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Amphetamine induced dopamine release increases anxiety in individuals recovered from anorexia nervosa.

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Title: Amphetamine induced dopamine release increases anxiety in individuals recovered from anorexia nervosa.
Authors: Bailer, Ursula F. (AUTHOR), Narendran, Rajesh (AUTHOR), Frankle, W. Gordon (AUTHOR), Himes, Michael L. (AUTHOR), Duvvuri, Vikas (AUTHOR), Mathis, Chester A. (AUTHOR), Kaye, Walter H. (AUTHOR)
Source: International Journal of Eating Disorders. Mar2012, Vol. 45 Issue 2, p263-271. 9p. 2 Charts, 2 Graphs.
Subjects: Amphetamines, Analysis of variance, Anorexia nervosa, Anxiety, Comparative studies, Dopamine, Research funding, Self-evaluation, Statistical hypothesis testing, T-test (Statistics), Positron emission tomography, Effect sizes (Statistics), Body mass index, Visual analog scale, Continuing education units, Repeated measures design, Pharmacodynamics
Abstract: Objective: Genetic, pharmacologic, and physiological data suggest that individuals with anorexia nervosa (AN) have altered striatal dopamine (DA) function. Method: We used an amphetamine challenge and positron emission tomography [11C]raclopride paradigm to explore DA striatal transmission in 10 recovered (REC) AN compared with 9 control women (CW). Results: REC AN and CW were similar for baseline, postamphetamine [11C]raclopride binding potential (BPND) and change (Δ) in BPND for all regions. In CW, ventral striatum Δ BPND was associated with euphoria ( r = −0.76; p = 0.03), which was not found for REC AN. Instead, REC AN showed a significant relationship between anxiety and Δ BPND in the precommissural dorsal caudate ( r = −0.62, p = 0.05). Discussion: REC AN have a positive association between endogenous DA release and anxiety in the dorsal caudate. This finding could explain why food-related DA release produces anxiety in AN, whereas feeding is pleasurable in healthy participants. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012) [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Eating Disorders is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Amphetamine induced dopamine release increases anxiety in individuals recovered from anorexia nervosa.
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  Data: <searchLink fieldCode="AR" term="%22Bailer%2C+Ursula+F%2E%22">Bailer, Ursula F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Narendran%2C+Rajesh%22">Narendran, Rajesh</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Frankle%2C+W%2E+Gordon%22">Frankle, W. Gordon</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Himes%2C+Michael+L%2E%22">Himes, Michael L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Duvvuri%2C+Vikas%22">Duvvuri, Vikas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mathis%2C+Chester+A%2E%22">Mathis, Chester A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kaye%2C+Walter+H%2E%22">Kaye, Walter H.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Eating+Disorders%22">International Journal of Eating Disorders</searchLink>. Mar2012, Vol. 45 Issue 2, p263-271. 9p. 2 Charts, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Amphetamines%22">Amphetamines</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+variance%22">Analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Anorexia+nervosa%22">Anorexia nervosa</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety%22">Anxiety</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Dopamine%22">Dopamine</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Self-evaluation%22">Self-evaluation</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+hypothesis+testing%22">Statistical hypothesis testing</searchLink><br /><searchLink fieldCode="DE" term="%22T-test+%28Statistics%29%22">T-test (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Positron+emission+tomography%22">Positron emission tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Effect+sizes+%28Statistics%29%22">Effect sizes (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Body+mass+index%22">Body mass index</searchLink><br /><searchLink fieldCode="DE" term="%22Visual+analog+scale%22">Visual analog scale</searchLink><br /><searchLink fieldCode="DE" term="%22Continuing+education+units%22">Continuing education units</searchLink><br /><searchLink fieldCode="DE" term="%22Repeated+measures+design%22">Repeated measures design</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmacodynamics%22">Pharmacodynamics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: Genetic, pharmacologic, and physiological data suggest that individuals with anorexia nervosa (AN) have altered striatal dopamine (DA) function. Method: We used an amphetamine challenge and positron emission tomography [11C]raclopride paradigm to explore DA striatal transmission in 10 recovered (REC) AN compared with 9 control women (CW). Results: REC AN and CW were similar for baseline, postamphetamine [11C]raclopride binding potential (BPND) and change (Δ) in BPND for all regions. In CW, ventral striatum Δ BPND was associated with euphoria ( r = −0.76; p = 0.03), which was not found for REC AN. Instead, REC AN showed a significant relationship between anxiety and Δ BPND in the precommissural dorsal caudate ( r = −0.62, p = 0.05). Discussion: REC AN have a positive association between endogenous DA release and anxiety in the dorsal caudate. This finding could explain why food-related DA release produces anxiety in AN, whereas feeding is pleasurable in healthy participants. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012) [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Eating Disorders is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=71285713
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1002/eat.20937
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 263
    Subjects:
      – SubjectFull: Amphetamines
        Type: general
      – SubjectFull: Analysis of variance
        Type: general
      – SubjectFull: Anorexia nervosa
        Type: general
      – SubjectFull: Anxiety
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Dopamine
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Self-evaluation
        Type: general
      – SubjectFull: Statistical hypothesis testing
        Type: general
      – SubjectFull: T-test (Statistics)
        Type: general
      – SubjectFull: Positron emission tomography
        Type: general
      – SubjectFull: Effect sizes (Statistics)
        Type: general
      – SubjectFull: Body mass index
        Type: general
      – SubjectFull: Visual analog scale
        Type: general
      – SubjectFull: Continuing education units
        Type: general
      – SubjectFull: Repeated measures design
        Type: general
      – SubjectFull: Pharmacodynamics
        Type: general
    Titles:
      – TitleFull: Amphetamine induced dopamine release increases anxiety in individuals recovered from anorexia nervosa.
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              M: 03
              Text: Mar2012
              Type: published
              Y: 2012
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              Value: 45
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            – TitleFull: International Journal of Eating Disorders
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