Intravenous cocaine induced-activity and behavioural sensitization in norepinephrine-, but not dopamine-transporter knockout mice.
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| Title: | Intravenous cocaine induced-activity and behavioural sensitization in norepinephrine-, but not dopamine-transporter knockout mice. |
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| Authors: | Mead, Andy N. (AUTHOR), Rocha, Beatriz A. (AUTHOR), Donovan, David M. (AUTHOR), Katz, Jonathan L. (AUTHOR) |
| Source: | European Journal of Neuroscience. Aug2002, Vol. 16 Issue 3, p514-520. 7p. 1 Chart. |
| Subjects: | Noradrenaline, Cocaine, Dopamine |
| Abstract: | Abstract Previously, it was reported that both norepinephrine transporter (NET) and dopamine transporter (DAT) knockout (KO) mice were sensitive to the reinforcing effects of cocaine. However, assessing the locomotor-stimulant effects of cocaine in these subjects has proven difficult due to significant differences in their baseline activity compared to wild-type controls. The present studies were designed to clarify the role of NET and DAT in the stimulant effects of acute and repeated cocaine utilizing these knockout mice, and thereby assess the role of these substrates in the locomotor stimulant effects of cocaine. Mice were habituated to the test environment for sufficient time to ensure equal baselines at the time of cocaine administration. Mice then received cocaine (3–25 mg/kg) intravenously according to a within-session cumulative dose–response design. Cocaine dosing was repeated at 48-h intervals for four sessions to assess behavioural sensitization. NET-KO mice exhibited a reduced response to acute cocaine administration compared to wild-type (WT) controls. However, comparable sensitization developed in NET-KO and WT mice. The DAT-KO and DAT-heterozygote (HT) mice displayed no locomotor activation following either acute or repeated cocaine administration. These data suggest a role for the NET in the acute response to cocaine, but no involvement in sensitization to cocaine. In contrast, DAT appears to be necessary for both the acute locomotor response to cocaine and the subsequent development of sensitization. In addition to existing data concerning the reinforcing effects of cocaine in DAT-KO mice, these data suggest a dissociation between the reinforcing and locomotor stimulant effects of cocaine. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 7216050 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Intravenous cocaine induced-activity and behavioural sensitization in norepinephrine-, but not dopamine-transporter knockout mice. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Mead%2C+Andy+N%2E%22">Mead, Andy N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rocha%2C+Beatriz+A%2E%22">Rocha, Beatriz A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Donovan%2C+David+M%2E%22">Donovan, David M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Katz%2C+Jonathan+L%2E%22">Katz, Jonathan L.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Aug2002, Vol. 16 Issue 3, p514-520. 7p. 1 Chart. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Noradrenaline%22">Noradrenaline</searchLink><br /><searchLink fieldCode="DE" term="%22Cocaine%22">Cocaine</searchLink><br /><searchLink fieldCode="DE" term="%22Dopamine%22">Dopamine</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract Previously, it was reported that both norepinephrine transporter (NET) and dopamine transporter (DAT) knockout (KO) mice were sensitive to the reinforcing effects of cocaine. However, assessing the locomotor-stimulant effects of cocaine in these subjects has proven difficult due to significant differences in their baseline activity compared to wild-type controls. The present studies were designed to clarify the role of NET and DAT in the stimulant effects of acute and repeated cocaine utilizing these knockout mice, and thereby assess the role of these substrates in the locomotor stimulant effects of cocaine. Mice were habituated to the test environment for sufficient time to ensure equal baselines at the time of cocaine administration. Mice then received cocaine (3–25 mg/kg) intravenously according to a within-session cumulative dose–response design. Cocaine dosing was repeated at 48-h intervals for four sessions to assess behavioural sensitization. NET-KO mice exhibited a reduced response to acute cocaine administration compared to wild-type (WT) controls. However, comparable sensitization developed in NET-KO and WT mice. The DAT-KO and DAT-heterozygote (HT) mice displayed no locomotor activation following either acute or repeated cocaine administration. These data suggest a role for the NET in the acute response to cocaine, but no involvement in sensitization to cocaine. In contrast, DAT appears to be necessary for both the acute locomotor response to cocaine and the subsequent development of sensitization. In addition to existing data concerning the reinforcing effects of cocaine in DAT-KO mice, these data suggest a dissociation between the reinforcing and locomotor stimulant effects of cocaine. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=7216050 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1046/j.1460-9568.2002.02104.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 514 Subjects: – SubjectFull: Noradrenaline Type: general – SubjectFull: Cocaine Type: general – SubjectFull: Dopamine Type: general Titles: – TitleFull: Intravenous cocaine induced-activity and behavioural sensitization in norepinephrine-, but not dopamine-transporter knockout mice. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Mead, Andy N. – PersonEntity: Name: NameFull: Rocha, Beatriz A. – PersonEntity: Name: NameFull: Donovan, David M. – PersonEntity: Name: NameFull: Katz, Jonathan L. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2002 Type: published Y: 2002 Identifiers: – Type: issn-print Value: 0953816X Numbering: – Type: volume Value: 16 – Type: issue Value: 3 Titles: – TitleFull: European Journal of Neuroscience Type: main |
| ResultId | 1 |
