Cerebral small vessel disease in aging and Alzheimer's disease: a comparative study using MRI and SPECT.
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| Title: | Cerebral small vessel disease in aging and Alzheimer's disease: a comparative study using MRI and SPECT. |
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| Authors: | Makedonov, I., Black, S. E., MacIntosh, B. J. |
| Source: | European Journal of Neurology. Feb2013, Vol. 20 Issue 2, p243-250. 8p. 1 Color Photograph, 1 Chart, 3 Graphs. |
| Subjects: | Aging, Alzheimer's disease, Magnetic resonance imaging, Photon emission, Tomography |
| Abstract: | Background White matter hyperintensities ( WMH) are associated with aging and are prevalent in various brain pathologies. The purpose of the current study was to characterize WMH perfusion in age-matched elderly controls ( ECs) and patients with Alzheimer's disease ( ADs). Methods Fifty ECs (23 men) and 61 ADs (33 men) underwent magnetic resonance imaging ( MRI), 99m Tc- ECD single-photon emission computed tomography ( SPECT) and cognitive testing. Brain tissue type was classified on T1 weighted images, and WMH were identified on interleaved proton density/ T2 weighted images. Co-registered MR images were used to characterize SPECT perfusion patterns. Results WMH perfusion was lower than normal appearing white matter ( NAWM) perfusion ( P < 0.001) in both EC and AD groups. There was no WMH perfusion difference between groups when considering the mean perfusion from all WMH voxels ( P > 0.43). However, locations that were likely to be considered WMH tended to have lower perfusion in ADs compared with ECs. Perfusion gradients along watershed white matter regions were significantly different between EC and AD groups ( P < 0.05). A relationship was found between the volume of a WMH lesion and its mean perfusion ( P < 0.001) in both ECs and ADs. Conclusion Global WMH were hypoperfused compared with NAWM to the same degree in EC and AD participants, which suggests a common WMH etiology between groups. However, white matter locations that were likely to contain WMH tended to be hypoperfused in ADs compared with healthy aging. This finding is suggestive of AD-specific pathology that reduces the perfusion at anatomic locations susceptible to the formation of WMH through either the neurodegenerative process or AD-related vasculopathy or both. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 84740689 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Cerebral small vessel disease in aging and Alzheimer's disease: a comparative study using MRI and SPECT. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Makedonov%2C+I%2E%22">Makedonov, I.</searchLink><br /><searchLink fieldCode="AR" term="%22Black%2C+S%2E+E%2E%22">Black, S. E.</searchLink><br /><searchLink fieldCode="AR" term="%22MacIntosh%2C+B%2E+J%2E%22">MacIntosh, B. J.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Feb2013, Vol. 20 Issue 2, p243-250. 8p. 1 Color Photograph, 1 Chart, 3 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Aging%22">Aging</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Photon+emission%22">Photon emission</searchLink><br /><searchLink fieldCode="DE" term="%22Tomography%22">Tomography</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background White matter hyperintensities ( WMH) are associated with aging and are prevalent in various brain pathologies. The purpose of the current study was to characterize WMH perfusion in age-matched elderly controls ( ECs) and patients with Alzheimer's disease ( ADs). Methods Fifty ECs (23 men) and 61 ADs (33 men) underwent magnetic resonance imaging ( MRI), 99m Tc- ECD single-photon emission computed tomography ( SPECT) and cognitive testing. Brain tissue type was classified on T1 weighted images, and WMH were identified on interleaved proton density/ T2 weighted images. Co-registered MR images were used to characterize SPECT perfusion patterns. Results WMH perfusion was lower than normal appearing white matter ( NAWM) perfusion ( P < 0.001) in both EC and AD groups. There was no WMH perfusion difference between groups when considering the mean perfusion from all WMH voxels ( P > 0.43). However, locations that were likely to be considered WMH tended to have lower perfusion in ADs compared with ECs. Perfusion gradients along watershed white matter regions were significantly different between EC and AD groups ( P < 0.05). A relationship was found between the volume of a WMH lesion and its mean perfusion ( P < 0.001) in both ECs and ADs. Conclusion Global WMH were hypoperfused compared with NAWM to the same degree in EC and AD participants, which suggests a common WMH etiology between groups. However, white matter locations that were likely to contain WMH tended to be hypoperfused in ADs compared with healthy aging. This finding is suggestive of AD-specific pathology that reduces the perfusion at anatomic locations susceptible to the formation of WMH through either the neurodegenerative process or AD-related vasculopathy or both. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/j.1468-1331.2012.03785.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 243 Subjects: – SubjectFull: Aging Type: general – SubjectFull: Alzheimer's disease Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Photon emission Type: general – SubjectFull: Tomography Type: general Titles: – TitleFull: Cerebral small vessel disease in aging and Alzheimer's disease: a comparative study using MRI and SPECT. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Makedonov, I. – PersonEntity: Name: NameFull: Black, S. E. – PersonEntity: Name: NameFull: MacIntosh, B. J. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 13515101 Numbering: – Type: volume Value: 20 – Type: issue Value: 2 Titles: – TitleFull: European Journal of Neurology Type: main |
| ResultId | 1 |
