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INFLUENCE OF ANTIOXIDANTS ON BLOOD-BRAIN BARRIER PERMEABILITY DURING ADRENALINE-INDUCED HYPERTENSION.

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Title: INFLUENCE OF ANTIOXIDANTS ON BLOOD-BRAIN BARRIER PERMEABILITY DURING ADRENALINE-INDUCED HYPERTENSION.
Authors: ÖZTAŞ, B., Erkin, E., Dural, E., Isbir, T.
Source: International Journal of Neuroscience. 2000, Vol. 105 Issue 1-4, p27. 9p. 1 Chart, 1 Graph.
Subjects: Antioxidants, Blood-brain barrier, Adrenaline, Hypertension
Abstract: We have examined the effect of antioxidants (vitamin E, and selenium) on the blood brain barrier permeability during adreneline-induced acute hypertension in the female rats. The rats supplemented with nontoxic doses of sodium selenite in drinking water for three months or vitamin E was given intraperitoneally before adrenaline-induced acute hypertension. Evans-blue was used as a blood-brain barrier tracer. Mean values for Evans-blue dye were found to be 0.28 ± 0.04 μg/g tissue in control animals and 1.0 ± 0.2μg/g tissue after adrenaline-induced acute hypertension (p < .01). Rats pretreated with selenium or vitamin E also showed macroscopic leakage of Evans-blue albumin after adrenaline injection i.e., there was no significant difference in protein extravasation between untreated and treated animals (p > .5). The mean value for Evans-blue dye was found to be 1.0±0.2ug/g tissue in acute hypertension group, 0.9±0.2ug/g tissue in selenium pretreated animals and 1.0±0.2(ig/g tissue vitamin E injected animals after acute hypertension. The results show that antioxidants did not influence the blood—brain barrier breakdown during adrenaline-induced acute hypertension. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: INFLUENCE OF ANTIOXIDANTS ON BLOOD-BRAIN BARRIER PERMEABILITY DURING ADRENALINE-INDUCED HYPERTENSION.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22International+Journal+of+Neuroscience%22&quot;&gt;International Journal of Neuroscience&lt;/searchLink&gt;. 2000, Vol. 105 Issue 1-4, p27. 9p. 1 Chart, 1 Graph.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Antioxidants%22&quot;&gt;Antioxidants&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Blood-brain+barrier%22&quot;&gt;Blood-brain barrier&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Adrenaline%22&quot;&gt;Adrenaline&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Hypertension%22&quot;&gt;Hypertension&lt;/searchLink&gt;
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  Data: We have examined the effect of antioxidants (vitamin E, and selenium) on the blood brain barrier permeability during adreneline-induced acute hypertension in the female rats. The rats supplemented with nontoxic doses of sodium selenite in drinking water for three months or vitamin E was given intraperitoneally before adrenaline-induced acute hypertension. Evans-blue was used as a blood-brain barrier tracer. Mean values for Evans-blue dye were found to be 0.28 &#177; 0.04 μg/g tissue in control animals and 1.0 &#177; 0.2μg/g tissue after adrenaline-induced acute hypertension (p &lt; .01). Rats pretreated with selenium or vitamin E also showed macroscopic leakage of Evans-blue albumin after adrenaline injection i.e., there was no significant difference in protein extravasation between untreated and treated animals (p &gt; .5). The mean value for Evans-blue dye was found to be 1.0&#177;0.2ug/g tissue in acute hypertension group, 0.9&#177;0.2ug/g tissue in selenium pretreated animals and 1.0&#177;0.2(ig/g tissue vitamin E injected animals after acute hypertension. The results show that antioxidants did not influence the blood—brain barrier breakdown during adrenaline-induced acute hypertension. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of International Journal of Neuroscience is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Text: English
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        StartPage: 27
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      – SubjectFull: Antioxidants
        Type: general
      – SubjectFull: Blood-brain barrier
        Type: general
      – SubjectFull: Adrenaline
        Type: general
      – SubjectFull: Hypertension
        Type: general
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      – TitleFull: INFLUENCE OF ANTIOXIDANTS ON BLOOD-BRAIN BARRIER PERMEABILITY DURING ADRENALINE-INDUCED HYPERTENSION.
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            NameFull: ÖZTAŞ, B.
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            NameFull: Erkin, E.
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            NameFull: Dural, E.
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            NameFull: Isbir, T.
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            – D: 01
              M: 11
              Text: 2000
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              Y: 2000
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