Detection of microbleeds in post-mortem brains of patients with frontotemporal lobar degeneration: a 7.0-Tesla magnetic resonance imaging study with neuropathological correlates.
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| Title: | Detection of microbleeds in post-mortem brains of patients with frontotemporal lobar degeneration: a 7.0-Tesla magnetic resonance imaging study with neuropathological correlates. |
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| Authors: | Reuck, J., Deramecourt, V., Cordonnier, C., Auger, F., Durieux, N., Bordet, R., Maurage, C. A., Leys, D., Pasquier, F. |
| Source: | European Journal of Neurology. Oct2012, Vol. 19 Issue 10, p1355-1360. 6p. |
| Subjects: | Neurological disorders, Brain physiology, Magnetic resonance imaging, Frontotemporal dementia, Alzheimer's patients, Cerebrovascular disease, Diagnosis |
| Abstract: | Background Microbleeds ( MBs) are frequently detected in brains of patients with Alzheimer dementia and rare in those with frontotemporal lobar degeneration ( FTLD). This study investigates for the first time the topographic distribution of MBs on a T2*-weighted gradient-echo 7.0-T magnetic resonance imaging ( MRI) in post-mortem FTLD brains. Patients and methods The neuropathological and MRI findings in 12 FTLD brains were compared with eight age-matched controls. The presence of cerebrovascular lesions was evaluated on a coronal section of a cerebral hemisphere at the level of the mamillary body and on a horizontal section through pons and cerebellum. On MRI, the distribution and the number of cortical focal signal intensity losses, representing MBs, were assessed on coronal sections at the frontal, the central and the occipital level of a cerebral hemisphere. Results Overall, cerebrovascular lesions were rare. Only white matter damage was significantly more severe in FTLD brains compared with controls ( P = 0.03). On MRI, MBs were only significantly prevalent in the deep cortical layers ( P < 0.01) and borderline increased in the middle cortical layers ( P = 0.07) of the frontal section. Conclusions Cerebrovascular lesions are rare in FTLD. The white matter damage has to be considered as part of the neurodegenerative process. MBs prevail in the frontal regions with the most severe neuronal damage and probably represent associated disruption of the blood-brain barrier. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 79956581 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Detection of microbleeds in post-mortem brains of patients with frontotemporal lobar degeneration: a 7.0-Tesla magnetic resonance imaging study with neuropathological correlates. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Reuck%2C+J%2E%22">Reuck, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Deramecourt%2C+V%2E%22">Deramecourt, V.</searchLink><br /><searchLink fieldCode="AR" term="%22Cordonnier%2C+C%2E%22">Cordonnier, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Auger%2C+F%2E%22">Auger, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Durieux%2C+N%2E%22">Durieux, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Bordet%2C+R%2E%22">Bordet, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Maurage%2C+C%2E+A%2E%22">Maurage, C. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Leys%2C+D%2E%22">Leys, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Pasquier%2C+F%2E%22">Pasquier, F.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Oct2012, Vol. 19 Issue 10, p1355-1360. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Neurological+disorders%22">Neurological disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+physiology%22">Brain physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Frontotemporal+dementia%22">Frontotemporal dementia</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+patients%22">Alzheimer's patients</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebrovascular+disease%22">Cerebrovascular disease</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis%22">Diagnosis</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background Microbleeds ( MBs) are frequently detected in brains of patients with Alzheimer dementia and rare in those with frontotemporal lobar degeneration ( FTLD). This study investigates for the first time the topographic distribution of MBs on a T2*-weighted gradient-echo 7.0-T magnetic resonance imaging ( MRI) in post-mortem FTLD brains. Patients and methods The neuropathological and MRI findings in 12 FTLD brains were compared with eight age-matched controls. The presence of cerebrovascular lesions was evaluated on a coronal section of a cerebral hemisphere at the level of the mamillary body and on a horizontal section through pons and cerebellum. On MRI, the distribution and the number of cortical focal signal intensity losses, representing MBs, were assessed on coronal sections at the frontal, the central and the occipital level of a cerebral hemisphere. Results Overall, cerebrovascular lesions were rare. Only white matter damage was significantly more severe in FTLD brains compared with controls ( P = 0.03). On MRI, MBs were only significantly prevalent in the deep cortical layers ( P < 0.01) and borderline increased in the middle cortical layers ( P = 0.07) of the frontal section. Conclusions Cerebrovascular lesions are rare in FTLD. The white matter damage has to be considered as part of the neurodegenerative process. MBs prevail in the frontal regions with the most severe neuronal damage and probably represent associated disruption of the blood-brain barrier. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/j.1468-1331.2012.03776.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 1355 Subjects: – SubjectFull: Neurological disorders Type: general – SubjectFull: Brain physiology Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Frontotemporal dementia Type: general – SubjectFull: Alzheimer's patients Type: general – SubjectFull: Cerebrovascular disease Type: general – SubjectFull: Diagnosis Type: general Titles: – TitleFull: Detection of microbleeds in post-mortem brains of patients with frontotemporal lobar degeneration: a 7.0-Tesla magnetic resonance imaging study with neuropathological correlates. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Reuck, J. – PersonEntity: Name: NameFull: Deramecourt, V. – PersonEntity: Name: NameFull: Cordonnier, C. – PersonEntity: Name: NameFull: Auger, F. – PersonEntity: Name: NameFull: Durieux, N. – PersonEntity: Name: NameFull: Bordet, R. – PersonEntity: Name: NameFull: Maurage, C. A. – PersonEntity: Name: NameFull: Leys, D. – PersonEntity: Name: NameFull: Pasquier, F. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2012 Type: published Y: 2012 Identifiers: – Type: issn-print Value: 13515101 Numbering: – Type: volume Value: 19 – Type: issue Value: 10 Titles: – TitleFull: European Journal of Neurology Type: main |
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