Multiple forms of synaptic plasticity triggered by selective suppression of activity in individual neurons.
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| Title: | Multiple forms of synaptic plasticity triggered by selective suppression of activity in individual neurons. |
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| Authors: | Burrone, Juan, O'Byrne, Michael, Murthy, Venkatesh N. |
| Source: | Nature. 11/28/2002, Vol. 420 Issue 6914, p414. 5p. |
| Subjects: | Neuroplasticity, Neurons |
| Abstract: | The rules by which neuronal activity causes long-term modification of synapses in the central nervous system are not fully understood. Whereas competitive or correlation-based rules result in local modification of synapses, homeostatic modifications allow neuron-wide changes in synaptic strength, promoting stability. Experimental investigations of these rules at central nervous system synapses have relied generally on manipulating activity in populations of neurons. Here, we investigated the effect of suppressing excitability in single neurons within a network of active hippocampal neurons by overexpressing an inward-rectifier potassium channel. Reducing activity in a neuron before synapse formation leads to a reduction in functional synaptic inputs to that neuron; no such reduction was observed when activity of all neurons was uniformly suppressed. In contrast, suppressing activity in a single neuron after synapses are established results in a homeostatic increase in synaptic input, which restores the activity of the neuron to control levels. Our results highlight the differences between global and selective suppression of activity, as well as those between early and late manipulation of activity. [ABSTRACT FROM AUTHOR] |
| Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 8594782 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Multiple forms of synaptic plasticity triggered by selective suppression of activity in individual neurons. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Burrone%2C+Juan%22">Burrone, Juan</searchLink><br /><searchLink fieldCode="AR" term="%22O'Byrne%2C+Michael%22">O'Byrne, Michael</searchLink><br /><searchLink fieldCode="AR" term="%22Murthy%2C+Venkatesh+N%2E%22">Murthy, Venkatesh N.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nature%22">Nature</searchLink>. 11/28/2002, Vol. 420 Issue 6914, p414. 5p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Neuroplasticity%22">Neuroplasticity</searchLink><br /><searchLink fieldCode="DE" term="%22Neurons%22">Neurons</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The rules by which neuronal activity causes long-term modification of synapses in the central nervous system are not fully understood. Whereas competitive or correlation-based rules result in local modification of synapses, homeostatic modifications allow neuron-wide changes in synaptic strength, promoting stability. Experimental investigations of these rules at central nervous system synapses have relied generally on manipulating activity in populations of neurons. Here, we investigated the effect of suppressing excitability in single neurons within a network of active hippocampal neurons by overexpressing an inward-rectifier potassium channel. Reducing activity in a neuron before synapse formation leads to a reduction in functional synaptic inputs to that neuron; no such reduction was observed when activity of all neurons was uniformly suppressed. In contrast, suppressing activity in a single neuron after synapses are established results in a homeostatic increase in synaptic input, which restores the activity of the neuron to control levels. Our results highlight the differences between global and selective suppression of activity, as well as those between early and late manipulation of activity. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/nature01242 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 414 Subjects: – SubjectFull: Neuroplasticity Type: general – SubjectFull: Neurons Type: general Titles: – TitleFull: Multiple forms of synaptic plasticity triggered by selective suppression of activity in individual neurons. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Burrone, Juan – PersonEntity: Name: NameFull: O'Byrne, Michael – PersonEntity: Name: NameFull: Murthy, Venkatesh N. IsPartOfRelationships: – BibEntity: Dates: – D: 28 M: 11 Text: 11/28/2002 Type: published Y: 2002 Identifiers: – Type: issn-print Value: 00280836 Numbering: – Type: volume Value: 420 – Type: issue Value: 6914 Titles: – TitleFull: Nature Type: main |
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