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EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-lndependent.

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Title: EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-lndependent.
Authors: Kexin Xu, Wu, Zhenhua Jeremy, Groner, Anna C., Housheng Hansen He, Changmeng Cai, Lis, Rosina T., Xiaoqiu Wu, Stack, Edward C., Loda, Massimo, Tao Liu, Han Xu, Cato, Laura, Thornton, James E., Gregory, Richard I., Morrissey, Colm, Vessella, Robert L., Montironi, Rodolfo, Magi-Galluzzi, Cristina, Kantoff, Philip W., Balk, Steven P.
Source: Science (pre-March 2025). 12/14/2012, Vol. 338 Issue 6113, p1465-1469. 5p.
Subjects: Gene enhancers, Prostate cancer, Polycomb group protein genetics, Oncogenes, Carcinogenesis, Histone methyltransferases, Phosphorylation
Abstract: Epigenetic regulators represent a promising new class of therapeutic targets for cancer. Enhancer of zeste homolog 2 (EZH2), a subunit of Polycomb repressive complex 2 (PRC2), silences gene expression via its histone methyltransferase activity. We found that the oncogenic function of EZH2 in cells of castration-resistant prostate cancer is independent of its role as a transcriptional repressor. Instead, it involves the ability of EZH2 to act as a coactivator for critical transcription factors including the androgen receptor. This functional switch is dependent on phosphorylation of EZH2 and requires an intact methyltransferase domain. Hence, targeting the non-PRC2 function of EZH2 may have therapeutic efficacy for treating metastatic, hormone-refractory prostate cancer. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-lndependent.
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  Data: <searchLink fieldCode="AR" term="%22Kexin+Xu%22">Kexin Xu</searchLink><br /><searchLink fieldCode="AR" term="%22Wu%2C+Zhenhua+Jeremy%22">Wu, Zhenhua Jeremy</searchLink><br /><searchLink fieldCode="AR" term="%22Groner%2C+Anna+C%2E%22">Groner, Anna C.</searchLink><br /><searchLink fieldCode="AR" term="%22Housheng+Hansen+He%22">Housheng Hansen He</searchLink><br /><searchLink fieldCode="AR" term="%22Changmeng+Cai%22">Changmeng Cai</searchLink><br /><searchLink fieldCode="AR" term="%22Lis%2C+Rosina+T%2E%22">Lis, Rosina T.</searchLink><br /><searchLink fieldCode="AR" term="%22Xiaoqiu+Wu%22">Xiaoqiu Wu</searchLink><br /><searchLink fieldCode="AR" term="%22Stack%2C+Edward+C%2E%22">Stack, Edward C.</searchLink><br /><searchLink fieldCode="AR" term="%22Loda%2C+Massimo%22">Loda, Massimo</searchLink><br /><searchLink fieldCode="AR" term="%22Tao+Liu%22">Tao Liu</searchLink><br /><searchLink fieldCode="AR" term="%22Han+Xu%22">Han Xu</searchLink><br /><searchLink fieldCode="AR" term="%22Cato%2C+Laura%22">Cato, Laura</searchLink><br /><searchLink fieldCode="AR" term="%22Thornton%2C+James+E%2E%22">Thornton, James E.</searchLink><br /><searchLink fieldCode="AR" term="%22Gregory%2C+Richard+I%2E%22">Gregory, Richard I.</searchLink><br /><searchLink fieldCode="AR" term="%22Morrissey%2C+Colm%22">Morrissey, Colm</searchLink><br /><searchLink fieldCode="AR" term="%22Vessella%2C+Robert+L%2E%22">Vessella, Robert L.</searchLink><br /><searchLink fieldCode="AR" term="%22Montironi%2C+Rodolfo%22">Montironi, Rodolfo</searchLink><br /><searchLink fieldCode="AR" term="%22Magi-Galluzzi%2C+Cristina%22">Magi-Galluzzi, Cristina</searchLink><br /><searchLink fieldCode="AR" term="%22Kantoff%2C+Philip+W%2E%22">Kantoff, Philip W.</searchLink><br /><searchLink fieldCode="AR" term="%22Balk%2C+Steven+P%2E%22">Balk, Steven P.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 12/14/2012, Vol. 338 Issue 6113, p1465-1469. 5p.
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  Data: <searchLink fieldCode="DE" term="%22Gene+enhancers%22">Gene enhancers</searchLink><br /><searchLink fieldCode="DE" term="%22Prostate+cancer%22">Prostate cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Polycomb+group+protein+genetics%22">Polycomb group protein genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Oncogenes%22">Oncogenes</searchLink><br /><searchLink fieldCode="DE" term="%22Carcinogenesis%22">Carcinogenesis</searchLink><br /><searchLink fieldCode="DE" term="%22Histone+methyltransferases%22">Histone methyltransferases</searchLink><br /><searchLink fieldCode="DE" term="%22Phosphorylation%22">Phosphorylation</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Epigenetic regulators represent a promising new class of therapeutic targets for cancer. Enhancer of zeste homolog 2 (EZH2), a subunit of Polycomb repressive complex 2 (PRC2), silences gene expression via its histone methyltransferase activity. We found that the oncogenic function of EZH2 in cells of castration-resistant prostate cancer is independent of its role as a transcriptional repressor. Instead, it involves the ability of EZH2 to act as a coactivator for critical transcription factors including the androgen receptor. This functional switch is dependent on phosphorylation of EZH2 and requires an intact methyltransferase domain. Hence, targeting the non-PRC2 function of EZH2 may have therapeutic efficacy for treating metastatic, hormone-refractory prostate cancer. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=84471148
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        Value: 10.1126/science.1227604
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        Text: English
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        PageCount: 5
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      – SubjectFull: Polycomb group protein genetics
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      – SubjectFull: Histone methyltransferases
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      – SubjectFull: Phosphorylation
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