Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism.
Saved in:
| Title: | Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism. |
|---|---|
| Authors: | Villafuerte, S, Heitzeg, M M, Foley, S, Wendy Yau, W-Y, Majczenko, K, Zubieta, J-K, Zucker, R A, Burmeister, M |
| Source: | Molecular Psychiatry. May2012, Vol. 17 Issue 5, p511-519. 9p. 1 Diagram, 3 Charts. |
| Subjects: | People with alcoholism, Alcoholism, Substance abuse, Alcohol drinking, Controlled drinking |
| Abstract: | Genetic factors, externalizing personality traits such as impulsivity, and brain processing of salient stimuli all can affect individual risk for alcoholism. One of very few confirmed genetic association findings differentiating alcoholics from non-alcoholics is with variants in the inhibitory γ-amino butyric acid α2 receptor subunit (GABRA2) gene. Here we report the association of two of these GABRA2 variants with measures of alcohol symptoms, impulsivity and with insula cortex activation during anticipation of reward or loss using functional magnetic resonance imaging (fMRI). In a sample of 173 families (449 subjects), 129 of whom had at least one member diagnosed with alcohol dependence or abuse, carriers for the G allele in two single-nucleotide polymorphisms (SNPs) and haplotypes were more likely to have alcohol dependence symptoms (rs279858, P=0.01; rs279826, P=0.05; haplotype, P=0.02) and higher NEO Personality Inventory-Revised (NEO-PI-R) Impulsiveness scores (rs279858, P=0.016; rs279826, P=0.012; haplotype, P=0.032) with a stronger effect in women (rs279858, P=0.011; rs279826, P=0.002; haplotype, P=0.006), all P-values are corrected for family history and age. A subset of offspring from these families (n=44, 20 females), genotyped for GABRA2, participated in an fMRI study using a monetary incentive delay task. Increased insula activation during reward (r2=0.4; P=0.026) and loss (r2=0.38; P=0.039) anticipation was correlated with NEO-PI-R Impulsiveness and further associated with the GG genotype for both SNPs (P's<0.04). Our results suggest that GABRA2 genetic variation is associated with Impulsiveness through variation of insula activity responses, here evidenced during anticipatory responses. [ABSTRACT FROM AUTHOR] |
| Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 74463086 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Villafuerte%2C+S%22">Villafuerte, S</searchLink><br /><searchLink fieldCode="AR" term="%22Heitzeg%2C+M+M%22">Heitzeg, M M</searchLink><br /><searchLink fieldCode="AR" term="%22Foley%2C+S%22">Foley, S</searchLink><br /><searchLink fieldCode="AR" term="%22Wendy+Yau%2C+W-Y%22">Wendy Yau, W-Y</searchLink><br /><searchLink fieldCode="AR" term="%22Majczenko%2C+K%22">Majczenko, K</searchLink><br /><searchLink fieldCode="AR" term="%22Zubieta%2C+J-K%22">Zubieta, J-K</searchLink><br /><searchLink fieldCode="AR" term="%22Zucker%2C+R+A%22">Zucker, R A</searchLink><br /><searchLink fieldCode="AR" term="%22Burmeister%2C+M%22">Burmeister, M</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Molecular+Psychiatry%22">Molecular Psychiatry</searchLink>. May2012, Vol. 17 Issue 5, p511-519. 9p. 1 Diagram, 3 Charts. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22People+with+alcoholism%22">People with alcoholism</searchLink><br /><searchLink fieldCode="DE" term="%22Alcoholism%22">Alcoholism</searchLink><br /><searchLink fieldCode="DE" term="%22Substance+abuse%22">Substance abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Alcohol+drinking%22">Alcohol drinking</searchLink><br /><searchLink fieldCode="DE" term="%22Controlled+drinking%22">Controlled drinking</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Genetic factors, externalizing personality traits such as impulsivity, and brain processing of salient stimuli all can affect individual risk for alcoholism. One of very few confirmed genetic association findings differentiating alcoholics from non-alcoholics is with variants in the inhibitory γ-amino butyric acid α2 receptor subunit (GABRA2) gene. Here we report the association of two of these GABRA2 variants with measures of alcohol symptoms, impulsivity and with insula cortex activation during anticipation of reward or loss using functional magnetic resonance imaging (fMRI). In a sample of 173 families (449 subjects), 129 of whom had at least one member diagnosed with alcohol dependence or abuse, carriers for the G allele in two single-nucleotide polymorphisms (SNPs) and haplotypes were more likely to have alcohol dependence symptoms (rs279858, P=0.01; rs279826, P=0.05; haplotype, P=0.02) and higher NEO Personality Inventory-Revised (NEO-PI-R) Impulsiveness scores (rs279858, P=0.016; rs279826, P=0.012; haplotype, P=0.032) with a stronger effect in women (rs279858, P=0.011; rs279826, P=0.002; haplotype, P=0.006), all P-values are corrected for family history and age. A subset of offspring from these families (n=44, 20 females), genotyped for GABRA2, participated in an fMRI study using a monetary incentive delay task. Increased insula activation during reward (r2=0.4; P=0.026) and loss (r2=0.38; P=0.039) anticipation was correlated with NEO-PI-R Impulsiveness and further associated with the GG genotype for both SNPs (P's<0.04). Our results suggest that GABRA2 genetic variation is associated with Impulsiveness through variation of insula activity responses, here evidenced during anticipatory responses. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=74463086 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/mp.2011.33 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 511 Subjects: – SubjectFull: People with alcoholism Type: general – SubjectFull: Alcoholism Type: general – SubjectFull: Substance abuse Type: general – SubjectFull: Alcohol drinking Type: general – SubjectFull: Controlled drinking Type: general Titles: – TitleFull: Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Villafuerte, S – PersonEntity: Name: NameFull: Heitzeg, M M – PersonEntity: Name: NameFull: Foley, S – PersonEntity: Name: NameFull: Wendy Yau, W-Y – PersonEntity: Name: NameFull: Majczenko, K – PersonEntity: Name: NameFull: Zubieta, J-K – PersonEntity: Name: NameFull: Zucker, R A – PersonEntity: Name: NameFull: Burmeister, M IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2012 Type: published Y: 2012 Identifiers: – Type: issn-print Value: 13594184 Numbering: – Type: volume Value: 17 – Type: issue Value: 5 Titles: – TitleFull: Molecular Psychiatry Type: main |
| ResultId | 1 |
