Winter Season Temperature Drops and Sulfur Dioxide Levels Affect on Exacerbation of Refractory Asthma in South Korea: A Time-Trend Controlled Case-Crossover Study Using Soonchunhyang Asthma Cohort Data.
Saved in:
| Title: | Winter Season Temperature Drops and Sulfur Dioxide Levels Affect on Exacerbation of Refractory Asthma in South Korea: A Time-Trend Controlled Case-Crossover Study Using Soonchunhyang Asthma Cohort Data. |
|---|---|
| Authors: | Kim, Sungroul (AUTHOR), Kim, Yongbae (AUTHOR), Lee, Mee-Ri (AUTHOR), Kim, Junhyoung (AUTHOR), Jung, Ara (AUTHOR), Park, Jong Sook (AUTHOR), Jang, An-Soo (AUTHOR), Park, Sung-Woo (AUTHOR), Uh, Soo-Taek (AUTHOR), Choi, Jae Sung (AUTHOR), Kim, Young Hoon (AUTHOR), Buckley, Timothy (AUTHOR), Park, Choon-Sik (AUTHOR) |
| Source: | Journal of Asthma. Sep2012, Vol. 49 Issue 7, p679-687. 9p. 3 Charts, 1 Graph. |
| Subjects: | Asthma treatment, Physiological effects of sulfur dioxide, Winter, Temperature effect, Disease exacerbation, Cohort analysis, American Thoracic Society |
| Geographic Terms: | South Korea |
| Abstract: | Objective. According to the American Thoracic Society, approximately 5% of all asthmatics have refractory asthma (RA); these patients fail to recover lost lung function even after long-term treatment with high doses of medications. Methods. Using a time-trend controlled case-crossover study design, we calculated odds ratios to evaluate whether exposure to ambient air pollutants and certain meteorological conditions on the day of admission (Lag 0) and up to 3 days before admission (Lag1 through Lag 3) were associated with acute RA exacerbation. Results were obtained after controlling for the effects of seasonality, smoking, and allergen sensitivity; we stratified our data into four seasons with respect to the median temperature of each month and further stratified them according to self-reported smoking status and skin-prick test results. Results. In our study, RA patients ( n = 82), living in metropolitan city of Seoul and Kyunggi Province, accounted for 3.7% of all asthmatics ( n = 2298) registered in our asthma cohort between 2005 and 2009. In winter, a 1°C decrease in ambient temperature and a 1 ppb increase in sulfur dioxide concentration on the day of Lag 1 were associated with 14.8% (95% confidence interval [CI]: 0.9-26.7) and 19.7% (95% CI: 3.3-38.7) increases in the risk of RA exacerbation among nonsmokers, respectively. Similar associations were obtained on the day of Lag 2. The association remained unchanged after excluding patients sensitive to Dermatophagoides farinae and Dermatophagoides pteronyssinus. Conclusions. Exposure to temperature drops and increased sulfur dioxide concentrations are positively associated with the occurrence of acute RA exacerbation during winter with 1 or 2 day lags. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 78712590 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Winter Season Temperature Drops and Sulfur Dioxide Levels Affect on Exacerbation of Refractory Asthma in South Korea: A Time-Trend Controlled Case-Crossover Study Using Soonchunhyang Asthma Cohort Data. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kim%2C+Sungroul%22">Kim, Sungroul</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Yongbae%22">Kim, Yongbae</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Mee-Ri%22">Lee, Mee-Ri</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Junhyoung%22">Kim, Junhyoung</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jung%2C+Ara%22">Jung, Ara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park%2C+Jong+Sook%22">Park, Jong Sook</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jang%2C+An-Soo%22">Jang, An-Soo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park%2C+Sung-Woo%22">Park, Sung-Woo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Uh%2C+Soo-Taek%22">Uh, Soo-Taek</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Choi%2C+Jae+Sung%22">Choi, Jae Sung</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Young+Hoon%22">Kim, Young Hoon</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Buckley%2C+Timothy%22">Buckley, Timothy</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park%2C+Choon-Sik%22">Park, Choon-Sik</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Asthma%22">Journal of Asthma</searchLink>. Sep2012, Vol. 49 Issue 7, p679-687. 9p. 3 Charts, 1 Graph. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Asthma+treatment%22">Asthma treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Physiological+effects+of+sulfur+dioxide%22">Physiological effects of sulfur dioxide</searchLink><br /><searchLink fieldCode="DE" term="%22Winter%22">Winter</searchLink><br /><searchLink fieldCode="DE" term="%22Temperature+effect%22">Temperature effect</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+exacerbation%22">Disease exacerbation</searchLink><br /><searchLink fieldCode="DE" term="%22Cohort+analysis%22">Cohort analysis</searchLink><br /><searchLink fieldCode="DE" term="%22American+Thoracic+Society%22">American Thoracic Society</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22South+Korea%22">South Korea</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective. According to the American Thoracic Society, approximately 5% of all asthmatics have refractory asthma (RA); these patients fail to recover lost lung function even after long-term treatment with high doses of medications. Methods. Using a time-trend controlled case-crossover study design, we calculated odds ratios to evaluate whether exposure to ambient air pollutants and certain meteorological conditions on the day of admission (Lag 0) and up to 3 days before admission (Lag1 through Lag 3) were associated with acute RA exacerbation. Results were obtained after controlling for the effects of seasonality, smoking, and allergen sensitivity; we stratified our data into four seasons with respect to the median temperature of each month and further stratified them according to self-reported smoking status and skin-prick test results. Results. In our study, RA patients ( n = 82), living in metropolitan city of Seoul and Kyunggi Province, accounted for 3.7% of all asthmatics ( n = 2298) registered in our asthma cohort between 2005 and 2009. In winter, a 1°C decrease in ambient temperature and a 1 ppb increase in sulfur dioxide concentration on the day of Lag 1 were associated with 14.8% (95% confidence interval [CI]: 0.9-26.7) and 19.7% (95% CI: 3.3-38.7) increases in the risk of RA exacerbation among nonsmokers, respectively. Similar associations were obtained on the day of Lag 2. The association remained unchanged after excluding patients sensitive to Dermatophagoides farinae and Dermatophagoides pteronyssinus. Conclusions. Exposure to temperature drops and increased sulfur dioxide concentrations are positively associated with the occurrence of acute RA exacerbation during winter with 1 or 2 day lags. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=78712590 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3109/02770903.2012.702839 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 679 Subjects: – SubjectFull: Asthma treatment Type: general – SubjectFull: Physiological effects of sulfur dioxide Type: general – SubjectFull: Winter Type: general – SubjectFull: Temperature effect Type: general – SubjectFull: Disease exacerbation Type: general – SubjectFull: Cohort analysis Type: general – SubjectFull: American Thoracic Society Type: general – SubjectFull: South Korea Type: general Titles: – TitleFull: Winter Season Temperature Drops and Sulfur Dioxide Levels Affect on Exacerbation of Refractory Asthma in South Korea: A Time-Trend Controlled Case-Crossover Study Using Soonchunhyang Asthma Cohort Data. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kim, Sungroul – PersonEntity: Name: NameFull: Kim, Yongbae – PersonEntity: Name: NameFull: Lee, Mee-Ri – PersonEntity: Name: NameFull: Kim, Junhyoung – PersonEntity: Name: NameFull: Jung, Ara – PersonEntity: Name: NameFull: Park, Jong Sook – PersonEntity: Name: NameFull: Jang, An-Soo – PersonEntity: Name: NameFull: Park, Sung-Woo – PersonEntity: Name: NameFull: Uh, Soo-Taek – PersonEntity: Name: NameFull: Choi, Jae Sung – PersonEntity: Name: NameFull: Kim, Young Hoon – PersonEntity: Name: NameFull: Buckley, Timothy – PersonEntity: Name: NameFull: Park, Choon-Sik IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2012 Type: published Y: 2012 Identifiers: – Type: issn-print Value: 02770903 Numbering: – Type: volume Value: 49 – Type: issue Value: 7 Titles: – TitleFull: Journal of Asthma Type: main |
| ResultId | 1 |
