View in EDS HTML Full Text PDF Full Text

Effect of glatiramer acetate on disease reactivation in MS patients discontinuing natalizumab.

Saved in:
Bibliographic Details
Title: Effect of glatiramer acetate on disease reactivation in MS patients discontinuing natalizumab.
Authors: Rossi, S., Motta, C., Studer, V., De Chiara, V., Barbieri, F., Monteleone, F., Fornasiero, A., Coarelli, G., Bernardi, G., Cutter, G., Stüve, O., Salvetti, M., Centonze, D.
Source: European Journal of Neurology. Jan2013, Vol. 20 Issue 1, p87-94. 8p. 2 Charts, 3 Graphs.
Subjects: Multiple sclerosis, Glatiramer acetate, Immunoregulation, Natalizumab, Progressive multifocal leukoencephalopathy, Medication safety, Patients
Abstract: Background and purpose Multiple sclerosis (MS) patients discontinuing natalizumab are at risk of rebound of disease activity. Methods In the present multi-center, open-label, non-randomized, prospective, pilot study, we tested whether treatment with glatiramer acetate (GA) is safe and effective after natalizumab in MS patients. The study was performed at academic tertiary medical centers. Forty active relapsing-remitting MS patients who never failed GA therapy and who discontinued natalizumab after 12-18 months of therapy were enrolled. GA was initiated 4 weeks after the last dose of natalizumab. Results 62.5% of patients were relapse-free 12 months after GA initiation. Annualized relapse rate and time to relapse were significantly lower than before natalizumab. Notably, the frequency of relapses was significantly lower amongst those patients who had experienced ≤2 relapses the year before initiation of natalizumab therapy, compared with patients who had had three or more relapses. No evidence of rebound was observed in magnetic resonance imaging scans. Furthermore, Expanded Disability Status Scale and Multiple Sclerosis Functional Composite were stable in our patients, again suggesting that 12 months of post-natalizumab-GA therapy is not associated with clinical deterioration. Conclusions: Following discontinuation of natalizumab, 12 months of therapy with GA is safe and well tolerated in MS patients. GA can reduce the risk of early reactivation/rebound of disease activity in this setting. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 84506455
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Effect of glatiramer acetate on disease reactivation in MS patients discontinuing natalizumab.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Rossi%2C+S%2E%22">Rossi, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Motta%2C+C%2E%22">Motta, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Studer%2C+V%2E%22">Studer, V.</searchLink><br /><searchLink fieldCode="AR" term="%22De+Chiara%2C+V%2E%22">De Chiara, V.</searchLink><br /><searchLink fieldCode="AR" term="%22Barbieri%2C+F%2E%22">Barbieri, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Monteleone%2C+F%2E%22">Monteleone, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Fornasiero%2C+A%2E%22">Fornasiero, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Coarelli%2C+G%2E%22">Coarelli, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Bernardi%2C+G%2E%22">Bernardi, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Cutter%2C+G%2E%22">Cutter, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Stüve%2C+O%2E%22">Stüve, O.</searchLink><br /><searchLink fieldCode="AR" term="%22Salvetti%2C+M%2E%22">Salvetti, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Centonze%2C+D%2E%22">Centonze, D.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Jan2013, Vol. 20 Issue 1, p87-94. 8p. 2 Charts, 3 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Multiple+sclerosis%22">Multiple sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Glatiramer+acetate%22">Glatiramer acetate</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoregulation%22">Immunoregulation</searchLink><br /><searchLink fieldCode="DE" term="%22Natalizumab%22">Natalizumab</searchLink><br /><searchLink fieldCode="DE" term="%22Progressive+multifocal+leukoencephalopathy%22">Progressive multifocal leukoencephalopathy</searchLink><br /><searchLink fieldCode="DE" term="%22Medication+safety%22">Medication safety</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background and purpose Multiple sclerosis (MS) patients discontinuing natalizumab are at risk of rebound of disease activity. Methods In the present multi-center, open-label, non-randomized, prospective, pilot study, we tested whether treatment with glatiramer acetate (GA) is safe and effective after natalizumab in MS patients. The study was performed at academic tertiary medical centers. Forty active relapsing-remitting MS patients who never failed GA therapy and who discontinued natalizumab after 12-18 months of therapy were enrolled. GA was initiated 4 weeks after the last dose of natalizumab. Results 62.5% of patients were relapse-free 12 months after GA initiation. Annualized relapse rate and time to relapse were significantly lower than before natalizumab. Notably, the frequency of relapses was significantly lower amongst those patients who had experienced ≤2 relapses the year before initiation of natalizumab therapy, compared with patients who had had three or more relapses. No evidence of rebound was observed in magnetic resonance imaging scans. Furthermore, Expanded Disability Status Scale and Multiple Sclerosis Functional Composite were stable in our patients, again suggesting that 12 months of post-natalizumab-GA therapy is not associated with clinical deterioration. Conclusions: Following discontinuation of natalizumab, 12 months of therapy with GA is safe and well tolerated in MS patients. GA can reduce the risk of early reactivation/rebound of disease activity in this setting. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=84506455
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/j.1468-1331.2012.03794.x
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 87
    Subjects:
      – SubjectFull: Multiple sclerosis
        Type: general
      – SubjectFull: Glatiramer acetate
        Type: general
      – SubjectFull: Immunoregulation
        Type: general
      – SubjectFull: Natalizumab
        Type: general
      – SubjectFull: Progressive multifocal leukoencephalopathy
        Type: general
      – SubjectFull: Medication safety
        Type: general
      – SubjectFull: Patients
        Type: general
    Titles:
      – TitleFull: Effect of glatiramer acetate on disease reactivation in MS patients discontinuing natalizumab.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Rossi, S.
      – PersonEntity:
          Name:
            NameFull: Motta, C.
      – PersonEntity:
          Name:
            NameFull: Studer, V.
      – PersonEntity:
          Name:
            NameFull: De Chiara, V.
      – PersonEntity:
          Name:
            NameFull: Barbieri, F.
      – PersonEntity:
          Name:
            NameFull: Monteleone, F.
      – PersonEntity:
          Name:
            NameFull: Fornasiero, A.
      – PersonEntity:
          Name:
            NameFull: Coarelli, G.
      – PersonEntity:
          Name:
            NameFull: Bernardi, G.
      – PersonEntity:
          Name:
            NameFull: Cutter, G.
      – PersonEntity:
          Name:
            NameFull: Stüve, O.
      – PersonEntity:
          Name:
            NameFull: Salvetti, M.
      – PersonEntity:
          Name:
            NameFull: Centonze, D.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Text: Jan2013
              Type: published
              Y: 2013
          Identifiers:
            – Type: issn-print
              Value: 13515101
          Numbering:
            – Type: volume
              Value: 20
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: European Journal of Neurology
              Type: main
ResultId 1