Infralimbic and dorsal raphé microinjection of the 5-HT receptor agonist CP-93,129: attenuation of aggressive behavior in CFW male mice.
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| Title: | Infralimbic and dorsal raphé microinjection of the 5-HT receptor agonist CP-93,129: attenuation of aggressive behavior in CFW male mice. |
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| Authors: | Faccidomo, S., Quadros, I., Takahashi, A., Fish, E., Miczek, K. |
| Source: | Psychopharmacology. Jul2012, Vol. 222 Issue 1, p117-128. 12p. 1 Diagram, 2 Charts, 2 Graphs. |
| Subjects: | Brain disease treatment, Animal aggression, Laboratory mice, Serotonin receptors, Serotoninergic mechanisms, Prefrontal cortex, Microinjections, Interpersonal relations |
| Abstract: | Rationale: Aggressive behavior and impaired impulse control have been associated with dysregulations in the serotonergic system and with impaired functioning of the prefrontal cortex. 5-HT receptors have been shown to specifically modulate several types of offensive aggression. Objective: This study aims to characterize the relative importance of two populations of 5-HT receptors in the dorsal raphé nucleus (DRN) and infralimbic cortex (ILC) in the modulation of aggressive behavior. Methods: Male CFW mice were conditioned on a fixed-ratio 5 schedule of reinforcement to self-administer a 6% ( w/ v) alcohol solution. Mice repeatedly engaged in 5-min aggressive confrontations until aggressive behavior stabilized. Next, a cannula was implanted into either the DRN or the ILC. After recovery, mice were tested for aggression after self-administration of either 1.0 g/kg alcohol or water prior to a microinjection of the 5-HT agonist, CP-93,129 (0-1.0 μg/infusion). Results: In both the DRN and ILC, CP-93,129 reduced aggressive behaviors after both water and alcohol self-administration. Intra-raphé CP-93,129 dose-dependently reduced both aggressive and locomotor behaviors. However, the anti-aggressive effects of intra-cortical CP-93,129 were behaviorally specific. Conclusions: These findings highlight the importance of the serotonergic system in the modulation of aggression and suggest that the behaviorally specific effects of 5-HT receptor agonists are regionally selective. 5-HT receptors in a medial subregion of the prefrontal cortex, the ILC, appear to be critically involved in the attenuation of species-typical levels of aggression. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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