function. Method: We used an amphetamine challenge and positron emission tomography [11C]raclopride paradigm to explore DA striatal transmission in 10 recovered (REC) AN compared with 9 control women (CW). Results: REC AN and CW were similar for baseline, postamphetamine [11C]raclopride binding potential (BPND) and change (Δ) in BPND for all regions. In CW, ventral striatum Δ BPND was associated with euphoria ( r = −0.76; p = 0.03), which was not found for REC AN. Instead, REC AN showed a significant relationship between anxiety and Δ BPND in the precommissural dorsal caudate ( r = −0.62, p = 0.05). Discussion: REC AN have a positive association between endogenous DA release and anxiety in the dorsal caudate. This finding could explain why food-related DA release produces anxiety in AN, whereas feeding is pleasurable in healthy participants. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012) [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Objective: Genetic, pharmacologic, and physiological data suggest that individuals with anorexia nervosa (AN) have altered striatal dopamine (DA) function. Method: We used an amphetamine challenge and positron emission tomography [11C]raclopride paradigm to explore DA striatal transmission in 10 recovered (REC) AN compared with 9 control women (CW). Results: REC AN and CW were similar for baseline, postamphetamine [11C]raclopride binding potential (BPND) and change (Δ) in BPND for all regions. In CW, ventral striatum Δ BPND was associated with euphoria ( r = −0.76; p = 0.03), which was not found for REC AN. Instead, REC AN showed a significant relationship between anxiety and Δ BPND in the precommissural dorsal caudate ( r = −0.62, p = 0.05). Discussion: REC AN have a positive association between endogenous DA release and anxiety in the dorsal caudate. This finding could explain why food-related DA release produces anxiety in AN, whereas feeding is pleasurable in healthy participants. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012) [ABSTRACT FROM AUTHOR] |
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| ISSN: | 02763478 |
| DOI: | 10.1002/eat.20937 |
