The serotonin 1A receptor gene confer susceptibility to mood disorders: results from an extended meta-analysis of patients with major depression and bipolar disorder.
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| Title: | The serotonin 1A receptor gene confer susceptibility to mood disorders: results from an extended meta-analysis of patients with major depression and bipolar disorder. |
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| Authors: | Kishi, Taro, Yoshimura, Reiji, Fukuo, Yasuhisa, Okochi, Tomo, Matsunaga, Shinji, Umene-Nakano, Wakako, Nakamura, Jun, Serretti, Alessandro, Correll, Christoph, Kane, John, Iwata, Nakao |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Mar2013, Vol. 263 Issue 2, p105-118. 14p. 8 Charts. |
| Subjects: | Serotonin receptors, Disease susceptibility, Affective disorders, Meta-analysis, Depressed persons, People with bipolar disorder, Gene expression |
| Abstract: | The serotonin 1A receptor gene ( HTR1A) has been associated with mood disorders (MDs), including major depressive disorder (MDD) and bipolar disorder (BP). Therefore, we conducted a systematic review and meta-analysis between rs6295 (C-1019G) as well as rs878567 in HTR1A and MDs. Searching PubMed through May 2012, 15 studies, including our own, previously unpublished association study (135 MDD patients and 107 healthy controls), met inclusion criteria for the meta-analysis of rs6295 (4,297 MDs patients and 5,435 controls). Five association studies met criteria for the meta-analysis of rs878567 (2041MDs patients and 2,734 controls). rs6295 was associated with combined MDs ( P = 0.007 and P = 0.01). When divided by diagnostic subgroup (MDD = 3,119 patients and 4,380 controls or BP = 1,170 patients and 2,252 controls), rs6295 was associated with each MDs separately (MDD: P = 0.006, P = 0.01; BP: P = 0.003). Likewise, rs878567 was associated with combined MDs (2,041 patients and 2,734 controls ( P = 0.0002, P = 0.0008, and P = 0.01). When divided by diagnostic subgroup (MDD = 1,013 patients and 1,728 controls or BP = 1,051 patients and 2,099 controls), rs878567 was associated with MDD ( P = 0.0007 and P = 0.01), while only one BP study had such data, precluding a meta-analysis. All of these significances survived correction for multiple comparisons. Results from this expanded meta-analysis, which included our own new study, suggest that rs6295 (C-1019G) and rs878567 in HTR1A are related to the pathophysiology of MDs, with overlap between MDD and BP. Findings provide additional clues to the underlying biology and treatment targets in MDs. [ABSTRACT FROM AUTHOR] |
| Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 85859895 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The serotonin 1A receptor gene confer susceptibility to mood disorders: results from an extended meta-analysis of patients with major depression and bipolar disorder. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kishi%2C+Taro%22">Kishi, Taro</searchLink><br /><searchLink fieldCode="AR" term="%22Yoshimura%2C+Reiji%22">Yoshimura, Reiji</searchLink><br /><searchLink fieldCode="AR" term="%22Fukuo%2C+Yasuhisa%22">Fukuo, Yasuhisa</searchLink><br /><searchLink fieldCode="AR" term="%22Okochi%2C+Tomo%22">Okochi, Tomo</searchLink><br /><searchLink fieldCode="AR" term="%22Matsunaga%2C+Shinji%22">Matsunaga, Shinji</searchLink><br /><searchLink fieldCode="AR" term="%22Umene-Nakano%2C+Wakako%22">Umene-Nakano, Wakako</searchLink><br /><searchLink fieldCode="AR" term="%22Nakamura%2C+Jun%22">Nakamura, Jun</searchLink><br /><searchLink fieldCode="AR" term="%22Serretti%2C+Alessandro%22">Serretti, Alessandro</searchLink><br /><searchLink fieldCode="AR" term="%22Correll%2C+Christoph%22">Correll, Christoph</searchLink><br /><searchLink fieldCode="AR" term="%22Kane%2C+John%22">Kane, John</searchLink><br /><searchLink fieldCode="AR" term="%22Iwata%2C+Nakao%22">Iwata, Nakao</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Mar2013, Vol. 263 Issue 2, p105-118. 14p. 8 Charts. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Serotonin+receptors%22">Serotonin receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+susceptibility%22">Disease susceptibility</searchLink><br /><searchLink fieldCode="DE" term="%22Affective+disorders%22">Affective disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Meta-analysis%22">Meta-analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Depressed+persons%22">Depressed persons</searchLink><br /><searchLink fieldCode="DE" term="%22People+with+bipolar+disorder%22">People with bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The serotonin 1A receptor gene ( HTR1A) has been associated with mood disorders (MDs), including major depressive disorder (MDD) and bipolar disorder (BP). Therefore, we conducted a systematic review and meta-analysis between rs6295 (C-1019G) as well as rs878567 in HTR1A and MDs. Searching PubMed through May 2012, 15 studies, including our own, previously unpublished association study (135 MDD patients and 107 healthy controls), met inclusion criteria for the meta-analysis of rs6295 (4,297 MDs patients and 5,435 controls). Five association studies met criteria for the meta-analysis of rs878567 (2041MDs patients and 2,734 controls). rs6295 was associated with combined MDs ( P = 0.007 and P = 0.01). When divided by diagnostic subgroup (MDD = 3,119 patients and 4,380 controls or BP = 1,170 patients and 2,252 controls), rs6295 was associated with each MDs separately (MDD: P = 0.006, P = 0.01; BP: P = 0.003). Likewise, rs878567 was associated with combined MDs (2,041 patients and 2,734 controls ( P = 0.0002, P = 0.0008, and P = 0.01). When divided by diagnostic subgroup (MDD = 1,013 patients and 1,728 controls or BP = 1,051 patients and 2,099 controls), rs878567 was associated with MDD ( P = 0.0007 and P = 0.01), while only one BP study had such data, precluding a meta-analysis. All of these significances survived correction for multiple comparisons. Results from this expanded meta-analysis, which included our own new study, suggest that rs6295 (C-1019G) and rs878567 in HTR1A are related to the pathophysiology of MDs, with overlap between MDD and BP. Findings provide additional clues to the underlying biology and treatment targets in MDs. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00406-012-0337-4 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 105 Subjects: – SubjectFull: Serotonin receptors Type: general – SubjectFull: Disease susceptibility Type: general – SubjectFull: Affective disorders Type: general – SubjectFull: Meta-analysis Type: general – SubjectFull: Depressed persons Type: general – SubjectFull: People with bipolar disorder Type: general – SubjectFull: Gene expression Type: general Titles: – TitleFull: The serotonin 1A receptor gene confer susceptibility to mood disorders: results from an extended meta-analysis of patients with major depression and bipolar disorder. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kishi, Taro – PersonEntity: Name: NameFull: Yoshimura, Reiji – PersonEntity: Name: NameFull: Fukuo, Yasuhisa – PersonEntity: Name: NameFull: Okochi, Tomo – PersonEntity: Name: NameFull: Matsunaga, Shinji – PersonEntity: Name: NameFull: Umene-Nakano, Wakako – PersonEntity: Name: NameFull: Nakamura, Jun – PersonEntity: Name: NameFull: Serretti, Alessandro – PersonEntity: Name: NameFull: Correll, Christoph – PersonEntity: Name: NameFull: Kane, John – PersonEntity: Name: NameFull: Iwata, Nakao IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 09401334 Numbering: – Type: volume Value: 263 – Type: issue Value: 2 Titles: – TitleFull: European Archives of Psychiatry & Clinical Neuroscience Type: main |
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