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Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets.

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Title: Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets.
Authors: Herfst, Sander, Schrauwen, Eerie J. A., Linster, Martin, Chutinimitkul, Salin, de Wit, Emmie, Munster, Vincent J., Sorrell, Erin M., Bestebroer, Theo M., Burke, David F., Smith, Derek J., Rimmelzwaan, Guus F., Osterhaus, Albert D. M. E., Fouchier, Ron A. M.
Source: Science (pre-March 2025). 6/22/2012, Vol. 336 Issue 6088, p1534-1541. 8p.
Subjects: Infectious disease transmission, H5N1 Influenza, Airborne infection, Avian influenza epidemiology, Genetic engineering, Recombinant viruses, Ferret, Animal models in research
Abstract: Highly pathogenic avian influenza A/H5N1 virus can cause morbidity and mortality in humans but thus far has not acquired the ability to be transmitted by aerosol or respiratory droplet ("airborne transmission") between humans. To address the concern that the virus could acquire this ability under natural conditions, we genetically modified A/H5N1 virus by site-directed mutagenesis and subsequent serial passage in ferrets. The genetically modified A/H5N1 virus acquired mutations during passage in ferrets, ultimately becoming airborne transmissible in ferrets. None of the recipient ferrets died after airborne infection with the mutant A/H5N1 viruses. Four amino acid substitutions in the host receptor-binding protein hemagglutinin, and one in the polymerase complex protein basic polymerase 2, were consistently present in airborne-transmitted viruses. The transmissible viruses were sensitive to the antiviral drug oseltamivir and reacted well with antisera raised against H5 influenza vaccine strains. Thus, avian A/H5N1 influenza viruses can acquire the capacity for airborne transmission between mammals without recombination in an intermediate host and therefore constitute a risk for human pandemic influenza. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets.
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  Data: <searchLink fieldCode="AR" term="%22Herfst%2C+Sander%22">Herfst, Sander</searchLink><br /><searchLink fieldCode="AR" term="%22Schrauwen%2C+Eerie+J%2E+A%2E%22">Schrauwen, Eerie J. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Linster%2C+Martin%22">Linster, Martin</searchLink><br /><searchLink fieldCode="AR" term="%22Chutinimitkul%2C+Salin%22">Chutinimitkul, Salin</searchLink><br /><searchLink fieldCode="AR" term="%22de+Wit%2C+Emmie%22">de Wit, Emmie</searchLink><br /><searchLink fieldCode="AR" term="%22Munster%2C+Vincent+J%2E%22">Munster, Vincent J.</searchLink><br /><searchLink fieldCode="AR" term="%22Sorrell%2C+Erin+M%2E%22">Sorrell, Erin M.</searchLink><br /><searchLink fieldCode="AR" term="%22Bestebroer%2C+Theo+M%2E%22">Bestebroer, Theo M.</searchLink><br /><searchLink fieldCode="AR" term="%22Burke%2C+David+F%2E%22">Burke, David F.</searchLink><br /><searchLink fieldCode="AR" term="%22Smith%2C+Derek+J%2E%22">Smith, Derek J.</searchLink><br /><searchLink fieldCode="AR" term="%22Rimmelzwaan%2C+Guus+F%2E%22">Rimmelzwaan, Guus F.</searchLink><br /><searchLink fieldCode="AR" term="%22Osterhaus%2C+Albert+D%2E+M%2E+E%2E%22">Osterhaus, Albert D. M. E.</searchLink><br /><searchLink fieldCode="AR" term="%22Fouchier%2C+Ron+A%2E+M%2E%22">Fouchier, Ron A. M.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 6/22/2012, Vol. 336 Issue 6088, p1534-1541. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Infectious+disease+transmission%22">Infectious disease transmission</searchLink><br /><searchLink fieldCode="DE" term="%22H5N1+Influenza%22">H5N1 Influenza</searchLink><br /><searchLink fieldCode="DE" term="%22Airborne+infection%22">Airborne infection</searchLink><br /><searchLink fieldCode="DE" term="%22Avian+influenza+epidemiology%22">Avian influenza epidemiology</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+engineering%22">Genetic engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Recombinant+viruses%22">Recombinant viruses</searchLink><br /><searchLink fieldCode="DE" term="%22Ferret%22">Ferret</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+models+in+research%22">Animal models in research</searchLink>
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  Data: Highly pathogenic avian influenza A/H5N1 virus can cause morbidity and mortality in humans but thus far has not acquired the ability to be transmitted by aerosol or respiratory droplet ("airborne transmission") between humans. To address the concern that the virus could acquire this ability under natural conditions, we genetically modified A/H5N1 virus by site-directed mutagenesis and subsequent serial passage in ferrets. The genetically modified A/H5N1 virus acquired mutations during passage in ferrets, ultimately becoming airborne transmissible in ferrets. None of the recipient ferrets died after airborne infection with the mutant A/H5N1 viruses. Four amino acid substitutions in the host receptor-binding protein hemagglutinin, and one in the polymerase complex protein basic polymerase 2, were consistently present in airborne-transmitted viruses. The transmissible viruses were sensitive to the antiviral drug oseltamivir and reacted well with antisera raised against H5 influenza vaccine strains. Thus, avian A/H5N1 influenza viruses can acquire the capacity for airborne transmission between mammals without recombination in an intermediate host and therefore constitute a risk for human pandemic influenza. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1126/science.1213362
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        Text: English
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        PageCount: 8
        StartPage: 1534
    Subjects:
      – SubjectFull: Infectious disease transmission
        Type: general
      – SubjectFull: H5N1 Influenza
        Type: general
      – SubjectFull: Airborne infection
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      – SubjectFull: Avian influenza epidemiology
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      – SubjectFull: Genetic engineering
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      – SubjectFull: Recombinant viruses
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      – SubjectFull: Ferret
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      – SubjectFull: Animal models in research
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              Text: 6/22/2012
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