View in EDS PDF Full Text

Infralimbic and dorsal raphé microinjection of the 5-HT receptor agonist CP-93,129: attenuation of aggressive behavior in CFW male mice.

Saved in:
Bibliographic Details
Title: Infralimbic and dorsal raphé microinjection of the 5-HT receptor agonist CP-93,129: attenuation of aggressive behavior in CFW male mice.
Authors: Faccidomo, S., Quadros, I., Takahashi, A., Fish, E., Miczek, K.
Source: Psychopharmacology. Jul2012, Vol. 222 Issue 1, p117-128. 12p. 1 Diagram, 2 Charts, 2 Graphs.
Subjects: Brain disease treatment, Animal aggression, Laboratory mice, Serotonin receptors, Serotoninergic mechanisms, Prefrontal cortex, Microinjections, Interpersonal relations
Abstract: Rationale: Aggressive behavior and impaired impulse control have been associated with dysregulations in the serotonergic system and with impaired functioning of the prefrontal cortex. 5-HT receptors have been shown to specifically modulate several types of offensive aggression. Objective: This study aims to characterize the relative importance of two populations of 5-HT receptors in the dorsal raphé nucleus (DRN) and infralimbic cortex (ILC) in the modulation of aggressive behavior. Methods: Male CFW mice were conditioned on a fixed-ratio 5 schedule of reinforcement to self-administer a 6% ( w/ v) alcohol solution. Mice repeatedly engaged in 5-min aggressive confrontations until aggressive behavior stabilized. Next, a cannula was implanted into either the DRN or the ILC. After recovery, mice were tested for aggression after self-administration of either 1.0 g/kg alcohol or water prior to a microinjection of the 5-HT agonist, CP-93,129 (0-1.0 μg/infusion). Results: In both the DRN and ILC, CP-93,129 reduced aggressive behaviors after both water and alcohol self-administration. Intra-raphé CP-93,129 dose-dependently reduced both aggressive and locomotor behaviors. However, the anti-aggressive effects of intra-cortical CP-93,129 were behaviorally specific. Conclusions: These findings highlight the importance of the serotonergic system in the modulation of aggression and suggest that the behaviorally specific effects of 5-HT receptor agonists are regionally selective. 5-HT receptors in a medial subregion of the prefrontal cortex, the ILC, appear to be critically involved in the attenuation of species-typical levels of aggression. [ABSTRACT FROM AUTHOR]
Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 76350402
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Infralimbic and dorsal raphé microinjection of the 5-HT receptor agonist CP-93,129: attenuation of aggressive behavior in CFW male mice.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Faccidomo%2C+S%2E%22">Faccidomo, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Quadros%2C+I%2E%22">Quadros, I.</searchLink><br /><searchLink fieldCode="AR" term="%22Takahashi%2C+A%2E%22">Takahashi, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Fish%2C+E%2E%22">Fish, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Miczek%2C+K%2E%22">Miczek, K.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Jul2012, Vol. 222 Issue 1, p117-128. 12p. 1 Diagram, 2 Charts, 2 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Brain+disease+treatment%22">Brain disease treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+aggression%22">Animal aggression</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+mice%22">Laboratory mice</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin+receptors%22">Serotonin receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Serotoninergic+mechanisms%22">Serotoninergic mechanisms</searchLink><br /><searchLink fieldCode="DE" term="%22Prefrontal+cortex%22">Prefrontal cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Microinjections%22">Microinjections</searchLink><br /><searchLink fieldCode="DE" term="%22Interpersonal+relations%22">Interpersonal relations</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Rationale: Aggressive behavior and impaired impulse control have been associated with dysregulations in the serotonergic system and with impaired functioning of the prefrontal cortex. 5-HT receptors have been shown to specifically modulate several types of offensive aggression. Objective: This study aims to characterize the relative importance of two populations of 5-HT receptors in the dorsal raphé nucleus (DRN) and infralimbic cortex (ILC) in the modulation of aggressive behavior. Methods: Male CFW mice were conditioned on a fixed-ratio 5 schedule of reinforcement to self-administer a 6% ( w/ v) alcohol solution. Mice repeatedly engaged in 5-min aggressive confrontations until aggressive behavior stabilized. Next, a cannula was implanted into either the DRN or the ILC. After recovery, mice were tested for aggression after self-administration of either 1.0 g/kg alcohol or water prior to a microinjection of the 5-HT agonist, CP-93,129 (0-1.0 μg/infusion). Results: In both the DRN and ILC, CP-93,129 reduced aggressive behaviors after both water and alcohol self-administration. Intra-raphé CP-93,129 dose-dependently reduced both aggressive and locomotor behaviors. However, the anti-aggressive effects of intra-cortical CP-93,129 were behaviorally specific. Conclusions: These findings highlight the importance of the serotonergic system in the modulation of aggression and suggest that the behaviorally specific effects of 5-HT receptor agonists are regionally selective. 5-HT receptors in a medial subregion of the prefrontal cortex, the ILC, appear to be critically involved in the attenuation of species-typical levels of aggression. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=76350402
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00213-011-2629-1
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 117
    Subjects:
      – SubjectFull: Brain disease treatment
        Type: general
      – SubjectFull: Animal aggression
        Type: general
      – SubjectFull: Laboratory mice
        Type: general
      – SubjectFull: Serotonin receptors
        Type: general
      – SubjectFull: Serotoninergic mechanisms
        Type: general
      – SubjectFull: Prefrontal cortex
        Type: general
      – SubjectFull: Microinjections
        Type: general
      – SubjectFull: Interpersonal relations
        Type: general
    Titles:
      – TitleFull: Infralimbic and dorsal raphé microinjection of the 5-HT receptor agonist CP-93,129: attenuation of aggressive behavior in CFW male mice.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Faccidomo, S.
      – PersonEntity:
          Name:
            NameFull: Quadros, I.
      – PersonEntity:
          Name:
            NameFull: Takahashi, A.
      – PersonEntity:
          Name:
            NameFull: Fish, E.
      – PersonEntity:
          Name:
            NameFull: Miczek, K.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 07
              Text: Jul2012
              Type: published
              Y: 2012
          Identifiers:
            – Type: issn-print
              Value: 00333158
          Numbering:
            – Type: volume
              Value: 222
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Psychopharmacology
              Type: main
ResultId 1