Bibliographic Details
| Title: |
Multiple Instances of Ancient Balancing Selection Shared Between Humans and Chimpanzees. |
| Authors: |
Leffler, Ellen M., Gao, Ziyue, Pfeifer, Susanne, Ségurel, Laure, Auton, Adam, Venn, Oliver, Bowden, Rory, Bontrop, Ronald, Wall, Jeffrey D., Sella, Guy, Donnelly3,5, Peter, McVean, Gilean, Przeworski, Molly |
| Source: |
Science (pre-March 2025). 3/29/2013, Vol. 339 Issue 6127, p1578-1582. 5p. |
| Subjects: |
Natural selection, Comparative genomics, Human genetic variation, Single nucleotide polymorphisms, Chimpanzees, Major histocompatibility complex genetics, Haplotypes, Glycoprotein genetics, Somatomedin genetics, Host-parasite relationship genetics, Primate adaptation |
| Abstract: |
The article describes a study in which a genome scan was used to investigate evidence of balancing natural selection in the single nucleotide polymorphisms (SNPs) shared by humans and chimpanzees. Researchers looked at shared SNP combinations in the major histocompatibility complex (MHC), as well as other gene regions with shared haplotypes. Several shared ancestral balancing polymorphisms were identified, including genes implicated in the expression of glycoproteins, the metabolism of methionine and folate, and expression of insulin-like growth factors. It is suggested that balancing selection in human genetic variation is linked to adaptation to host-pathogen dynamics. |
| Database: |
Psychology and Behavioral Sciences Collection |
