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Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche.

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Title: Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche.
Authors: Lee, Daniel A, Bedont, Joseph L, Pak, Thomas, Wang, Hong, Song, Juan, Miranda-Angulo, Ana, Takiar, Vani, Charubhumi, Vanessa, Balordi, Francesca, Takebayashi, Hirohide, Aja, Susan, Ford, Eric, Fishell, Gordon, Blackshaw, Seth
Source: Nature Neuroscience. May2012, Vol. 15 Issue 5, p700-702. 3p.
Subjects: Hypothalamic hormones, Developmental neurobiology, Neurons, Cells, Hypothalamus
Abstract: Adult hypothalamic neurogenesis has recently been reported, but the cell of origin and the function of these newborn neurons are unknown. Using genetic fate mapping, we found that median eminence tanycytes generate newborn neurons. Blocking this neurogenesis altered the weight and metabolic activity of adult mice. These findings reveal a previously unreported neurogenic niche in the mammalian hypothalamus with important implications for metabolism. [ABSTRACT FROM AUTHOR]
Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. May2012, Vol. 15 Issue 5, p700-702. 3p.
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  Data: Adult hypothalamic neurogenesis has recently been reported, but the cell of origin and the function of these newborn neurons are unknown. Using genetic fate mapping, we found that median eminence tanycytes generate newborn neurons. Blocking this neurogenesis altered the weight and metabolic activity of adult mice. These findings reveal a previously unreported neurogenic niche in the mammalian hypothalamus with important implications for metabolism. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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