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Three-Dimensional Structures Self-Assembled from DNA Bricks.

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Title: Three-Dimensional Structures Self-Assembled from DNA Bricks. (cover story)
Authors: Yonggang Ke, Ong, Luvena L., Shih, William M., Peng Yin
Source: Science (pre-March 2025). 11/30/2012, Vol. 338 Issue 6111, p1177-1183. 7p.
Subjects: Molecular self-assembly, Molecular structure of nucleic acids, DNA synthesis, Chemistry methodology, Chemical synthesis, Biochemistry experiments, Molecular shapes
Abstract: We describe a simple and robust method to construct complex three-dimensional (3D) structures by using short synthetic DNA strands that we call "DNA bricks." In one-step annealing reactions, bricks with hundreds of distinct sequences serf-assemble into prescribed 3D shapes. Each 32-nucleotide brick is a modular component; it binds to four local neighbors and can be removed or added independently. Each 8-base pair interaction between bricks defines a voxel with dimensions of 2.5 by 2.5 by 2.7 nanometers, and a master brick collection defines a "molecular canvas" with dimensions of 10 by 10 by 10 voxels. By selecting subsets of bricks from this canvas, we constructed a panel of 102 distinct shapes exhibiting sophisticated surface features, as well as intricate interior cavities and tunnels. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Three-Dimensional Structures Self-Assembled from DNA Bricks. (cover story)
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  Data: <searchLink fieldCode="AR" term="%22Yonggang+Ke%22">Yonggang Ke</searchLink><br /><searchLink fieldCode="AR" term="%22Ong%2C+Luvena+L%2E%22">Ong, Luvena L.</searchLink><br /><searchLink fieldCode="AR" term="%22Shih%2C+William+M%2E%22">Shih, William M.</searchLink><br /><searchLink fieldCode="AR" term="%22Peng+Yin%22">Peng Yin</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 11/30/2012, Vol. 338 Issue 6111, p1177-1183. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Molecular+self-assembly%22">Molecular self-assembly</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+structure+of+nucleic+acids%22">Molecular structure of nucleic acids</searchLink><br /><searchLink fieldCode="DE" term="%22DNA+synthesis%22">DNA synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Chemistry+methodology%22">Chemistry methodology</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+synthesis%22">Chemical synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Biochemistry+experiments%22">Biochemistry experiments</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+shapes%22">Molecular shapes</searchLink>
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  Data: We describe a simple and robust method to construct complex three-dimensional (3D) structures by using short synthetic DNA strands that we call "DNA bricks." In one-step annealing reactions, bricks with hundreds of distinct sequences serf-assemble into prescribed 3D shapes. Each 32-nucleotide brick is a modular component; it binds to four local neighbors and can be removed or added independently. Each 8-base pair interaction between bricks defines a voxel with dimensions of 2.5 by 2.5 by 2.7 nanometers, and a master brick collection defines a "molecular canvas" with dimensions of 10 by 10 by 10 voxels. By selecting subsets of bricks from this canvas, we constructed a panel of 102 distinct shapes exhibiting sophisticated surface features, as well as intricate interior cavities and tunnels. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1126/science.1227268
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        Text: English
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      – SubjectFull: Molecular self-assembly
        Type: general
      – SubjectFull: Molecular structure of nucleic acids
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      – SubjectFull: DNA synthesis
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              Text: 11/30/2012
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