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The Potential for Respiratory Droplet--Transmissible A/H5N1 Influenza Virus to Evolve in a Mammalian Host.

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Title: The Potential for Respiratory Droplet--Transmissible A/H5N1 Influenza Virus to Evolve in a Mammalian Host.
Authors: Russell, Colin A., Fonville, Judith M., Brown, André E. X., Burke, David F., Smith, David L., James, Sarah L., Herfst, Sander, van Boheemen, Sander, Linster, Martin, Schrauwen, Eefje J., Katzelnick, Leah, Mosterín, Ana, Kuiken, Thijs, Maher, Eileen, Neumann, Gabriele, Osterhaus, Albert D. M. E., Kawaoka, Yoshihiro, Fouchier, Ron A. M., Smith, Derek J.
Source: Science (pre-March 2025). 6/22/2012, Vol. 336 Issue 6088, p1541-1547. 7p.
Subjects: H5N1 Influenza, Airborne infection, Host-virus relationships, Viral evolution, Microbiology, Pandemics, Infectious disease transmission, Disease risk factors
Abstract: Avian A/H5N1 influenza viruses pose a pandemic threat. As few as five amino acid substitutions, or four with reassortment, might be sufficient for mammal-to-mammal transmission through respiratory droplets. From surveillance data, we found that two of these substitutions are common in A/H5N1 viruses, and thus, some viruses might require only three additional substitutions to become transmissible via respiratory droplets between mammals. We used a mathematical model of within-host virus evolution to study factors that could increase and decrease the probability of the remaining substitutions evolving after the virus has infected a mammalian host. These factors, combined with the presence of some of these substitutions in circulating strains, make a virus evolving in nature a potentially serious threat. These results highlight critical areas in which more data are needed for assessing, and potentially averting, this threat. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The Potential for Respiratory Droplet--Transmissible A/H5N1 Influenza Virus to Evolve in a Mammalian Host.
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 6/22/2012, Vol. 336 Issue 6088, p1541-1547. 7p.
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  Data: Avian A/H5N1 influenza viruses pose a pandemic threat. As few as five amino acid substitutions, or four with reassortment, might be sufficient for mammal-to-mammal transmission through respiratory droplets. From surveillance data, we found that two of these substitutions are common in A/H5N1 viruses, and thus, some viruses might require only three additional substitutions to become transmissible via respiratory droplets between mammals. We used a mathematical model of within-host virus evolution to study factors that could increase and decrease the probability of the remaining substitutions evolving after the virus has infected a mammalian host. These factors, combined with the presence of some of these substitutions in circulating strains, make a virus evolving in nature a potentially serious threat. These results highlight critical areas in which more data are needed for assessing, and potentially averting, this threat. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=77688818
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