Modulation of neuronal plasticity following chronic concomitant administration of the novel antipsychotic lurasidone with the mood stabilizer valproic acid.
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| Title: | Modulation of neuronal plasticity following chronic concomitant administration of the novel antipsychotic lurasidone with the mood stabilizer valproic acid. |
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| Authors: | Calabrese, F., Luoni, A., Guidotti, G., Racagni, G., Fumagalli, F., Riva, M. |
| Source: | Psychopharmacology. Mar2013, Vol. 226 Issue 1, p101-112. 12p. 1 Black and White Photograph, 2 Charts, 5 Graphs. |
| Subjects: | Neuroplasticity, Drug administration, Antipsychotic agents, Mood stabilizers, Valproic acid, Epigenetics, Drug interactions |
| Abstract: | Rationale: Combinatory therapy is widely used in psychiatry owing to the possibility that drugs with different mechanisms of action may synergize to improve functions deteriorated in schizophrenia, bipolar disorders, and major depression. While combinatory strategies rely on receptor and synaptic mechanisms, it should also be considered that two drugs may also 'interact' on the long-term to determine more robust changes in neuronal plasticity, which represents a downstream target important for functional recovery. Objective: The aim of the study is to investigate neuroadaptive changes set in motion by chronic concomitant administration of the novel antipsychotic lurasidone and the mood stabilizer valproate. Methods: Animals were chronically treated with lurasidone, valproate, or the combination of the two drugs and killed 24 h after the last injection to evaluate alterations of different measures of neuronal plasticity such as the neurotrophin brain-derived neurotrophic factor (BDNF), the immediate early gene Activity-regulated cytoskeletal associated protein, and the epigenetic regulators HDAC 1, 2, and 5 in dorsal and ventral hippocampus. Results: The results suggest that coadministration of lurasidone and valproate produces, when compared to the single drugs, a larger increase in the expression of BDNF in the ventral hippocampus, through the regulation of specific neurotrophin transcripts. We also found that the histone deacetylases were regulated by the drug combination, suggesting that some of the transcriptional changes may be sustained by epigenetic mechanisms. Conclusions: Our results suggest that the beneficial effects associated with combinatory treatment between a second-generation antipsychotic and a mood stabilizer could result from the ability to modulate neuroplastic molecules, whose expression and function is deteriorated in different psychiatric conditions. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 85434378 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Modulation of neuronal plasticity following chronic concomitant administration of the novel antipsychotic lurasidone with the mood stabilizer valproic acid. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Calabrese%2C+F%2E%22">Calabrese, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Luoni%2C+A%2E%22">Luoni, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Guidotti%2C+G%2E%22">Guidotti, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Racagni%2C+G%2E%22">Racagni, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Fumagalli%2C+F%2E%22">Fumagalli, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Riva%2C+M%2E%22">Riva, M.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Mar2013, Vol. 226 Issue 1, p101-112. 12p. 1 Black and White Photograph, 2 Charts, 5 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Neuroplasticity%22">Neuroplasticity</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+administration%22">Drug administration</searchLink><br /><searchLink fieldCode="DE" term="%22Antipsychotic+agents%22">Antipsychotic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Mood+stabilizers%22">Mood stabilizers</searchLink><br /><searchLink fieldCode="DE" term="%22Valproic+acid%22">Valproic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Epigenetics%22">Epigenetics</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+interactions%22">Drug interactions</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rationale: Combinatory therapy is widely used in psychiatry owing to the possibility that drugs with different mechanisms of action may synergize to improve functions deteriorated in schizophrenia, bipolar disorders, and major depression. While combinatory strategies rely on receptor and synaptic mechanisms, it should also be considered that two drugs may also 'interact' on the long-term to determine more robust changes in neuronal plasticity, which represents a downstream target important for functional recovery. Objective: The aim of the study is to investigate neuroadaptive changes set in motion by chronic concomitant administration of the novel antipsychotic lurasidone and the mood stabilizer valproate. Methods: Animals were chronically treated with lurasidone, valproate, or the combination of the two drugs and killed 24 h after the last injection to evaluate alterations of different measures of neuronal plasticity such as the neurotrophin brain-derived neurotrophic factor (BDNF), the immediate early gene Activity-regulated cytoskeletal associated protein, and the epigenetic regulators HDAC 1, 2, and 5 in dorsal and ventral hippocampus. Results: The results suggest that coadministration of lurasidone and valproate produces, when compared to the single drugs, a larger increase in the expression of BDNF in the ventral hippocampus, through the regulation of specific neurotrophin transcripts. We also found that the histone deacetylases were regulated by the drug combination, suggesting that some of the transcriptional changes may be sustained by epigenetic mechanisms. Conclusions: Our results suggest that the beneficial effects associated with combinatory treatment between a second-generation antipsychotic and a mood stabilizer could result from the ability to modulate neuroplastic molecules, whose expression and function is deteriorated in different psychiatric conditions. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-012-2900-0 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 101 Subjects: – SubjectFull: Neuroplasticity Type: general – SubjectFull: Drug administration Type: general – SubjectFull: Antipsychotic agents Type: general – SubjectFull: Mood stabilizers Type: general – SubjectFull: Valproic acid Type: general – SubjectFull: Epigenetics Type: general – SubjectFull: Drug interactions Type: general Titles: – TitleFull: Modulation of neuronal plasticity following chronic concomitant administration of the novel antipsychotic lurasidone with the mood stabilizer valproic acid. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Calabrese, F. – PersonEntity: Name: NameFull: Luoni, A. – PersonEntity: Name: NameFull: Guidotti, G. – PersonEntity: Name: NameFull: Racagni, G. – PersonEntity: Name: NameFull: Fumagalli, F. – PersonEntity: Name: NameFull: Riva, M. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 226 – Type: issue Value: 1 Titles: – TitleFull: Psychopharmacology Type: main |
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