Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7, KLF4, AKT1, and SMO.
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| Title: | Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7, KLF4, AKT1, and SMO. |
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| Authors: | Clark, Victoria E., Erson-Omay, E. Zeynep, Caglayan, Ahmet Okay, Sencar, Leman, Serin, Akdes, Ceyhun, Emre, Atik, A. Fatih, Bayri, Yaşar, Bai, Hanwen, Kolb, Luis E., Hebert, Ryan M., Omay, S. Bulent, Yilmaz, Saliha, Mishra-Gorur, Ketu, Choi, Murim, Overton, John D., Jun Yin, Holland, Eric C., Mane, Shrikant, State, Matthew W. |
| Source: | Science (pre-March 2025). 3/1/2013, Vol. 339 Issue 6123, p1077-1080. 4p. |
| Subjects: | Meningioma, Genetic mutation, Brain tumors, Transcription factors, Genomics, Genetic research, Gene therapy |
| Abstract: | The article discusses a report of a genomic analysis of 300 meningiomas, the most common form of primary brain tumors, with information on the discovery of genetic mutations in the proapoptotic E3 ubiquitin ligase TRAF7. Topics include the rate of prevalence for mutations in TRAF7; concurrent mutations in the KLF4 transcription factor which plays a part in inducing pluripotency; and the rate of mutation in the AKT1 and the SMO genes in non-NF2 mutant meningiomas. A comparison of non-NF2 and mutant NF2 meningiomas is presented, with information on targeted therapeutics for meningioma subtypes. |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 86140770 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7, KLF4, AKT1, and SMO. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Clark%2C+Victoria+E%2E%22">Clark, Victoria E.</searchLink><br /><searchLink fieldCode="AR" term="%22Erson-Omay%2C+E%2E+Zeynep%22">Erson-Omay, E. Zeynep</searchLink><br /><searchLink fieldCode="AR" term="%22Caglayan%2C+Ahmet+Okay%22">Caglayan, Ahmet Okay</searchLink><br /><searchLink fieldCode="AR" term="%22Sencar%2C+Leman%22">Sencar, Leman</searchLink><br /><searchLink fieldCode="AR" term="%22Serin%2C+Akdes%22">Serin, Akdes</searchLink><br /><searchLink fieldCode="AR" term="%22Ceyhun%2C+Emre%22">Ceyhun, Emre</searchLink><br /><searchLink fieldCode="AR" term="%22Atik%2C+A%2E+Fatih%22">Atik, A. Fatih</searchLink><br /><searchLink fieldCode="AR" term="%22Bayri%2C+Yaşar%22">Bayri, Yaşar</searchLink><br /><searchLink fieldCode="AR" term="%22Bai%2C+Hanwen%22">Bai, Hanwen</searchLink><br /><searchLink fieldCode="AR" term="%22Kolb%2C+Luis+E%2E%22">Kolb, Luis E.</searchLink><br /><searchLink fieldCode="AR" term="%22Hebert%2C+Ryan+M%2E%22">Hebert, Ryan M.</searchLink><br /><searchLink fieldCode="AR" term="%22Omay%2C+S%2E+Bulent%22">Omay, S. Bulent</searchLink><br /><searchLink fieldCode="AR" term="%22Yilmaz%2C+Saliha%22">Yilmaz, Saliha</searchLink><br /><searchLink fieldCode="AR" term="%22Mishra-Gorur%2C+Ketu%22">Mishra-Gorur, Ketu</searchLink><br /><searchLink fieldCode="AR" term="%22Choi%2C+Murim%22">Choi, Murim</searchLink><br /><searchLink fieldCode="AR" term="%22Overton%2C+John+D%2E%22">Overton, John D.</searchLink><br /><searchLink fieldCode="AR" term="%22Jun+Yin%22">Jun Yin</searchLink><br /><searchLink fieldCode="AR" term="%22Holland%2C+Eric+C%2E%22">Holland, Eric C.</searchLink><br /><searchLink fieldCode="AR" term="%22Mane%2C+Shrikant%22">Mane, Shrikant</searchLink><br /><searchLink fieldCode="AR" term="%22State%2C+Matthew+W%2E%22">State, Matthew W.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 3/1/2013, Vol. 339 Issue 6123, p1077-1080. 4p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Meningioma%22">Meningioma</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+mutation%22">Genetic mutation</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+tumors%22">Brain tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Transcription+factors%22">Transcription factors</searchLink><br /><searchLink fieldCode="DE" term="%22Genomics%22">Genomics</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+research%22">Genetic research</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+therapy%22">Gene therapy</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The article discusses a report of a genomic analysis of 300 meningiomas, the most common form of primary brain tumors, with information on the discovery of genetic mutations in the proapoptotic E3 ubiquitin ligase TRAF7. Topics include the rate of prevalence for mutations in TRAF7; concurrent mutations in the KLF4 transcription factor which plays a part in inducing pluripotency; and the rate of mutation in the AKT1 and the SMO genes in non-NF2 mutant meningiomas. A comparison of non-NF2 and mutant NF2 meningiomas is presented, with information on targeted therapeutics for meningioma subtypes. |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=86140770 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1126/science.1233009 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 4 StartPage: 1077 Subjects: – SubjectFull: Meningioma Type: general – SubjectFull: Genetic mutation Type: general – SubjectFull: Brain tumors Type: general – SubjectFull: Transcription factors Type: general – SubjectFull: Genomics Type: general – SubjectFull: Genetic research Type: general – SubjectFull: Gene therapy Type: general Titles: – TitleFull: Genomic Analysis of Non-NF2 Meningiomas Reveals Mutations in TRAF7, KLF4, AKT1, and SMO. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Clark, Victoria E. – PersonEntity: Name: NameFull: Erson-Omay, E. Zeynep – PersonEntity: Name: NameFull: Caglayan, Ahmet Okay – PersonEntity: Name: NameFull: Sencar, Leman – PersonEntity: Name: NameFull: Serin, Akdes – PersonEntity: Name: NameFull: Ceyhun, Emre – PersonEntity: Name: NameFull: Atik, A. Fatih – PersonEntity: Name: NameFull: Bayri, Yaşar – PersonEntity: Name: NameFull: Bai, Hanwen – PersonEntity: Name: NameFull: Kolb, Luis E. – PersonEntity: Name: NameFull: Hebert, Ryan M. – PersonEntity: Name: NameFull: Omay, S. Bulent – PersonEntity: Name: NameFull: Yilmaz, Saliha – PersonEntity: Name: NameFull: Mishra-Gorur, Ketu – PersonEntity: Name: NameFull: Choi, Murim – PersonEntity: Name: NameFull: Overton, John D. – PersonEntity: Name: NameFull: Jun Yin – PersonEntity: Name: NameFull: Holland, Eric C. – PersonEntity: Name: NameFull: Mane, Shrikant – PersonEntity: Name: NameFull: State, Matthew W. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: 3/1/2013 Type: published Y: 2013 Identifiers: – Type: issn-print Value: 00368075 Numbering: – Type: volume Value: 339 – Type: issue Value: 6123 Titles: – TitleFull: Science (pre-March 2025) Type: main |
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