The Neural Underpinings of Simultanagnosia: Disconnecting the Visuospatial Attention Network.
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| Title: | The Neural Underpinings of Simultanagnosia: Disconnecting the Visuospatial Attention Network. |
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| Authors: | Chechlacz, Magdalena, Rotshtein, Pia, Hansen, Peter C., Riddoch, Jane M., Deb, Shoumitro, Humphreys, Glyn W. |
| Source: | Journal of Cognitive Neuroscience. Apr2012, Vol. 24 Issue 4, p718-735. 18p. 3 Color Photographs, 4 Charts, 2 Graphs. |
| Subjects: | Neurological disorders, Rare diseases, Cognition disorders, Biological neural networks, Cognitive neuroscience, Neuropsychology |
| Abstract: | Because of our limited processing capacity, different elements of the visual scene compete for the allocation of processing resources. One of the most striking deficits in visual selection is simultanagnosia, a rare neuropsychological condition characterized by impaired spatial awareness of more than one object at time. To decompose the neuroanatomical substrates of the syndrome and to gain insights into the structural and functional organization of visuospatial attention, we performed a systematic evaluation of lesion patterns in a group of simultanagnosic patients compared with patients with either (i) unilateral visuospatial deficits (neglect and/or extinction) or (ii) bilateral posterior lesions without visuospatial deficits, using overlap/subtraction analyses, estimation of lesion volume, and a lesion laterality index. We next used voxel-based morphometry to assess the link between different visuospatial deficits and gray matter and white matter (WM) damage. Lesion overlap/subtraction analyses, lesion laterality index, and voxel-based morphometry measures converged to indicate that bilateral parieto-occipital WM disconnections are both distinctive and necessary to create symptoms associated with simultanagnosia. We also found that bilateral gray matter damage within the middle frontal area (BA 46), cuneus, calacarine, and parieto-occipital fissure as well as right hemisphere parietal lesions within intraparietal and postcentral gyri were associated with simultanagnosia. Further analysis of the WM based on tractography revealed associations with bilateral damage to major pathways within the visuospatial attention network, including the superior longitudinal fasciculus, the inferior fronto-occipital fasciculus, and the inferior longitudinal fasciculus. We conclude that damage to the parieto-occipital regions and the intraparietal sulcus, together, with bilateral WM disconnections within the visuosptial attention network, contribute to poor visual processing of multiple objects and the loss of processing speed characteristic of simultanagnosia. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Cognitive Neuroscience is the property of MIT Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 73030727 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The Neural Underpinings of Simultanagnosia: Disconnecting the Visuospatial Attention Network. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Chechlacz%2C+Magdalena%22">Chechlacz, Magdalena</searchLink><br /><searchLink fieldCode="AR" term="%22Rotshtein%2C+Pia%22">Rotshtein, Pia</searchLink><br /><searchLink fieldCode="AR" term="%22Hansen%2C+Peter+C%2E%22">Hansen, Peter C.</searchLink><br /><searchLink fieldCode="AR" term="%22Riddoch%2C+Jane+M%2E%22">Riddoch, Jane M.</searchLink><br /><searchLink fieldCode="AR" term="%22Deb%2C+Shoumitro%22">Deb, Shoumitro</searchLink><br /><searchLink fieldCode="AR" term="%22Humphreys%2C+Glyn+W%2E%22">Humphreys, Glyn W.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Cognitive+Neuroscience%22">Journal of Cognitive Neuroscience</searchLink>. Apr2012, Vol. 24 Issue 4, p718-735. 18p. 3 Color Photographs, 4 Charts, 2 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Neurological+disorders%22">Neurological disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Rare+diseases%22">Rare diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition+disorders%22">Cognition disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Biological+neural+networks%22">Biological neural networks</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+neuroscience%22">Cognitive neuroscience</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychology%22">Neuropsychology</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Because of our limited processing capacity, different elements of the visual scene compete for the allocation of processing resources. One of the most striking deficits in visual selection is simultanagnosia, a rare neuropsychological condition characterized by impaired spatial awareness of more than one object at time. To decompose the neuroanatomical substrates of the syndrome and to gain insights into the structural and functional organization of visuospatial attention, we performed a systematic evaluation of lesion patterns in a group of simultanagnosic patients compared with patients with either (i) unilateral visuospatial deficits (neglect and/or extinction) or (ii) bilateral posterior lesions without visuospatial deficits, using overlap/subtraction analyses, estimation of lesion volume, and a lesion laterality index. We next used voxel-based morphometry to assess the link between different visuospatial deficits and gray matter and white matter (WM) damage. Lesion overlap/subtraction analyses, lesion laterality index, and voxel-based morphometry measures converged to indicate that bilateral parieto-occipital WM disconnections are both distinctive and necessary to create symptoms associated with simultanagnosia. We also found that bilateral gray matter damage within the middle frontal area (BA 46), cuneus, calacarine, and parieto-occipital fissure as well as right hemisphere parietal lesions within intraparietal and postcentral gyri were associated with simultanagnosia. Further analysis of the WM based on tractography revealed associations with bilateral damage to major pathways within the visuospatial attention network, including the superior longitudinal fasciculus, the inferior fronto-occipital fasciculus, and the inferior longitudinal fasciculus. We conclude that damage to the parieto-occipital regions and the intraparietal sulcus, together, with bilateral WM disconnections within the visuosptial attention network, contribute to poor visual processing of multiple objects and the loss of processing speed characteristic of simultanagnosia. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Cognitive Neuroscience is the property of MIT Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1162/jocn_a_00159 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 18 StartPage: 718 Subjects: – SubjectFull: Neurological disorders Type: general – SubjectFull: Rare diseases Type: general – SubjectFull: Cognition disorders Type: general – SubjectFull: Biological neural networks Type: general – SubjectFull: Cognitive neuroscience Type: general – SubjectFull: Neuropsychology Type: general Titles: – TitleFull: The Neural Underpinings of Simultanagnosia: Disconnecting the Visuospatial Attention Network. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chechlacz, Magdalena – PersonEntity: Name: NameFull: Rotshtein, Pia – PersonEntity: Name: NameFull: Hansen, Peter C. – PersonEntity: Name: NameFull: Riddoch, Jane M. – PersonEntity: Name: NameFull: Deb, Shoumitro – PersonEntity: Name: NameFull: Humphreys, Glyn W. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2012 Type: published Y: 2012 Identifiers: – Type: issn-print Value: 0898929X Numbering: – Type: volume Value: 24 – Type: issue Value: 4 Titles: – TitleFull: Journal of Cognitive Neuroscience Type: main |
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