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Effects of training at mild exercise intensities on quadriceps muscle energy metabolism in patients with chronic obstructive pulmonary disease.

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Title: Effects of training at mild exercise intensities on quadriceps muscle energy metabolism in patients with chronic obstructive pulmonary disease.
Authors: Guzun, R., Aguilaniu, B., Wuyam, B., Mezin, P., Koechlin-Ramonatxo, C., Auffray, C., Saks, V., Pison, C.
Source: Acta Physiologica. Jun2012, Vol. 205 Issue 2, p236-246. 11p. 3 Charts, 2 Graphs.
Subjects: Obstructive lung diseases, Energy metabolism, Exercise, Creatine kinase, Skeletal muscle
Abstract: Aim: To study the effects of physical training at mild intensities on skeletal muscle energy metabolism in eight patients with chronic obstructive pulmonary disease (COPD) and eight paired healthy sedentary subjects. Methods: Energy metabolism of patients and controls vastus lateralis muscle was studied before and after 3 months of cycling training at mild exercises intensities. Results: The total amount of work accomplished was about 4059 ± 336 kJ in patients with COPD and 7531 ± 1693 kJ in control subjects. This work corresponds to a mechanical power set at 65.2 ± 7.5% of the maximum power for patients with COPD and 52 ± 3.3% of the maximum power in control group. Despite this low level of exercise intensities, we observed an improvement in mitochondrial oxidative phosphorylation through the creatine kinase system revealed by the increased apparent Km for ADP (from 105.5 ± 16.1 to 176.9 ± 26.5 μ m, P < 0.05 in the COPD group and from 126.9 ± 16.8 to 177.7 ± 17.0, P > 0.05 in the control group). Meanwhile, maximal mechanical and metabolic power increased significantly from 83.1 ± 7.1 to 91.3 ± 7.4 Watts ( P < 0.05) and from 16 ± 0.8 to 18.7 ± 0.98 mL O2 kg−1 min−1 ( P < 0.05) only in the COPD group. Conclusion: This study shows that physical training at mild intensity is able to induce comparable changes in skeletal muscles oxidative energy metabolism in patients with COPD and sedentary healthy subjects, but different changes of maximal mechanical and metabolic power. [ABSTRACT FROM AUTHOR]
Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Effects of training at mild exercise intensities on quadriceps muscle energy metabolism in patients with chronic obstructive pulmonary disease.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Guzun%2C+R%2E%22&quot;&gt;Guzun, R.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Aguilaniu%2C+B%2E%22&quot;&gt;Aguilaniu, B.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wuyam%2C+B%2E%22&quot;&gt;Wuyam, B.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mezin%2C+P%2E%22&quot;&gt;Mezin, P.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Koechlin-Ramonatxo%2C+C%2E%22&quot;&gt;Koechlin-Ramonatxo, C.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Auffray%2C+C%2E%22&quot;&gt;Auffray, C.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Saks%2C+V%2E%22&quot;&gt;Saks, V.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pison%2C+C%2E%22&quot;&gt;Pison, C.&lt;/searchLink&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Acta+Physiologica%22&quot;&gt;Acta Physiologica&lt;/searchLink&gt;. Jun2012, Vol. 205 Issue 2, p236-246. 11p. 3 Charts, 2 Graphs.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Obstructive+lung+diseases%22&quot;&gt;Obstructive lung diseases&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Energy+metabolism%22&quot;&gt;Energy metabolism&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Exercise%22&quot;&gt;Exercise&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Creatine+kinase%22&quot;&gt;Creatine kinase&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Skeletal+muscle%22&quot;&gt;Skeletal muscle&lt;/searchLink&gt;
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  Data: Aim: To study the effects of physical training at mild intensities on skeletal muscle energy metabolism in eight patients with chronic obstructive pulmonary disease (COPD) and eight paired healthy sedentary subjects. Methods: Energy metabolism of patients and controls vastus lateralis muscle was studied before and after 3 months of cycling training at mild exercises intensities. Results: The total amount of work accomplished was about 4059 &#177; 336 kJ in patients with COPD and 7531 &#177; 1693 kJ in control subjects. This work corresponds to a mechanical power set at 65.2 &#177; 7.5% of the maximum power for patients with COPD and 52 &#177; 3.3% of the maximum power in control group. Despite this low level of exercise intensities, we observed an improvement in mitochondrial oxidative phosphorylation through the creatine kinase system revealed by the increased apparent Km for ADP (from 105.5 &#177; 16.1 to 176.9 &#177; 26.5 μ m, P &lt; 0.05 in the COPD group and from 126.9 &#177; 16.8 to 177.7 &#177; 17.0, P &gt; 0.05 in the control group). Meanwhile, maximal mechanical and metabolic power increased significantly from 83.1 &#177; 7.1 to 91.3 &#177; 7.4 Watts ( P &lt; 0.05) and from 16 &#177; 0.8 to 18.7 &#177; 0.98 mL O2 kg−1 min−1 ( P &lt; 0.05) only in the COPD group. Conclusion: This study shows that physical training at mild intensity is able to induce comparable changes in skeletal muscles oxidative energy metabolism in patients with COPD and sedentary healthy subjects, but different changes of maximal mechanical and metabolic power. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1111/j.1748-1716.2011.02388.x
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        Text: English
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      – SubjectFull: Energy metabolism
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      – SubjectFull: Exercise
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      – SubjectFull: Creatine kinase
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      – SubjectFull: Skeletal muscle
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              Text: Jun2012
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