View in EDS HTML Full Text PDF Full Text

Should early improvement be re-defined to better predict the maintenance of response in first-episode schizophrenia patients?

Saved in:
Bibliographic Details
Title: Should early improvement be re-defined to better predict the maintenance of response in first-episode schizophrenia patients?
Authors: Schennach, R., Riesbeck, M., Mayr, A., Seemüller, F., Maier, W., Klingberg, S., Heuser, I., Klosterkötter, J., Gastpar, M., Schmitt, A., Sauer, H., Schneider, F., Jäger, M., Wölwer, W., Gaebel, W., Möller, H.‐J., Riedel, M.
Source: Acta Psychiatrica Scandinavica. Jun2013, Vol. 127 Issue 6, p474-481. 8p. 2 Charts, 3 Graphs.
Subjects: Schizophrenia, People with schizophrenia, Predictive validity, Receiver operating characteristic curves, Sensitivity & specificity (Statistics), Early medical intervention, Pathological psychology, Therapeutics
Abstract: Schennach R, Riesbeck M, Mayr A, Seemüller F, Maier W, Klingberg S, Heuser I, Klosterkötter J, Gastpar M, Schmitt A, Sauer H, Schneider F, Jäger M, Wölwer W, Gaebel W, Möller H-J, Riedel M. Should early improvement be re-defined to better predict the maintenance of response in first-episode schizophrenia patients? Objective: To evaluate the predictive validity of early response in first-episode schizophrenia within a 1-year follow-up trial and to compare the resulting cutoff to the currently proposed early response definition (20% improvement by week 2). Method: Receiver operator characteristic (ROC) analyses were used to identify the predictive validity of the psychopathological improvement of treatment from week 1 to week 8, regarding the maintenance of response until week 52 as well as to define the most reasonable cutoff in 132 first-episode patients. The Youden Index (maximum of sensitivity and specificity) was used to compare the newly developed and the commonly used early response definition. Results: Starting with week 6, a reasonable validity to predict the maintenance of response was found (area under the curve = 0.721) with the best fitting cutoff being a 51.6% PANSS total score improvement. Using this cutoff 74 patients (56%) were correctly identified to become responder and maintain response during follow-up (sensitivity: 0.747). The Youden Index was higher applying the newly developed early response cutoff featuring higher specificity compared to the commonly used early response definition. Conclusion: Regarding long-term treatment, it seems more appropriate to base predictions of the patient's maintenance of response not before 6 weeks of treatment. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 87549302
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Should early improvement be re-defined to better predict the maintenance of response in first-episode schizophrenia patients?
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Schennach%2C+R%2E%22">Schennach, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Riesbeck%2C+M%2E%22">Riesbeck, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Mayr%2C+A%2E%22">Mayr, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Seemüller%2C+F%2E%22">Seemüller, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Maier%2C+W%2E%22">Maier, W.</searchLink><br /><searchLink fieldCode="AR" term="%22Klingberg%2C+S%2E%22">Klingberg, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Heuser%2C+I%2E%22">Heuser, I.</searchLink><br /><searchLink fieldCode="AR" term="%22Klosterkötter%2C+J%2E%22">Klosterkötter, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Gastpar%2C+M%2E%22">Gastpar, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Schmitt%2C+A%2E%22">Schmitt, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Sauer%2C+H%2E%22">Sauer, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Schneider%2C+F%2E%22">Schneider, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Jäger%2C+M%2E%22">Jäger, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Wölwer%2C+W%2E%22">Wölwer, W.</searchLink><br /><searchLink fieldCode="AR" term="%22Gaebel%2C+W%2E%22">Gaebel, W.</searchLink><br /><searchLink fieldCode="AR" term="%22Möller%2C+H%2E‐J%2E%22">Möller, H.‐J.</searchLink><br /><searchLink fieldCode="AR" term="%22Riedel%2C+M%2E%22">Riedel, M.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. Jun2013, Vol. 127 Issue 6, p474-481. 8p. 2 Charts, 3 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22People+with+schizophrenia%22">People with schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Predictive+validity%22">Predictive validity</searchLink><br /><searchLink fieldCode="DE" term="%22Receiver+operating+characteristic+curves%22">Receiver operating characteristic curves</searchLink><br /><searchLink fieldCode="DE" term="%22Sensitivity+%26+specificity+%28Statistics%29%22">Sensitivity & specificity (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Early+medical+intervention%22">Early medical intervention</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+psychology%22">Pathological psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Schennach R, Riesbeck M, Mayr A, Seemüller F, Maier W, Klingberg S, Heuser I, Klosterkötter J, Gastpar M, Schmitt A, Sauer H, Schneider F, Jäger M, Wölwer W, Gaebel W, Möller H-J, Riedel M. Should early improvement be re-defined to better predict the maintenance of response in first-episode schizophrenia patients? Objective: To evaluate the predictive validity of early response in first-episode schizophrenia within a 1-year follow-up trial and to compare the resulting cutoff to the currently proposed early response definition (20% improvement by week 2). Method: Receiver operator characteristic (ROC) analyses were used to identify the predictive validity of the psychopathological improvement of treatment from week 1 to week 8, regarding the maintenance of response until week 52 as well as to define the most reasonable cutoff in 132 first-episode patients. The Youden Index (maximum of sensitivity and specificity) was used to compare the newly developed and the commonly used early response definition. Results: Starting with week 6, a reasonable validity to predict the maintenance of response was found (area under the curve = 0.721) with the best fitting cutoff being a 51.6% PANSS total score improvement. Using this cutoff 74 patients (56%) were correctly identified to become responder and maintain response during follow-up (sensitivity: 0.747). The Youden Index was higher applying the newly developed early response cutoff featuring higher specificity compared to the commonly used early response definition. Conclusion: Regarding long-term treatment, it seems more appropriate to base predictions of the patient's maintenance of response not before 6 weeks of treatment. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=87549302
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/acps.12006
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 474
    Subjects:
      – SubjectFull: Schizophrenia
        Type: general
      – SubjectFull: People with schizophrenia
        Type: general
      – SubjectFull: Predictive validity
        Type: general
      – SubjectFull: Receiver operating characteristic curves
        Type: general
      – SubjectFull: Sensitivity & specificity (Statistics)
        Type: general
      – SubjectFull: Early medical intervention
        Type: general
      – SubjectFull: Pathological psychology
        Type: general
      – SubjectFull: Therapeutics
        Type: general
    Titles:
      – TitleFull: Should early improvement be re-defined to better predict the maintenance of response in first-episode schizophrenia patients?
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Schennach, R.
      – PersonEntity:
          Name:
            NameFull: Riesbeck, M.
      – PersonEntity:
          Name:
            NameFull: Mayr, A.
      – PersonEntity:
          Name:
            NameFull: Seemüller, F.
      – PersonEntity:
          Name:
            NameFull: Maier, W.
      – PersonEntity:
          Name:
            NameFull: Klingberg, S.
      – PersonEntity:
          Name:
            NameFull: Heuser, I.
      – PersonEntity:
          Name:
            NameFull: Klosterkötter, J.
      – PersonEntity:
          Name:
            NameFull: Gastpar, M.
      – PersonEntity:
          Name:
            NameFull: Schmitt, A.
      – PersonEntity:
          Name:
            NameFull: Sauer, H.
      – PersonEntity:
          Name:
            NameFull: Schneider, F.
      – PersonEntity:
          Name:
            NameFull: Jäger, M.
      – PersonEntity:
          Name:
            NameFull: Wölwer, W.
      – PersonEntity:
          Name:
            NameFull: Gaebel, W.
      – PersonEntity:
          Name:
            NameFull: Möller, H.‐J.
      – PersonEntity:
          Name:
            NameFull: Riedel, M.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2013
              Type: published
              Y: 2013
          Identifiers:
            – Type: issn-print
              Value: 0001690X
          Numbering:
            – Type: volume
              Value: 127
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Acta Psychiatrica Scandinavica
              Type: main
ResultId 1