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Acute Study on The Efficacy and Safety of an Auditory Brainstem Prosthesis.

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Title: Acute Study on The Efficacy and Safety of an Auditory Brainstem Prosthesis.
Authors: LIU, XUGUANG, MCPHEE, GREG, SELDON, H. LEE, CLARK, GRAEME M.
Source: Acta Oto-Laryngologica. Jan98, Vol. 118 Issue 1, p37-45. 9p.
Subjects: Brain stem, Cochlear implants, Ear prostheses, Surgery
Abstract: Patients with profound binaural sensorineural hearing loss can be treated with cochlear implantation. In recent years, patients who have lost the integrity of the auditory nerve between the spiral ganglion and the cochlear nucleus in the brainstem, and cannot benefit from a cochlear implant, have reported auditory sensations following direct stimulation of the cochlear nucleus with an auditory brainstem prosthesis. To examine the safety and efficacy of such a prosthesis, the cochlear nuclei of guinea-pigs were acutely implanted and stimulated unilaterally with bipolar surface electrodes using the parameters of human implants. The activation of the central auditory pathway by the prosthesis was demonstrated using the 2-deoxyglucose technique. There was broad 2-deoxyglucose labelling in the ipsilateral cochlear nucleus and bilaterally in the inferior colliculi, indicating unusual stimulation of the ipsilateral ascending pathway. Histological examination was performed on all cochlear nuclei. The volumes of cochlear nuclei and the neuron sizes and density in the cochlear nuclei were analysed with three-dimensional reconstruction techniques, and comparisons were made between the stimulated and unstimulated sides. No histological difference, either by direct visual observation or by statistical comparisons, was observed between the stimulated cochlear nuclei and the control sides. These results suggest that in the acute case the auditory brainstem prostheses can safely and effectively activate the auditory pathway in guinea-pigs. [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Acute Study on The Efficacy and Safety of an Auditory Brainstem Prosthesis.
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  Data: <searchLink fieldCode="AR" term="%22LIU%2C+XUGUANG%22">LIU, XUGUANG</searchLink><br /><searchLink fieldCode="AR" term="%22MCPHEE%2C+GREG%22">MCPHEE, GREG</searchLink><br /><searchLink fieldCode="AR" term="%22SELDON%2C+H%2E+LEE%22">SELDON, H. LEE</searchLink><br /><searchLink fieldCode="AR" term="%22CLARK%2C+GRAEME+M%2E%22">CLARK, GRAEME M.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. Jan98, Vol. 118 Issue 1, p37-45. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Brain+stem%22">Brain stem</searchLink><br /><searchLink fieldCode="DE" term="%22Cochlear+implants%22">Cochlear implants</searchLink><br /><searchLink fieldCode="DE" term="%22Ear+prostheses%22">Ear prostheses</searchLink><br /><searchLink fieldCode="DE" term="%22Surgery%22">Surgery</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Patients with profound binaural sensorineural hearing loss can be treated with cochlear implantation. In recent years, patients who have lost the integrity of the auditory nerve between the spiral ganglion and the cochlear nucleus in the brainstem, and cannot benefit from a cochlear implant, have reported auditory sensations following direct stimulation of the cochlear nucleus with an auditory brainstem prosthesis. To examine the safety and efficacy of such a prosthesis, the cochlear nuclei of guinea-pigs were acutely implanted and stimulated unilaterally with bipolar surface electrodes using the parameters of human implants. The activation of the central auditory pathway by the prosthesis was demonstrated using the 2-deoxyglucose technique. There was broad 2-deoxyglucose labelling in the ipsilateral cochlear nucleus and bilaterally in the inferior colliculi, indicating unusual stimulation of the ipsilateral ascending pathway. Histological examination was performed on all cochlear nuclei. The volumes of cochlear nuclei and the neuron sizes and density in the cochlear nuclei were analysed with three-dimensional reconstruction techniques, and comparisons were made between the stimulated and unstimulated sides. No histological difference, either by direct visual observation or by statistical comparisons, was observed between the stimulated cochlear nuclei and the control sides. These results suggest that in the acute case the auditory brainstem prostheses can safely and effectively activate the auditory pathway in guinea-pigs. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/00016489850155107
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      – Code: eng
        Text: English
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    Subjects:
      – SubjectFull: Brain stem
        Type: general
      – SubjectFull: Cochlear implants
        Type: general
      – SubjectFull: Ear prostheses
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      – SubjectFull: Surgery
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            NameFull: SELDON, H. LEE
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            NameFull: CLARK, GRAEME M.
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            – D: 01
              M: 01
              Text: Jan98
              Type: published
              Y: 1998
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