Three-Dimensional Structures Self-Assembled from DNA Bricks.
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| Title: | Three-Dimensional Structures Self-Assembled from DNA Bricks. (cover story) |
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| Authors: | Yonggang Ke, Ong, Luvena L., Shih, William M., Peng Yin |
| Source: | Science (pre-March 2025). 11/30/2012, Vol. 338 Issue 6111, p1177-1183. 7p. |
| Subjects: | Molecular self-assembly, Molecular structure of nucleic acids, DNA synthesis, Chemistry methodology, Chemical synthesis, Biochemistry experiments, Molecular shapes |
| Abstract: | We describe a simple and robust method to construct complex three-dimensional (3D) structures by using short synthetic DNA strands that we call "DNA bricks." In one-step annealing reactions, bricks with hundreds of distinct sequences serf-assemble into prescribed 3D shapes. Each 32-nucleotide brick is a modular component; it binds to four local neighbors and can be removed or added independently. Each 8-base pair interaction between bricks defines a voxel with dimensions of 2.5 by 2.5 by 2.7 nanometers, and a master brick collection defines a "molecular canvas" with dimensions of 10 by 10 by 10 voxels. By selecting subsets of bricks from this canvas, we constructed a panel of 102 distinct shapes exhibiting sophisticated surface features, as well as intricate interior cavities and tunnels. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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