Inter-individual diversity and intra-individual stability of amphetamine-induced sensitization of frequency-modulated 50-kHz vocalization in Sprague-Dawley rats.
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| Title: | Inter-individual diversity and intra-individual stability of amphetamine-induced sensitization of frequency-modulated 50-kHz vocalization in Sprague-Dawley rats. |
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| Authors: | Taracha, Ewa, Hamed, Adam, Krząścik, Paweł, Lehner, Małgorzata, Skórzewska, Anna, Płaźnik, Adam, Chrapusta, Stanisław |
| Source: | Psychopharmacology. Aug2012, Vol. 222 Issue 4, p619-632. 14p. 1 Diagram, 10 Graphs. |
| Subjects: | Individual differences, Amphetamines, Sprague Dawley rats, Drug addiction, Psychopharmacology, Health outcome assessment |
| Abstract: | Rationale: Propensity for drug dependence shows great diversity that is related to intrinsic neurobiological factors. This diversity is important both for the understanding of these traits and for the development of therapies. Objectives: The goals of the study were (1) to define, using ultrasonic vocalization characteristics, inter-individual differences in rats' propensity for sensitization to amphetamine, (2) to test whether possible resistance to this effect could be overcome with repetitive treatment, and (3) to seek useful predictors of the propensity. Methods: Rats were subject to tests meant to characterize their anxiety, pain sensitivity, and responses to novelty and natural rewards. Then they were subject to the so-called two-injection protocol of sensitization (using amphetamine) followed by 2 weeks of daily amphetamine treatment, 2-week withdrawal, and final amphetamine challenge. The development and outcome of sensitization were monitored by measuring 50-kHz vocalization. Results: The two-injection protocol yielded three patterns of changes in the frequency-modulated 50-kHz vocalization response to amphetamine. These patterns persisted after completion of the extended drug treatment. Rats with lower sensitivity to pain or with longer latency of their vocalization response to the first drug exposure showed an increased propensity for ultrasonic vocalization sensitization. Conclusion: Vulnerability to sensitization of frequency-modulated 50-kHz vocalization response of Sprague-Dawley rats to amphetamine, which supposedly reflects rats' propensity for amphetamine dependence, shows large inter-individual diversity. Resistance to this effect, which is evident in a majority of the rats, cannot be overcome even with prolonged intermittent drug treatment under the conditions (novelty) that promote sensitization. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 78030183 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Inter-individual diversity and intra-individual stability of amphetamine-induced sensitization of frequency-modulated 50-kHz vocalization in Sprague-Dawley rats. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Taracha%2C+Ewa%22">Taracha, Ewa</searchLink><br /><searchLink fieldCode="AR" term="%22Hamed%2C+Adam%22">Hamed, Adam</searchLink><br /><searchLink fieldCode="AR" term="%22Krząścik%2C+Paweł%22">Krząścik, Paweł</searchLink><br /><searchLink fieldCode="AR" term="%22Lehner%2C+Małgorzata%22">Lehner, Małgorzata</searchLink><br /><searchLink fieldCode="AR" term="%22Skórzewska%2C+Anna%22">Skórzewska, Anna</searchLink><br /><searchLink fieldCode="AR" term="%22Płaźnik%2C+Adam%22">Płaźnik, Adam</searchLink><br /><searchLink fieldCode="AR" term="%22Chrapusta%2C+Stanisław%22">Chrapusta, Stanisław</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Aug2012, Vol. 222 Issue 4, p619-632. 14p. 1 Diagram, 10 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Individual+differences%22">Individual differences</searchLink><br /><searchLink fieldCode="DE" term="%22Amphetamines%22">Amphetamines</searchLink><br /><searchLink fieldCode="DE" term="%22Sprague+Dawley+rats%22">Sprague Dawley rats</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+addiction%22">Drug addiction</searchLink><br /><searchLink fieldCode="DE" term="%22Psychopharmacology%22">Psychopharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Health+outcome+assessment%22">Health outcome assessment</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rationale: Propensity for drug dependence shows great diversity that is related to intrinsic neurobiological factors. This diversity is important both for the understanding of these traits and for the development of therapies. Objectives: The goals of the study were (1) to define, using ultrasonic vocalization characteristics, inter-individual differences in rats' propensity for sensitization to amphetamine, (2) to test whether possible resistance to this effect could be overcome with repetitive treatment, and (3) to seek useful predictors of the propensity. Methods: Rats were subject to tests meant to characterize their anxiety, pain sensitivity, and responses to novelty and natural rewards. Then they were subject to the so-called two-injection protocol of sensitization (using amphetamine) followed by 2 weeks of daily amphetamine treatment, 2-week withdrawal, and final amphetamine challenge. The development and outcome of sensitization were monitored by measuring 50-kHz vocalization. Results: The two-injection protocol yielded three patterns of changes in the frequency-modulated 50-kHz vocalization response to amphetamine. These patterns persisted after completion of the extended drug treatment. Rats with lower sensitivity to pain or with longer latency of their vocalization response to the first drug exposure showed an increased propensity for ultrasonic vocalization sensitization. Conclusion: Vulnerability to sensitization of frequency-modulated 50-kHz vocalization response of Sprague-Dawley rats to amphetamine, which supposedly reflects rats' propensity for amphetamine dependence, shows large inter-individual diversity. Resistance to this effect, which is evident in a majority of the rats, cannot be overcome even with prolonged intermittent drug treatment under the conditions (novelty) that promote sensitization. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-012-2658-4 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 619 Subjects: – SubjectFull: Individual differences Type: general – SubjectFull: Amphetamines Type: general – SubjectFull: Sprague Dawley rats Type: general – SubjectFull: Drug addiction Type: general – SubjectFull: Psychopharmacology Type: general – SubjectFull: Health outcome assessment Type: general Titles: – TitleFull: Inter-individual diversity and intra-individual stability of amphetamine-induced sensitization of frequency-modulated 50-kHz vocalization in Sprague-Dawley rats. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Taracha, Ewa – PersonEntity: Name: NameFull: Hamed, Adam – PersonEntity: Name: NameFull: Krząścik, Paweł – PersonEntity: Name: NameFull: Lehner, Małgorzata – PersonEntity: Name: NameFull: Skórzewska, Anna – PersonEntity: Name: NameFull: Płaźnik, Adam – PersonEntity: Name: NameFull: Chrapusta, Stanisław IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 08 Text: Aug2012 Type: published Y: 2012 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 222 – Type: issue Value: 4 Titles: – TitleFull: Psychopharmacology Type: main |
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