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Brain dysfunction in fibromyalgia and somatization disorder using proton magnetic resonance spectroscopy: a controlled study.

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Title: Brain dysfunction in fibromyalgia and somatization disorder using proton magnetic resonance spectroscopy: a controlled study.
Authors: Fayed, N. (AUTHOR), Andres, E. (AUTHOR), Rojas, G. (AUTHOR), Moreno, S. (AUTHOR), Serrano‐Blanco, A. (AUTHOR), Roca, M. (AUTHOR), Garcia‐Campayo, J. (AUTHOR)
Source: Acta Psychiatrica Scandinavica. Aug2012, Vol. 126 Issue 2, p115-125. 11p. 1 Black and White Photograph, 3 Charts, 1 Graph.
Subjects: Brain damage, Fibromyalgia, Somatization disorder, Proton magnetic resonance spectroscopy, Primary care
Geographic Terms: Zaragoza (Spain), Spain
Abstract: Fayed N, Andres E, Rojas G, Moreno S, Serrano-Blanco A, Roca M, Garcia-Campayo J. Brain dysfunction in fibromyalgia and somatization disorder using proton magnetic resonance spectroscopy: a controlled study. Objective: To evaluate the brain metabolite patterns in patients with fibromyalgia (FM) and somatization disorder (STD) compared with healthy controls through spectroscopy techniques and correlate these patterns with psychological variables. Method: Design. Controlled, cross-sectional study. Sample. Patients were recruited from primary care in Zaragoza, Spain. The control group was recruited from hospital staff. Patients were administered questionnaires on pain catastrophizing, anxiety, depression, pain, quality of life, and cognitive impairment. All patients underwent Magnetic Resonance Imaging and magnetic resonance spectroscopy (MRS). Results: A significant increase was found in the glutamate + glutamine (Glx) levels in the posterior cingulate cortex (PCC): 10.73 (SD: 0.49) for FM and 9.67 (SD: 1.10) for STD 9.54 (SD: 1.46) compared with controls ( P = 0.043). In the FM + STD group, a correlation between Glx and pain catastrophizing in PCC ( r = 0.397; P = 0.033) and between quality of life and the myo-inositol/creatine ratio in the left hippocampus ( r = −0.500; P = 0.025) was found. To conclude Glutamate seems to be relevant in the molecular processes involved in FM and STD. It also opens the door for Proton MRS (1H-MRS) in STD and suggests that reducing glutamatergic activity through pharmacological treatment could improve the outcome of patients with FM and STD. Conclusion: Glutamate seems to be relevant in the molecular processes involved in FM and STD. It also opens the door for Proton MRS (1H-MRS) in STD and suggests that reducing glutamatergic activity through pharmacological treatment could improve the outcome of patients with FM and STD. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Brain dysfunction in fibromyalgia and somatization disorder using proton magnetic resonance spectroscopy: a controlled study.
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  Data: <searchLink fieldCode="AR" term="%22Fayed%2C+N%2E%22">Fayed, N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Andres%2C+E%2E%22">Andres, E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rojas%2C+G%2E%22">Rojas, G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moreno%2C+S%2E%22">Moreno, S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Serrano‐Blanco%2C+A%2E%22">Serrano‐Blanco, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Roca%2C+M%2E%22">Roca, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Garcia‐Campayo%2C+J%2E%22">Garcia‐Campayo, J.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. Aug2012, Vol. 126 Issue 2, p115-125. 11p. 1 Black and White Photograph, 3 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Brain+damage%22">Brain damage</searchLink><br /><searchLink fieldCode="DE" term="%22Fibromyalgia%22">Fibromyalgia</searchLink><br /><searchLink fieldCode="DE" term="%22Somatization+disorder%22">Somatization disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Proton+magnetic+resonance+spectroscopy%22">Proton magnetic resonance spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Primary+care%22">Primary care</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Zaragoza+%28Spain%29%22">Zaragoza (Spain)</searchLink><br /><searchLink fieldCode="DE" term="%22Spain%22">Spain</searchLink>
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  Data: Fayed N, Andres E, Rojas G, Moreno S, Serrano-Blanco A, Roca M, Garcia-Campayo J. Brain dysfunction in fibromyalgia and somatization disorder using proton magnetic resonance spectroscopy: a controlled study. Objective: To evaluate the brain metabolite patterns in patients with fibromyalgia (FM) and somatization disorder (STD) compared with healthy controls through spectroscopy techniques and correlate these patterns with psychological variables. Method: Design. Controlled, cross-sectional study. Sample. Patients were recruited from primary care in Zaragoza, Spain. The control group was recruited from hospital staff. Patients were administered questionnaires on pain catastrophizing, anxiety, depression, pain, quality of life, and cognitive impairment. All patients underwent Magnetic Resonance Imaging and magnetic resonance spectroscopy (MRS). Results: A significant increase was found in the glutamate + glutamine (Glx) levels in the posterior cingulate cortex (PCC): 10.73 (SD: 0.49) for FM and 9.67 (SD: 1.10) for STD 9.54 (SD: 1.46) compared with controls ( P = 0.043). In the FM + STD group, a correlation between Glx and pain catastrophizing in PCC ( r = 0.397; P = 0.033) and between quality of life and the myo-inositol/creatine ratio in the left hippocampus ( r = −0.500; P = 0.025) was found. To conclude Glutamate seems to be relevant in the molecular processes involved in FM and STD. It also opens the door for Proton MRS (1H-MRS) in STD and suggests that reducing glutamatergic activity through pharmacological treatment could improve the outcome of patients with FM and STD. Conclusion: Glutamate seems to be relevant in the molecular processes involved in FM and STD. It also opens the door for Proton MRS (1H-MRS) in STD and suggests that reducing glutamatergic activity through pharmacological treatment could improve the outcome of patients with FM and STD. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Type: general
      – SubjectFull: Fibromyalgia
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      – SubjectFull: Somatization disorder
        Type: general
      – SubjectFull: Proton magnetic resonance spectroscopy
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              Text: Aug2012
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