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Impaired response to hypoxia in the respiratory center is a major cause of neonatal death of the PACAP-knockout mouse.

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Title: Impaired response to hypoxia in the respiratory center is a major cause of neonatal death of the PACAP-knockout mouse.
Authors: Arata, Satoru, Nakamachi, Tomoya, Onimaru, Hiroshi, Hashimoto, Hitoshi, Shioda, Seiji
Source: European Journal of Neuroscience. Feb2013, Vol. 37 Issue 3, p407-416. 10p.
Subjects: Hypoxemia, Pituitary adenylate cyclase activating polypeptide, Neonatal death, Knockout mice, Neuropeptides, Gene expression
Abstract: Pituitary adenylate cyclase-activating polypeptide ( PACAP) is a neuropeptide expressed widely in nervous tissues. PACAP-knockout (−/−) mice display a sudden infant death syndrome ( SIDS)-like phenotype, although the underlying physiological mechanism to explain this remains unclear. Here, we report on the presence of abnormal respiratory activity in PACAP−/− mice under hypoxic conditions, which provides a basis for the SIDS-like phenotype. PACAP−/− mice display a lowered baseline respiratory activity compared with wild-type animals, and an abnormal response to hypoxia. More specifically, PACAP−/− mice at postnatal day 7 showed respiratory arrest in response to hypoxia. In contrast, their response to hypercapnic conditions was the same as that of wild-type mice. Histological and real-time PCR analyses indicated that the catecholaminergic system in the medulla oblongata was impaired in PACAP−/− mice, suggesting that endogenous PACAP affects respiratory centers in the medulla oblongata via its action on the catecholaminergic system. We propose that disruption of this system is involved in the SIDS-like phenotype of PACAP−/− mice. Thus, disorders of the catecholaminergic system involved with O2 sensing could be implicated in underlying neuronal mechanisms responsible for SIDS. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Impaired response to hypoxia in the respiratory center is a major cause of neonatal death of the PACAP-knockout mouse.
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  Data: <searchLink fieldCode="AR" term="%22Arata%2C+Satoru%22">Arata, Satoru</searchLink><br /><searchLink fieldCode="AR" term="%22Nakamachi%2C+Tomoya%22">Nakamachi, Tomoya</searchLink><br /><searchLink fieldCode="AR" term="%22Onimaru%2C+Hiroshi%22">Onimaru, Hiroshi</searchLink><br /><searchLink fieldCode="AR" term="%22Hashimoto%2C+Hitoshi%22">Hashimoto, Hitoshi</searchLink><br /><searchLink fieldCode="AR" term="%22Shioda%2C+Seiji%22">Shioda, Seiji</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Feb2013, Vol. 37 Issue 3, p407-416. 10p.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Hypoxemia%22">Hypoxemia</searchLink><br /><searchLink fieldCode="DE" term="%22Pituitary+adenylate+cyclase+activating+polypeptide%22">Pituitary adenylate cyclase activating polypeptide</searchLink><br /><searchLink fieldCode="DE" term="%22Neonatal+death%22">Neonatal death</searchLink><br /><searchLink fieldCode="DE" term="%22Knockout+mice%22">Knockout mice</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropeptides%22">Neuropeptides</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Pituitary adenylate cyclase-activating polypeptide ( PACAP) is a neuropeptide expressed widely in nervous tissues. PACAP-knockout (−/−) mice display a sudden infant death syndrome ( SIDS)-like phenotype, although the underlying physiological mechanism to explain this remains unclear. Here, we report on the presence of abnormal respiratory activity in PACAP−/− mice under hypoxic conditions, which provides a basis for the SIDS-like phenotype. PACAP−/− mice display a lowered baseline respiratory activity compared with wild-type animals, and an abnormal response to hypoxia. More specifically, PACAP−/− mice at postnatal day 7 showed respiratory arrest in response to hypoxia. In contrast, their response to hypercapnic conditions was the same as that of wild-type mice. Histological and real-time PCR analyses indicated that the catecholaminergic system in the medulla oblongata was impaired in PACAP−/− mice, suggesting that endogenous PACAP affects respiratory centers in the medulla oblongata via its action on the catecholaminergic system. We propose that disruption of this system is involved in the SIDS-like phenotype of PACAP−/− mice. Thus, disorders of the catecholaminergic system involved with O2 sensing could be implicated in underlying neuronal mechanisms responsible for SIDS. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=85280665
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        Value: 10.1111/ejn.12054
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        Text: English
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      – SubjectFull: Hypoxemia
        Type: general
      – SubjectFull: Pituitary adenylate cyclase activating polypeptide
        Type: general
      – SubjectFull: Neonatal death
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      – SubjectFull: Knockout mice
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      – SubjectFull: Gene expression
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      – TitleFull: Impaired response to hypoxia in the respiratory center is a major cause of neonatal death of the PACAP-knockout mouse.
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              Text: Feb2013
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              Y: 2013
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