Depressive disorder moderates the effect of the FTO gene on body mass index.
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| Title: | Depressive disorder moderates the effect of the FTO gene on body mass index. |
|---|---|
| Authors: | Rivera, M, Cohen-Woods, S, Kapur, K, Breen, G, Ng, M Y, Butler, A W, Craddock, N, Gill, M, Korszun, A, Maier, W, Mors, O, Owen, M J, Preisig, M, Bergmann, S, Tozzi, F, Rice, J, Rietschel, M, Rucker, J, Schosser, A, Aitchison, K J |
| Source: | Molecular Psychiatry. Jun2012, Vol. 17 Issue 6, p604-611. 8p. |
| Subjects: | Mental depression, Obesity, Body mass index, Genetic polymorphisms, Etiology of diseases, Regression analysis |
| Abstract: | There is evidence that obesity-related disorders are increased among people with depression. Variation in the FTO (fat mass and obesity associated) gene has been shown to contribute to common forms of human obesity. This study aimed to investigate the genetic influence of polymorphisms in FTO in relation to body mass index (BMI) in two independent samples of major depressive disorder (MDD) cases and controls. We analysed 88 polymorphisms in the FTO gene in a clinically ascertained sample of 2442 MDD cases and 809 controls (Radiant Study). In all, 8 of the top 10 single-nucleotide polymorphisms (SNPs) showing the strongest associations with BMI were followed-up in a population-based cohort (PsyCoLaus Study) consisting of 1292 depression cases and 1690 controls. Linear regression analyses of the FTO variants and BMI yielded 10 SNPs significantly associated with increased BMI in the depressive group but not the control group in the Radiant sample. The same pattern was found in the PsyCoLaus sample. We found a significant interaction between genotype and affected status in relation to BMI for seven SNPs in Radiant (P<0.0057), with PsyCoLaus giving supportive evidence for five SNPs (P-values between 0.03 and 0.06), which increased in significance when the data were combined in a meta-analysis. This is the first study investigating FTO and BMI within the context of MDD, and the results indicate that having a history of depression moderates the effect of FTO on BMI. This finding suggests that FTO is involved in the mechanism underlying the association between mood disorders and obesity. [ABSTRACT FROM AUTHOR] |
| Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 75394605 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/mp.2011.45 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 604 Subjects: – SubjectFull: Mental depression Type: general – SubjectFull: Obesity Type: general – SubjectFull: Body mass index Type: general – SubjectFull: Genetic polymorphisms Type: general – SubjectFull: Etiology of diseases Type: general – SubjectFull: Regression analysis Type: general Titles: – TitleFull: Depressive disorder moderates the effect of the FTO gene on body mass index. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rivera, M – PersonEntity: Name: NameFull: Cohen-Woods, S – PersonEntity: Name: NameFull: Kapur, K – PersonEntity: Name: NameFull: Breen, G – PersonEntity: Name: NameFull: Ng, M Y – PersonEntity: Name: NameFull: Butler, A W – PersonEntity: Name: NameFull: Craddock, N – PersonEntity: Name: NameFull: Gill, M – PersonEntity: Name: NameFull: Korszun, A – PersonEntity: Name: NameFull: Maier, W – PersonEntity: Name: NameFull: Mors, O – PersonEntity: Name: NameFull: Owen, M J – PersonEntity: Name: NameFull: Preisig, M – PersonEntity: Name: NameFull: Bergmann, S – PersonEntity: Name: NameFull: Tozzi, F – PersonEntity: Name: NameFull: Rice, J – PersonEntity: Name: NameFull: Rietschel, M – PersonEntity: Name: NameFull: Rucker, J – PersonEntity: Name: NameFull: Schosser, A – PersonEntity: Name: NameFull: Aitchison, K J IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2012 Type: published Y: 2012 Identifiers: – Type: issn-print Value: 13594184 Numbering: – Type: volume Value: 17 – Type: issue Value: 6 Titles: – TitleFull: Molecular Psychiatry Type: main |
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