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Sleep deprivation modulates brain mRNAs encoding genes of glycogen metabolism.

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Title: Sleep deprivation modulates brain mRNAs encoding genes of glycogen metabolism.
Authors: Petit, Jean‐Marie (AUTHOR), Tobler, Irene (AUTHOR), Allaman, Igor (AUTHOR), Borbély, Alexander A. (AUTHOR), Magistretti, Pierre J. (AUTHOR)
Source: European Journal of Neuroscience. Sep2002, Vol. 16 Issue 6, p1163-1167. 5p. 1 Chart.
Subjects: Sleep deprivation, Messenger RNA, Glycogen
Abstract: Abstract Replenishment of brain glycogen stores depleted during waking has been suggested to constitute one of the functions of sleep [Benington, J. H. & Heller H. C. (1995) Prog. Neurobiol. , 45 , 347]. We have tested the hypothesis that the level of expression of enzymes involved in glycogen metabolism could undergo variations throughout the sleep-waking or rest-activity cycle, and after 6 h of ‘gentle’ total sleep deprivation in mice. Specifically, we determined the variations in mRNAs coding for protein targeting to glycogen (PTG), glycogen synthase and glycogen phosphorylase, all considered as key regulators of glycogen metabolism. Glycogen synthase and glycogen phosphorylase mRNAs exhibited significant variations throughout the light-dark cycle with a maximum at the middle of the light period and a minimum at the middle of the dark period. Following sleep deprivation, a two-fold increase in PTG mRNA and a decrease of mRNAs encoding glycogen synthase and glycogen phosphorylase were observed. These transcriptional events have functional consequences as the activity of glycogen synthase was increased 2.5-fold indicating a stimulating effect of sleep deprivation on glycogen synthesis. These results indicate that (i) expression of genes related to brain glycogen metabolism exhibit variations throughout the sleep-waking or rest-activity cycle and (ii) given the almost selective localization of glycogen to astrocytes, these cells might participate in the regulation of sleep. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Sleep deprivation modulates brain mRNAs encoding genes of glycogen metabolism.
– Name: Author
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  Data: <searchLink fieldCode="AR" term="%22Petit%2C+Jean‐Marie%22">Petit, Jean‐Marie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tobler%2C+Irene%22">Tobler, Irene</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Allaman%2C+Igor%22">Allaman, Igor</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Borbély%2C+Alexander+A%2E%22">Borbély, Alexander A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Magistretti%2C+Pierre+J%2E%22">Magistretti, Pierre J.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Sep2002, Vol. 16 Issue 6, p1163-1167. 5p. 1 Chart.
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  Data: <searchLink fieldCode="DE" term="%22Sleep+deprivation%22">Sleep deprivation</searchLink><br /><searchLink fieldCode="DE" term="%22Messenger+RNA%22">Messenger RNA</searchLink><br /><searchLink fieldCode="DE" term="%22Glycogen%22">Glycogen</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Abstract Replenishment of brain glycogen stores depleted during waking has been suggested to constitute one of the functions of sleep [Benington, J. H. & Heller H. C. (1995) Prog. Neurobiol. , 45 , 347]. We have tested the hypothesis that the level of expression of enzymes involved in glycogen metabolism could undergo variations throughout the sleep-waking or rest-activity cycle, and after 6 h of ‘gentle’ total sleep deprivation in mice. Specifically, we determined the variations in mRNAs coding for protein targeting to glycogen (PTG), glycogen synthase and glycogen phosphorylase, all considered as key regulators of glycogen metabolism. Glycogen synthase and glycogen phosphorylase mRNAs exhibited significant variations throughout the light-dark cycle with a maximum at the middle of the light period and a minimum at the middle of the dark period. Following sleep deprivation, a two-fold increase in PTG mRNA and a decrease of mRNAs encoding glycogen synthase and glycogen phosphorylase were observed. These transcriptional events have functional consequences as the activity of glycogen synthase was increased 2.5-fold indicating a stimulating effect of sleep deprivation on glycogen synthesis. These results indicate that (i) expression of genes related to brain glycogen metabolism exhibit variations throughout the sleep-waking or rest-activity cycle and (ii) given the almost selective localization of glycogen to astrocytes, these cells might participate in the regulation of sleep. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1046/j.1460-9568.2002.02145.x
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      – Code: eng
        Text: English
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        Type: general
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      – SubjectFull: Glycogen
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              Text: Sep2002
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