View in EDS PDF Full Text

Host-Gut Microbiota Metabolic Interactions.

Saved in:
Bibliographic Details
Title: Host-Gut Microbiota Metabolic Interactions.
Authors: Nicholson, Jeremy K., Holmes, Elaine, Kinross, James, Burcelin, Remy, Gibson, Glenn, Wei Jia, Petterssons, Sven
Source: Science (pre-March 2025). 6/8/2012, Vol. 336 Issue 6086, p1262-1267. 6p.
Subjects: Gut microbiota, Microbial metabolism, Coevolution, Cellular signal transduction, Immune system, Inflammation, Liver physiology, Muscle physiology, Brain physiology, Physiology
Abstract: The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style. The gut microbiota is involved in the regulation of multiple host metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling, and immune-inflammatory axes that physiologically connect the gut, liver, muscle, and brain. A deeper understanding of these axes is a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 76598290
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Host-Gut Microbiota Metabolic Interactions.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Nicholson%2C+Jeremy+K%2E%22">Nicholson, Jeremy K.</searchLink><br /><searchLink fieldCode="AR" term="%22Holmes%2C+Elaine%22">Holmes, Elaine</searchLink><br /><searchLink fieldCode="AR" term="%22Kinross%2C+James%22">Kinross, James</searchLink><br /><searchLink fieldCode="AR" term="%22Burcelin%2C+Remy%22">Burcelin, Remy</searchLink><br /><searchLink fieldCode="AR" term="%22Gibson%2C+Glenn%22">Gibson, Glenn</searchLink><br /><searchLink fieldCode="AR" term="%22Wei+Jia%22">Wei Jia</searchLink><br /><searchLink fieldCode="AR" term="%22Petterssons%2C+Sven%22">Petterssons, Sven</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 6/8/2012, Vol. 336 Issue 6086, p1262-1267. 6p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Gut+microbiota%22">Gut microbiota</searchLink><br /><searchLink fieldCode="DE" term="%22Microbial+metabolism%22">Microbial metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Coevolution%22">Coevolution</searchLink><br /><searchLink fieldCode="DE" term="%22Cellular+signal+transduction%22">Cellular signal transduction</searchLink><br /><searchLink fieldCode="DE" term="%22Immune+system%22">Immune system</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22Liver+physiology%22">Liver physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Muscle+physiology%22">Muscle physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+physiology%22">Brain physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Physiology%22">Physiology</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style. The gut microbiota is involved in the regulation of multiple host metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling, and immune-inflammatory axes that physiologically connect the gut, liver, muscle, and brain. A deeper understanding of these axes is a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=76598290
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1126/science.1223813
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 1262
    Subjects:
      – SubjectFull: Gut microbiota
        Type: general
      – SubjectFull: Microbial metabolism
        Type: general
      – SubjectFull: Coevolution
        Type: general
      – SubjectFull: Cellular signal transduction
        Type: general
      – SubjectFull: Immune system
        Type: general
      – SubjectFull: Inflammation
        Type: general
      – SubjectFull: Liver physiology
        Type: general
      – SubjectFull: Muscle physiology
        Type: general
      – SubjectFull: Brain physiology
        Type: general
      – SubjectFull: Physiology
        Type: general
    Titles:
      – TitleFull: Host-Gut Microbiota Metabolic Interactions.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Nicholson, Jeremy K.
      – PersonEntity:
          Name:
            NameFull: Holmes, Elaine
      – PersonEntity:
          Name:
            NameFull: Kinross, James
      – PersonEntity:
          Name:
            NameFull: Burcelin, Remy
      – PersonEntity:
          Name:
            NameFull: Gibson, Glenn
      – PersonEntity:
          Name:
            NameFull: Wei Jia
      – PersonEntity:
          Name:
            NameFull: Petterssons, Sven
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 08
              M: 06
              Text: 6/8/2012
              Type: published
              Y: 2012
          Identifiers:
            – Type: issn-print
              Value: 00368075
          Numbering:
            – Type: volume
              Value: 336
            – Type: issue
              Value: 6086
          Titles:
            – TitleFull: Science (pre-March 2025)
              Type: main
ResultId 1