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The COMT Val/Met polymorphism is associated with reading-related skills and consistent patterns of functional neural activation.

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Title: The COMT Val/Met polymorphism is associated with reading-related skills and consistent patterns of functional neural activation.
Authors: Landi, Nicole, Frost, Stephen J., Mencl, W. Einar, Preston, Jonathan L., Jacobsen, Leslie K., Lee, Maria, Yrigollen, Carolyn, Pugh, Kenneth R., Grigorenko, Elena L.
Source: Developmental Science. Jan2013, Vol. 16 Issue 1, p13-23. 11p. 2 Color Photographs, 7 Charts.
Subjects: Reading disability, Intellect & genetics, Genetic polymorphisms, Reading ability testing, Valine, Physiological effects of methionine, Neural physiology
Abstract: In both children and adults there is large variability in reading skill, with approximately 5-10% of individuals characterized as having reading disability; these individuals struggle to learn to read despite adequate intelligence and opportunity. Although it is well established that a substantial portion of this variability is attributed to the genetic differences between individuals, specifics of the connections between reading and the genome are not understood. This article presents data that suggest that variation in the COMT gene, which has previously been associated with variation in higher-order cognition, is associated with reading and reading-related skills, at the level of both brain and behavior. In particular, we found that the COMT Val/Met polymorphism at rs4680, which results in the substitution of the ancestral Valine (Val) by Methionine (Met), was associated with better performance on a number of critical reading measures and with patterns of functional neural activation that have been linked to better readers. We argue that this polymorphism, known for its broad effects on cognition, may modulate (likely through frontal lobe function) reading skill. [ABSTRACT FROM AUTHOR]
Copyright of Developmental Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The COMT Val/Met polymorphism is associated with reading-related skills and consistent patterns of functional neural activation.
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  Data: <searchLink fieldCode="AR" term="%22Landi%2C+Nicole%22">Landi, Nicole</searchLink><br /><searchLink fieldCode="AR" term="%22Frost%2C+Stephen+J%2E%22">Frost, Stephen J.</searchLink><br /><searchLink fieldCode="AR" term="%22Mencl%2C+W%2E+Einar%22">Mencl, W. Einar</searchLink><br /><searchLink fieldCode="AR" term="%22Preston%2C+Jonathan+L%2E%22">Preston, Jonathan L.</searchLink><br /><searchLink fieldCode="AR" term="%22Jacobsen%2C+Leslie+K%2E%22">Jacobsen, Leslie K.</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+Maria%22">Lee, Maria</searchLink><br /><searchLink fieldCode="AR" term="%22Yrigollen%2C+Carolyn%22">Yrigollen, Carolyn</searchLink><br /><searchLink fieldCode="AR" term="%22Pugh%2C+Kenneth+R%2E%22">Pugh, Kenneth R.</searchLink><br /><searchLink fieldCode="AR" term="%22Grigorenko%2C+Elena+L%2E%22">Grigorenko, Elena L.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Developmental+Science%22">Developmental Science</searchLink>. Jan2013, Vol. 16 Issue 1, p13-23. 11p. 2 Color Photographs, 7 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Reading+disability%22">Reading disability</searchLink><br /><searchLink fieldCode="DE" term="%22Intellect+%26+genetics%22">Intellect & genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Reading+ability+testing%22">Reading ability testing</searchLink><br /><searchLink fieldCode="DE" term="%22Valine%22">Valine</searchLink><br /><searchLink fieldCode="DE" term="%22Physiological+effects+of+methionine%22">Physiological effects of methionine</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+physiology%22">Neural physiology</searchLink>
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  Data: In both children and adults there is large variability in reading skill, with approximately 5-10% of individuals characterized as having reading disability; these individuals struggle to learn to read despite adequate intelligence and opportunity. Although it is well established that a substantial portion of this variability is attributed to the genetic differences between individuals, specifics of the connections between reading and the genome are not understood. This article presents data that suggest that variation in the COMT gene, which has previously been associated with variation in higher-order cognition, is associated with reading and reading-related skills, at the level of both brain and behavior. In particular, we found that the COMT Val/Met polymorphism at rs4680, which results in the substitution of the ancestral Valine (Val) by Methionine (Met), was associated with better performance on a number of critical reading measures and with patterns of functional neural activation that have been linked to better readers. We argue that this polymorphism, known for its broad effects on cognition, may modulate (likely through frontal lobe function) reading skill. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Developmental Science is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/j.1467-7687.2012.01180.x
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      – Code: eng
        Text: English
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        PageCount: 11
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      – SubjectFull: Intellect & genetics
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      – SubjectFull: Genetic polymorphisms
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      – SubjectFull: Reading ability testing
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      – SubjectFull: Valine
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      – SubjectFull: Physiological effects of methionine
        Type: general
      – SubjectFull: Neural physiology
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      – TitleFull: The COMT Val/Met polymorphism is associated with reading-related skills and consistent patterns of functional neural activation.
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              Text: Jan2013
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