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Multiple Instances of Ancient Balancing Selection Shared Between Humans and Chimpanzees.

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Title: Multiple Instances of Ancient Balancing Selection Shared Between Humans and Chimpanzees.
Authors: Leffler, Ellen M., Gao, Ziyue, Pfeifer, Susanne, Ségurel, Laure, Auton, Adam, Venn, Oliver, Bowden, Rory, Bontrop, Ronald, Wall, Jeffrey D., Sella, Guy, Donnelly3,5, Peter, McVean, Gilean, Przeworski, Molly
Source: Science (pre-March 2025). 3/29/2013, Vol. 339 Issue 6127, p1578-1582. 5p.
Subjects: Natural selection, Comparative genomics, Human genetic variation, Single nucleotide polymorphisms, Chimpanzees, Major histocompatibility complex genetics, Haplotypes, Glycoprotein genetics, Somatomedin genetics, Host-parasite relationship genetics, Primate adaptation
Abstract: The article describes a study in which a genome scan was used to investigate evidence of balancing natural selection in the single nucleotide polymorphisms (SNPs) shared by humans and chimpanzees. Researchers looked at shared SNP combinations in the major histocompatibility complex (MHC), as well as other gene regions with shared haplotypes. Several shared ancestral balancing polymorphisms were identified, including genes implicated in the expression of glycoproteins, the metabolism of methionine and folate, and expression of insulin-like growth factors. It is suggested that balancing selection in human genetic variation is linked to adaptation to host-pathogen dynamics.
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
An: 86707994
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Multiple Instances of Ancient Balancing Selection Shared Between Humans and Chimpanzees.
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  Data: <searchLink fieldCode="AR" term="%22Leffler%2C+Ellen+M%2E%22">Leffler, Ellen M.</searchLink><br /><searchLink fieldCode="AR" term="%22Gao%2C+Ziyue%22">Gao, Ziyue</searchLink><br /><searchLink fieldCode="AR" term="%22Pfeifer%2C+Susanne%22">Pfeifer, Susanne</searchLink><br /><searchLink fieldCode="AR" term="%22Ségurel%2C+Laure%22">Ségurel, Laure</searchLink><br /><searchLink fieldCode="AR" term="%22Auton%2C+Adam%22">Auton, Adam</searchLink><br /><searchLink fieldCode="AR" term="%22Venn%2C+Oliver%22">Venn, Oliver</searchLink><br /><searchLink fieldCode="AR" term="%22Bowden%2C+Rory%22">Bowden, Rory</searchLink><br /><searchLink fieldCode="AR" term="%22Bontrop%2C+Ronald%22">Bontrop, Ronald</searchLink><br /><searchLink fieldCode="AR" term="%22Wall%2C+Jeffrey+D%2E%22">Wall, Jeffrey D.</searchLink><br /><searchLink fieldCode="AR" term="%22Sella%2C+Guy%22">Sella, Guy</searchLink><br /><searchLink fieldCode="AR" term="%22Donnelly3%2C5%2C+Peter%22">Donnelly3,5, Peter</searchLink><br /><searchLink fieldCode="AR" term="%22McVean%2C+Gilean%22">McVean, Gilean</searchLink><br /><searchLink fieldCode="AR" term="%22Przeworski%2C+Molly%22">Przeworski, Molly</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 3/29/2013, Vol. 339 Issue 6127, p1578-1582. 5p.
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  Data: <searchLink fieldCode="DE" term="%22Natural+selection%22">Natural selection</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+genomics%22">Comparative genomics</searchLink><br /><searchLink fieldCode="DE" term="%22Human+genetic+variation%22">Human genetic variation</searchLink><br /><searchLink fieldCode="DE" term="%22Single+nucleotide+polymorphisms%22">Single nucleotide polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Chimpanzees%22">Chimpanzees</searchLink><br /><searchLink fieldCode="DE" term="%22Major+histocompatibility+complex+genetics%22">Major histocompatibility complex genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Haplotypes%22">Haplotypes</searchLink><br /><searchLink fieldCode="DE" term="%22Glycoprotein+genetics%22">Glycoprotein genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Somatomedin+genetics%22">Somatomedin genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Host-parasite+relationship+genetics%22">Host-parasite relationship genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Primate+adaptation%22">Primate adaptation</searchLink>
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  Label: Abstract
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  Data: The article describes a study in which a genome scan was used to investigate evidence of balancing natural selection in the single nucleotide polymorphisms (SNPs) shared by humans and chimpanzees. Researchers looked at shared SNP combinations in the major histocompatibility complex (MHC), as well as other gene regions with shared haplotypes. Several shared ancestral balancing polymorphisms were identified, including genes implicated in the expression of glycoproteins, the metabolism of methionine and folate, and expression of insulin-like growth factors. It is suggested that balancing selection in human genetic variation is linked to adaptation to host-pathogen dynamics.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=86707994
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        Value: 10.1126/science.1234070
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      – Code: eng
        Text: English
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        PageCount: 5
        StartPage: 1578
    Subjects:
      – SubjectFull: Natural selection
        Type: general
      – SubjectFull: Comparative genomics
        Type: general
      – SubjectFull: Human genetic variation
        Type: general
      – SubjectFull: Single nucleotide polymorphisms
        Type: general
      – SubjectFull: Chimpanzees
        Type: general
      – SubjectFull: Major histocompatibility complex genetics
        Type: general
      – SubjectFull: Haplotypes
        Type: general
      – SubjectFull: Glycoprotein genetics
        Type: general
      – SubjectFull: Somatomedin genetics
        Type: general
      – SubjectFull: Host-parasite relationship genetics
        Type: general
      – SubjectFull: Primate adaptation
        Type: general
    Titles:
      – TitleFull: Multiple Instances of Ancient Balancing Selection Shared Between Humans and Chimpanzees.
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              Text: 3/29/2013
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