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Prenatal ontogeny of the dopamine-dependent neurobehavioral phenotype in Pitx3-deficient mice.

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Title: Prenatal ontogeny of the dopamine-dependent neurobehavioral phenotype in Pitx3-deficient mice.
Authors: Kleven, Gale A., Joshi, Priyanka, Voogd, Marco, Ronca, April E.
Source: European Journal of Neuroscience. May2013, Vol. 37 Issue 10, p1564-1572. 9p. 2 Charts, 4 Graphs.
Subjects: Ontogeny, Fetal behavior, Parkinson's disease, Dopaminergic neurons, Neurological disorders, Animal models in research, Laboratory mice, Dopamine
Abstract: Mouse models with prenatal alterations in dopaminergic functioning can provide new opportunities to identify fetal behavioral abnormalities and the underlying neural substrates dependent on dopamine. In this study, we tested the hypothesis that prenatal loss of nigrostriatal function is associated with fetal akinesia, or difficulty initiating movement. Specific behaviors were analysed in fetal offspring derived from pregnant Pitx3ak/2J and C57BL/6J dams on the last 4 days before birth (E15-18 of a 19-day gestation). Using digital videography, we analysed: (i) behavioral state, by quantification of high- and low-amplitude movements, (ii) interlimb movement synchrony, a measure of the temporal relationship between spontaneous movements of limb pairs, (iii) facial wiping, a characteristic response to perioral tactile stimulation similar to the defensive response in human infants, and (iv) oral grasp of a non-nutritive nipple, a component of suckling in the human infant. Pitx3 mutants showed a selective decrease in interlimb movement synchrony rates at the shortest (0.1 s) temporal interval coupled with significantly increased latencies to exhibit facial wiping and oral grasp. Collectively, our findings provide evidence that the primary fetal neurobehavioral deficit of the Pitx3 mutation is akinesia related to nigrostriatal damage. Other findings of particular interest were the differences in neurobehavioral functioning between C57BL/6J and Pitx3 heterozygous subjects, suggesting the two groups are not equivalent controls. These results further suggest that fetal neurobehavioral assessments are sensitive indicators of emerging neural dysfunction, and may have utility for prenatal diagnosis. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: Prenatal ontogeny of the dopamine-dependent neurobehavioral phenotype in Pitx3-deficient mice.
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  Data: <searchLink fieldCode="AR" term="%22Kleven%2C+Gale+A%2E%22">Kleven, Gale A.</searchLink><br /><searchLink fieldCode="AR" term="%22Joshi%2C+Priyanka%22">Joshi, Priyanka</searchLink><br /><searchLink fieldCode="AR" term="%22Voogd%2C+Marco%22">Voogd, Marco</searchLink><br /><searchLink fieldCode="AR" term="%22Ronca%2C+April+E%2E%22">Ronca, April E.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. May2013, Vol. 37 Issue 10, p1564-1572. 9p. 2 Charts, 4 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Ontogeny%22">Ontogeny</searchLink><br /><searchLink fieldCode="DE" term="%22Fetal+behavior%22">Fetal behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Dopaminergic+neurons%22">Dopaminergic neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Neurological+disorders%22">Neurological disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+models+in+research%22">Animal models in research</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+mice%22">Laboratory mice</searchLink><br /><searchLink fieldCode="DE" term="%22Dopamine%22">Dopamine</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Mouse models with prenatal alterations in dopaminergic functioning can provide new opportunities to identify fetal behavioral abnormalities and the underlying neural substrates dependent on dopamine. In this study, we tested the hypothesis that prenatal loss of nigrostriatal function is associated with fetal akinesia, or difficulty initiating movement. Specific behaviors were analysed in fetal offspring derived from pregnant Pitx3ak/2J and C57BL/6J dams on the last 4 days before birth (E15-18 of a 19-day gestation). Using digital videography, we analysed: (i) behavioral state, by quantification of high- and low-amplitude movements, (ii) interlimb movement synchrony, a measure of the temporal relationship between spontaneous movements of limb pairs, (iii) facial wiping, a characteristic response to perioral tactile stimulation similar to the defensive response in human infants, and (iv) oral grasp of a non-nutritive nipple, a component of suckling in the human infant. Pitx3 mutants showed a selective decrease in interlimb movement synchrony rates at the shortest (0.1 s) temporal interval coupled with significantly increased latencies to exhibit facial wiping and oral grasp. Collectively, our findings provide evidence that the primary fetal neurobehavioral deficit of the Pitx3 mutation is akinesia related to nigrostriatal damage. Other findings of particular interest were the differences in neurobehavioral functioning between C57BL/6J and Pitx3 heterozygous subjects, suggesting the two groups are not equivalent controls. These results further suggest that fetal neurobehavioral assessments are sensitive indicators of emerging neural dysfunction, and may have utility for prenatal diagnosis. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/ejn.12184
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        Text: English
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      – SubjectFull: Ontogeny
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      – SubjectFull: Fetal behavior
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      – SubjectFull: Parkinson's disease
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      – SubjectFull: Dopaminergic neurons
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      – SubjectFull: Animal models in research
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      – SubjectFull: Laboratory mice
        Type: general
      – SubjectFull: Dopamine
        Type: general
    Titles:
      – TitleFull: Prenatal ontogeny of the dopamine-dependent neurobehavioral phenotype in Pitx3-deficient mice.
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            NameFull: Kleven, Gale A.
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            NameFull: Ronca, April E.
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              M: 05
              Text: May2013
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