View in EDS HTML Full Text PDF Full Text

Effect of intermittent theta-burst stimulation on akinesia and sensorimotor integration in patients with Parkinson's disease.

Saved in:
Bibliographic Details
Title: Effect of intermittent theta-burst stimulation on akinesia and sensorimotor integration in patients with Parkinson's disease.
Authors: Degardin, Adrian (AUTHOR), Devos, David (AUTHOR), Defebvre, Luc (AUTHOR), Destée, Alain (AUTHOR), Plomhause, Lucie (AUTHOR), Derambure, Philippe (AUTHOR), Devanne, Hervé (AUTHOR)
Source: European Journal of Neuroscience. Sep2012, Vol. 36 Issue 5, p2669-2678. 10p. 1 Diagram, 3 Charts, 4 Graphs.
Subjects: Parkinson's disease, Transcranial magnetic stimulation, Sensorimotor integration, Dopamine, Dopa, Motor cortex, Afferent pathways
Abstract: High-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) has been shown to reduce akinesia in Parkinson's disease (PD). Given that the processing of sensory afferents is deficient in PD and might be involved in akinesia, we sought to determine whether or not the application of very HF rTMS [intermittent theta-burst stimulation (iTBS) protocol] over the M1 affected sensorimotor integration (SMI) and akinesia. The experiments were carried out in: (i) 11 patients taking their usual dopaminergic treatment ('on-drug'); (ii) eight of the latter patients after withdrawal of dopaminergic treatment ('off-drug'); and (iii) 10 de novo (drug-naive) patients. Sham stimulation was applied in 11 other patients in the 'on-drug' condition. SMI was investigated by conditioning a supra-threshold transcranial magnetic stimulation pulse in the motor region controlling the abductor pollicis brevis with a nerve shock over the median nerve at time intervals corresponding to short- and long-latency afferent inhibition (SAI and LAI) and afferent-induced facilitation (AIF). Akinesia was assessed with a pointing test. In on-drug, off-drug and de novo patients, akinesia in the contralateral arm was lower after iTBS. Sham stimulation had no effect. In on-drug patients (but not other groups), SMI was also influenced by iTBS, with an increase in AIF. No changes in SAI and LAI were observed. Our data suggest that iTBS might improve both akinesia and sensory processing in patients with PD taking levodopa. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 79611640
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Effect of intermittent theta-burst stimulation on akinesia and sensorimotor integration in patients with Parkinson's disease.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Degardin%2C+Adrian%22">Degardin, Adrian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Devos%2C+David%22">Devos, David</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Defebvre%2C+Luc%22">Defebvre, Luc</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Destée%2C+Alain%22">Destée, Alain</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Plomhause%2C+Lucie%22">Plomhause, Lucie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Derambure%2C+Philippe%22">Derambure, Philippe</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Devanne%2C+Hervé%22">Devanne, Hervé</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Sep2012, Vol. 36 Issue 5, p2669-2678. 10p. 1 Diagram, 3 Charts, 4 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Transcranial+magnetic+stimulation%22">Transcranial magnetic stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Sensorimotor+integration%22">Sensorimotor integration</searchLink><br /><searchLink fieldCode="DE" term="%22Dopamine%22">Dopamine</searchLink><br /><searchLink fieldCode="DE" term="%22Dopa%22">Dopa</searchLink><br /><searchLink fieldCode="DE" term="%22Motor+cortex%22">Motor cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Afferent+pathways%22">Afferent pathways</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: High-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) has been shown to reduce akinesia in Parkinson's disease (PD). Given that the processing of sensory afferents is deficient in PD and might be involved in akinesia, we sought to determine whether or not the application of very HF rTMS [intermittent theta-burst stimulation (iTBS) protocol] over the M1 affected sensorimotor integration (SMI) and akinesia. The experiments were carried out in: (i) 11 patients taking their usual dopaminergic treatment ('on-drug'); (ii) eight of the latter patients after withdrawal of dopaminergic treatment ('off-drug'); and (iii) 10 de novo (drug-naive) patients. Sham stimulation was applied in 11 other patients in the 'on-drug' condition. SMI was investigated by conditioning a supra-threshold transcranial magnetic stimulation pulse in the motor region controlling the abductor pollicis brevis with a nerve shock over the median nerve at time intervals corresponding to short- and long-latency afferent inhibition (SAI and LAI) and afferent-induced facilitation (AIF). Akinesia was assessed with a pointing test. In on-drug, off-drug and de novo patients, akinesia in the contralateral arm was lower after iTBS. Sham stimulation had no effect. In on-drug patients (but not other groups), SMI was also influenced by iTBS, with an increase in AIF. No changes in SAI and LAI were observed. Our data suggest that iTBS might improve both akinesia and sensory processing in patients with PD taking levodopa. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=79611640
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/j.1460-9568.2012.08158.x
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 2669
    Subjects:
      – SubjectFull: Parkinson's disease
        Type: general
      – SubjectFull: Transcranial magnetic stimulation
        Type: general
      – SubjectFull: Sensorimotor integration
        Type: general
      – SubjectFull: Dopamine
        Type: general
      – SubjectFull: Dopa
        Type: general
      – SubjectFull: Motor cortex
        Type: general
      – SubjectFull: Afferent pathways
        Type: general
    Titles:
      – TitleFull: Effect of intermittent theta-burst stimulation on akinesia and sensorimotor integration in patients with Parkinson's disease.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Degardin, Adrian
      – PersonEntity:
          Name:
            NameFull: Devos, David
      – PersonEntity:
          Name:
            NameFull: Defebvre, Luc
      – PersonEntity:
          Name:
            NameFull: Destée, Alain
      – PersonEntity:
          Name:
            NameFull: Plomhause, Lucie
      – PersonEntity:
          Name:
            NameFull: Derambure, Philippe
      – PersonEntity:
          Name:
            NameFull: Devanne, Hervé
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 09
              Text: Sep2012
              Type: published
              Y: 2012
          Identifiers:
            – Type: issn-print
              Value: 0953816X
          Numbering:
            – Type: volume
              Value: 36
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: European Journal of Neuroscience
              Type: main
ResultId 1