Amine oxidase activity of β-amyloid precursor protein modulates systemic and local catecholamine levels.
Saved in:
| Title: | Amine oxidase activity of β-amyloid precursor protein modulates systemic and local catecholamine levels. |
|---|---|
| Authors: | Duce, J A, Ayton, S, Miller, A A, Tsatsanis, A, Lam, L Q, Leone, L, Corbin, J E, Butzkueven, H, Kilpatrick, T J, Rogers, J T, Barnham, K J, Finkelstein, D I, Bush, A I |
| Source: | Molecular Psychiatry. Feb2013, Vol. 18 Issue 2, p245-254. 10p. 5 Graphs. |
| Subjects: | Catecholamines, Amyloid beta-protein, Neurotransmitters, Carrier proteins, Ceruloplasmin |
| Abstract: | The catecholamines dopamine (DA), norepinephrine (NE) and epinephrine (E) are neurotransmitters and hormones that mediate stress responses in tissues and plasma. The expression of β-amyloid precursor protein (APP) is responsive to stress and is high in tissues rich in catecholamines. We recently reported that APP is a ferroxidase, subsuming, in neurons and other cells, the iron-export activity that ceruloplasmin mediates in glia. Here we report that, like ceruloplasmin, APP also oxidizes synthetic amines and catecholamines catalytically (Km NE=0.27 mM), through a site encompassing its ferroxidase motif and selectively inhibited by zinc. Accordingly, APP knockout mice have significantly higher levels of DA, NE and E in brain, plasma and select tissues. Consistent with this, these animals have increased resting heart rate and systolic blood pressure as well as suppressed prolactin and lymphocyte levels. These findings support a role for APP in extracellular catecholaminergic clearance. [ABSTRACT FROM AUTHOR] |
| Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 85039038 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Amine oxidase activity of β-amyloid precursor protein modulates systemic and local catecholamine levels. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Duce%2C+J+A%22">Duce, J A</searchLink><br /><searchLink fieldCode="AR" term="%22Ayton%2C+S%22">Ayton, S</searchLink><br /><searchLink fieldCode="AR" term="%22Miller%2C+A+A%22">Miller, A A</searchLink><br /><searchLink fieldCode="AR" term="%22Tsatsanis%2C+A%22">Tsatsanis, A</searchLink><br /><searchLink fieldCode="AR" term="%22Lam%2C+L+Q%22">Lam, L Q</searchLink><br /><searchLink fieldCode="AR" term="%22Leone%2C+L%22">Leone, L</searchLink><br /><searchLink fieldCode="AR" term="%22Corbin%2C+J+E%22">Corbin, J E</searchLink><br /><searchLink fieldCode="AR" term="%22Butzkueven%2C+H%22">Butzkueven, H</searchLink><br /><searchLink fieldCode="AR" term="%22Kilpatrick%2C+T+J%22">Kilpatrick, T J</searchLink><br /><searchLink fieldCode="AR" term="%22Rogers%2C+J+T%22">Rogers, J T</searchLink><br /><searchLink fieldCode="AR" term="%22Barnham%2C+K+J%22">Barnham, K J</searchLink><br /><searchLink fieldCode="AR" term="%22Finkelstein%2C+D+I%22">Finkelstein, D I</searchLink><br /><searchLink fieldCode="AR" term="%22Bush%2C+A+I%22">Bush, A I</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Molecular+Psychiatry%22">Molecular Psychiatry</searchLink>. Feb2013, Vol. 18 Issue 2, p245-254. 10p. 5 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Catecholamines%22">Catecholamines</searchLink><br /><searchLink fieldCode="DE" term="%22Amyloid+beta-protein%22">Amyloid beta-protein</searchLink><br /><searchLink fieldCode="DE" term="%22Neurotransmitters%22">Neurotransmitters</searchLink><br /><searchLink fieldCode="DE" term="%22Carrier+proteins%22">Carrier proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Ceruloplasmin%22">Ceruloplasmin</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The catecholamines dopamine (DA), norepinephrine (NE) and epinephrine (E) are neurotransmitters and hormones that mediate stress responses in tissues and plasma. The expression of β-amyloid precursor protein (APP) is responsive to stress and is high in tissues rich in catecholamines. We recently reported that APP is a ferroxidase, subsuming, in neurons and other cells, the iron-export activity that ceruloplasmin mediates in glia. Here we report that, like ceruloplasmin, APP also oxidizes synthetic amines and catecholamines catalytically (Km NE=0.27 mM), through a site encompassing its ferroxidase motif and selectively inhibited by zinc. Accordingly, APP knockout mice have significantly higher levels of DA, NE and E in brain, plasma and select tissues. Consistent with this, these animals have increased resting heart rate and systolic blood pressure as well as suppressed prolactin and lymphocyte levels. These findings support a role for APP in extracellular catecholaminergic clearance. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=85039038 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/mp.2011.168 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 245 Subjects: – SubjectFull: Catecholamines Type: general – SubjectFull: Amyloid beta-protein Type: general – SubjectFull: Neurotransmitters Type: general – SubjectFull: Carrier proteins Type: general – SubjectFull: Ceruloplasmin Type: general Titles: – TitleFull: Amine oxidase activity of β-amyloid precursor protein modulates systemic and local catecholamine levels. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Duce, J A – PersonEntity: Name: NameFull: Ayton, S – PersonEntity: Name: NameFull: Miller, A A – PersonEntity: Name: NameFull: Tsatsanis, A – PersonEntity: Name: NameFull: Lam, L Q – PersonEntity: Name: NameFull: Leone, L – PersonEntity: Name: NameFull: Corbin, J E – PersonEntity: Name: NameFull: Butzkueven, H – PersonEntity: Name: NameFull: Kilpatrick, T J – PersonEntity: Name: NameFull: Rogers, J T – PersonEntity: Name: NameFull: Barnham, K J – PersonEntity: Name: NameFull: Finkelstein, D I – PersonEntity: Name: NameFull: Bush, A I IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 13594184 Numbering: – Type: volume Value: 18 – Type: issue Value: 2 Titles: – TitleFull: Molecular Psychiatry Type: main |
| ResultId | 1 |
