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Clinical and genetic outcome determinants of Internet- and group-based cognitive behavior therapy for social anxiety disorder.

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Title: Clinical and genetic outcome determinants of Internet- and group-based cognitive behavior therapy for social anxiety disorder.
Authors: Hedman, E. (AUTHOR), Andersson, E. (AUTHOR), Ljótsson, B. (AUTHOR), Andersson, G. (AUTHOR), Schalling, M. (AUTHOR), Lindefors, N. (AUTHOR), Rück, C. (AUTHOR)
Source: Acta Psychiatrica Scandinavica. Aug2012, Vol. 126 Issue 2, p126-136. 11p. 1 Diagram, 4 Charts.
Subjects: Cognitive therapy, Social anxiety, Anxiety disorders, Randomized controlled trials, Genetic polymorphisms
Abstract: Hedman E, Andersson E, Ljótsson B, Andersson G, Andersson E, Schalling M, Lindefors N, Rück C. Clinical and genetic outcome determinants of Internet- and group-based cognitive behavior therapy for social anxiety disorder (SAD). Objective: No study has investigated clinical or genetic predictors and moderators of Internet-based cognitive behavior therapy (ICBT) compared with cognitive behavioral group therapy for (CBGT) for SAD. Identification of predictors and moderators is essential to the clinician in deciding which treatment to recommend for whom. We aimed to identify clinical and genetic (5-HTTLPR, COMTval158met, and BDNFval66met) predictors and moderators of ICBT and CBGT. Method: We performed three types of analyses on data from a sample comprising participants ( N = 126) who had undergone ICBT or CBGT in a randomized controlled trial. Outcomes were i) end state symptom severity, ii) SAD diagnosis, and iii) clinically significant improvement. Results: The most stable predictors of better treatment response were working full time, having children, less depressive symptoms, higher expectancy of treatment effectiveness, and adhering to treatment. None of the tested gene polymorphisms were associated with treatment outcome. Comorbid general anxiety and depression were moderators meaning that lower levels were associated with a better treatment response in ICBT but not in CBGT. Conclusion: We conclude that demographic factors, symptom burden, adherence, and expectations may play an important role as predictors of treatment outcome. The investigated gene polymorphisms do not appear to make a difference. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Clinical and genetic outcome determinants of Internet- and group-based cognitive behavior therapy for social anxiety disorder.
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  Data: <searchLink fieldCode="AR" term="%22Hedman%2C+E%2E%22">Hedman, E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Andersson%2C+E%2E%22">Andersson, E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ljótsson%2C+B%2E%22">Ljótsson, B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Andersson%2C+G%2E%22">Andersson, G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schalling%2C+M%2E%22">Schalling, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lindefors%2C+N%2E%22">Lindefors, N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rück%2C+C%2E%22">Rück, C.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. Aug2012, Vol. 126 Issue 2, p126-136. 11p. 1 Diagram, 4 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Cognitive+therapy%22">Cognitive therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Social+anxiety%22">Social anxiety</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety+disorders%22">Anxiety disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Randomized+controlled+trials%22">Randomized controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink>
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  Data: Hedman E, Andersson E, Ljótsson B, Andersson G, Andersson E, Schalling M, Lindefors N, Rück C. Clinical and genetic outcome determinants of Internet- and group-based cognitive behavior therapy for social anxiety disorder (SAD). Objective: No study has investigated clinical or genetic predictors and moderators of Internet-based cognitive behavior therapy (ICBT) compared with cognitive behavioral group therapy for (CBGT) for SAD. Identification of predictors and moderators is essential to the clinician in deciding which treatment to recommend for whom. We aimed to identify clinical and genetic (5-HTTLPR, COMTval158met, and BDNFval66met) predictors and moderators of ICBT and CBGT. Method: We performed three types of analyses on data from a sample comprising participants ( N = 126) who had undergone ICBT or CBGT in a randomized controlled trial. Outcomes were i) end state symptom severity, ii) SAD diagnosis, and iii) clinically significant improvement. Results: The most stable predictors of better treatment response were working full time, having children, less depressive symptoms, higher expectancy of treatment effectiveness, and adhering to treatment. None of the tested gene polymorphisms were associated with treatment outcome. Comorbid general anxiety and depression were moderators meaning that lower levels were associated with a better treatment response in ICBT but not in CBGT. Conclusion: We conclude that demographic factors, symptom burden, adherence, and expectations may play an important role as predictors of treatment outcome. The investigated gene polymorphisms do not appear to make a difference. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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