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A Steroid Receptor--MicroRNA Switch Regulates Life Span in Response to Signals from the Gonad.

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Title: A Steroid Receptor--MicroRNA Switch Regulates Life Span in Response to Signals from the Gonad.
Authors: Shen, Yidong, Wollam, Joshua, Magner, Daniel, Karalay, Oezlem, Antebi, Adam
Source: Science (pre-March 2025). 12/14/2012, Vol. 338 Issue 6113, p1472-1476. 5p.
Subjects: Gonads, MicroRNA genetics, Germ cells, Caenorhabditis elegans, Life spans, Animal life spans
Abstract: Although the gonad primarily functions in procreation, it also affects animal life span. Here, we show that removal of the Caenorhabditis elegans germ line triggers a switch in the regulatory state of the organism to promote longevity, co-opting components involved in larval developmental timing circuits. These components include the DAF-12 steroid receptor, which is involved in the larval stage two-to-stage three (L2-L3) transition and up-regulates members of the let-7 microRNA (miRNA) family. The miRNAs target an early larval nuclear factor lin-14 and akt-1/kinase, thereby stimulating DAF-16/FOXO signaling to extend life. Our studies suggest that metazoan life span is coupled to the gonad through elements of a developmental timer. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: A Steroid Receptor--MicroRNA Switch Regulates Life Span in Response to Signals from the Gonad.
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  Data: <searchLink fieldCode="AR" term="%22Shen%2C+Yidong%22">Shen, Yidong</searchLink><br /><searchLink fieldCode="AR" term="%22Wollam%2C+Joshua%22">Wollam, Joshua</searchLink><br /><searchLink fieldCode="AR" term="%22Magner%2C+Daniel%22">Magner, Daniel</searchLink><br /><searchLink fieldCode="AR" term="%22Karalay%2C+Oezlem%22">Karalay, Oezlem</searchLink><br /><searchLink fieldCode="AR" term="%22Antebi%2C+Adam%22">Antebi, Adam</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 12/14/2012, Vol. 338 Issue 6113, p1472-1476. 5p.
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  Data: <searchLink fieldCode="DE" term="%22Gonads%22">Gonads</searchLink><br /><searchLink fieldCode="DE" term="%22MicroRNA+genetics%22">MicroRNA genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Germ+cells%22">Germ cells</searchLink><br /><searchLink fieldCode="DE" term="%22Caenorhabditis+elegans%22">Caenorhabditis elegans</searchLink><br /><searchLink fieldCode="DE" term="%22Life+spans%22">Life spans</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+life+spans%22">Animal life spans</searchLink>
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  Label: Abstract
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  Data: Although the gonad primarily functions in procreation, it also affects animal life span. Here, we show that removal of the Caenorhabditis elegans germ line triggers a switch in the regulatory state of the organism to promote longevity, co-opting components involved in larval developmental timing circuits. These components include the DAF-12 steroid receptor, which is involved in the larval stage two-to-stage three (L2-L3) transition and up-regulates members of the let-7 microRNA (miRNA) family. The miRNAs target an early larval nuclear factor lin-14 and akt-1/kinase, thereby stimulating DAF-16/FOXO signaling to extend life. Our studies suggest that metazoan life span is coupled to the gonad through elements of a developmental timer. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1126/science.1228967
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      – Code: eng
        Text: English
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      – SubjectFull: MicroRNA genetics
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      – SubjectFull: Germ cells
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      – SubjectFull: Caenorhabditis elegans
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              Text: 12/14/2012
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